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PACS-1 and adaptor protein-1 mediate ACTH trafficking to the regulated secretory pathway.

Abstract：

:The regulated secretory pathway is a specialized form of protein secretion found in endocrine and neuroendocrine cell types. Pro-opiomelanocortin (POMC) is a pro-hormone that utilizes this pathway to be trafficked to dense core secretory granules (DCSGs). Within this organelle, POMC is processed to multiple bioactive hormones that play key roles in cellular physiology. However, the complete set of cellular membrane trafficking proteins that mediate the correct sorting of POMC to DCSGs remain unknown. Here, we report the roles of the phosphofurin acidic cluster sorting protein - 1 (PACS-1) and the clathrin adaptor protein 1 (AP-1) in the targeting of POMC to DCSGs. Upon knockdown of PACS-1 and AP-1, POMC is readily secreted into the extracellular milieu and fails to be targeted to DCSGs.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Dirk BS,End C,Pawlak EN,Van Nynatten LR,Jacob RA,Heit B,Dikeakos JD

doi

10.1016/j.bbrc.2018.11.085

subject

Has Abstract

pub_date

2018-12-09 00:00:00

pages

519-525

issue

1-4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(18)32509-9

journal_volume

507

pub_type

杂志文章

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