In vivo delivery of small interfering RNA targeting brain capillary endothelial cells.

abstract：:Breath isoprene accounts for most of the hydrocarbon removal via exhalation and is thought to serve as a non-invasive indicator for assaying several metabolic effects in the human body. The primary objective of this paper is to introduce a novel working hypothesis with respect to the endogenous source of this compound...

journal_title：Biochemical and biophysical research communications

authors： King J,Mochalski P,Unterkofler K,Teschl G,Klieber M,Stein M,Amann A,Baumann M

更新日期：2012-07-06 00:00:00

abstract：:Regeneration and functional reconstruction of peripheral nerve defects remained a significant clinical challenge. Nerve guide conduits, with seed cells or neurotrophic factors (NTFs), had been widely used to improve the repair and regeneration of injured peripheral nerve. Pyrroloquinoline quinone (PQQ) was an antioxid...

journal_title：Biochemical and biophysical research communications

authors： Luo L,Gan L,Liu Y,Tian W,Tong Z,Wang X,Huselstein C,Chen Y

更新日期：2015-02-20 00:00:00

abstract：:Autophosphorylation of CaM-kinase II produces a form of the enzyme not requiring Ca(2+)/calmodulin for sustained activity. We report that autophosphorylated CaM-kinase II dephosphorylates itself in the presence of ADP (termed autodephosphorylation). The dephosphorylation was unaffected by phosphatase inhibitors and wa...

journal_title：Biochemical and biophysical research communications

authors： Kim SA,Hudmon A,Volmer A,Waxham MN

更新日期：2001-04-06 00:00:00

abstract：:Rubredoxin and desulforedoxin both contain an Fe(S-Cys)4 center. However, the spectroscopic properties of the center in desulforedoxin differ from rubredoxin. These differences arise from a distortion of the metal site hypothesized to result from adjacent cysteine residues in the primary sequence of desulforedoxin. Tw...

journal_title：Biochemical and biophysical research communications

authors： Yu L,Kennedy M,Czaja C,Tavares P,Moura JJ,Moura I,Rusnak F

更新日期：1997-02-24 00:00:00

abstract：:Hepcidin is a main regulator of iron metabolism, of which abnormal expression affects intestinal absorption and reticuloendothelial sequestration of iron by interacting with ferroportin. It is also noted that abnormal iron accumulation is one of the key factors to facilitate promotion and progression of cancer includi...

journal_title：Biochemical and biophysical research communications

authors： Toki Y,Sasaki K,Tanaka H,Yamamoto M,Hatayama M,Ito S,Ikuta K,Shindo M,Hasebe T,Nakajima S,Sawada K,Fujiya M,Torimoto Y,Ohtake T,Kohgo Y

更新日期：2016-08-05 00:00:00

abstract：:Interleukin-1 alpha induced an increase in both the cellular accumulation of cis-diamminedichloroplatinum (II) (cisplatin) and DNA platination and significantly reduced the removal of platinum from DNA of human ovarian (NIH: OVCAR-3) carcinoma cells in culture. The combinations of IL-1 alpha and cisplatin were highly ...

journal_title：Biochemical and biophysical research communications

authors： Benchekroun MN,Parker R,Reed E,Sinha BK

更新日期：1993-08-31 00:00:00

abstract：:gamma S-Crystallin from shark eye lenses, formerly termed beta s crystallin in mammalian lenses, is structurally characterized in this study by cDNA cloning and sequencing. To facilitate sequence characterization of gamma S-crystallin possessing intermediate structural properties between beta- and gamma-crystallins, c...

journal_title：Biochemical and biophysical research communications

authors： Pan FM,Chuang MH,Chiou SH

更新日期：1997-11-07 00:00:00

abstract：:Upon centrifugation of gently lysed T. cruzi cells through a sucrose gradient, a free DNA fraction was shown to contain catenated dimers and knotted DNA structures. Southern hybridization and electron microscopic studies indicated that both of these structures derived from minicircle DNA, the major component of T. cru...

journal_title：Biochemical and biophysical research communications

authors： Valenzuela MS,Bardhan S,Krishnamani MR,Siddiqui KA

更新日期：1991-01-31 00:00:00

abstract：:The physiological importance of the intestinal plasma membrane calcium pump, isoform 1, (Pmca1, Atp2b1), in calcium absorption and homeostasis has not been previously demonstrated in vivo. Since global germ-line deletion of the Pmca1 in mice is associated with embryonic lethality, we selectively deleted the Pmca1 in i...

journal_title：Biochemical and biophysical research communications

authors： Ryan ZC,Craig TA,Filoteo AG,Westendorf JJ,Cartwright EJ,Neyses L,Strehler EE,Kumar R

更新日期：2015-11-06 00:00:00

abstract：:Hydrogen sulfide (H(2)S) is an important gasotransmitter that generated in mammalian cells from l-cysteine metabolism. Little is known about its protective role in oxidative stress. In the present study, we investigated whether H(2)S could affect homocysteine (HCY)-induced cytotoxicity and oxidative stress in vascular...

journal_title：Biochemical and biophysical research communications

authors： Yan SK,Chang T,Wang H,Wu L,Wang R,Meng QH

更新日期：2006-12-15 00:00:00

abstract：:Several studies have shown that transplantation of embryonic stem cells into diabetic animals either improved or normalized blood glucose levels. In this study, we examined the dose-dependent effect of early (prediabetic stage) intravenous administration of human umbilical cord blood (HUCB) mononuclear cells on blood ...

journal_title：Biochemical and biophysical research communications

authors： Ende N,Chen R,Reddi AS

更新日期：2004-12-17 00:00:00

abstract：:alpha-Crystallin, a major eye lens protein, has been shown to function like a molecular chaperone by suppressing the aggregation of other proteins induced by various stress conditions. Ultraviolet (UV) radiation is known to cause structural and functional alterations in the lens macromolecules. Earlier we observed tha...

journal_title：Biochemical and biophysical research communications

authors： Reddy GB,Reddy PY,Suryanarayana P

更新日期：2001-04-06 00:00:00

abstract：:Toll-like receptors (TLRs) are important initiators in innate immune responses against pathogenic microbes such as viruses, intracellular bacteria or parasites. Although the innate immune system is designed to fight infectious pathogens, excessive activation of TLR signaling may lead to unwarranted inflammation with h...

journal_title：Biochemical and biophysical research communications

authors： Liu J,Zhang Z,Chai L,Che Y,Min S,Yang R

更新日期：2013-04-26 00:00:00

abstract：:We have previously shown that C-CAM1 cell adhesion molecule can suppress the growth of prostate cancer cells in vivo. In this study, we determined the minimal domain of C-CAM1 that is required for its tumor-suppressive activity. DU145 prostate cancer cells were infected with recombinant adenoviruses containing various...

journal_title：Biochemical and biophysical research communications

authors： Estrera VT,Luo W,Phan D,Earley K,Hixson DC,Lin SH

更新日期：1999-10-05 00:00:00

abstract：:A tryptic peptide of bovine beta-casein (amino acid residues 184-202) was used as a model antigen to investigate how the relative position of the (helper) T cell and B cell determinants on a protein antigen influences the antibody response. Immunization with the peptide elicited a considerably higher anti-peptide resp...

journal_title：Biochemical and biophysical research communications

authors： Hachimura S,Enomoto A,Kaminogawa S

更新日期：1990-06-15 00:00:00

abstract：:Enterolactone, a lignan that has been identified in biological samples from man and several mammals, shares with ascorbic acid and cardiac glycosides a gamma-butyrolactone. It displaces 3H-ouabain from its binding sites on cardiac digitalis receptor and inhibits, dose dependently, the Na+, K+-ATPase activity of human ...

journal_title：Biochemical and biophysical research communications

authors： Fagoo M,Braquet P,Robin JP,Esanu A,Godfraind T

更新日期：1986-02-13 00:00:00

abstract：:A monoclonal antibody against Neurospora soluble adenylate cyclase was obtained. The antibody inhibits cyclase activities from several lower eucaryotic organisms but not activities associated to testicular cytosol or turkey erythrocyte membranes. ...

journal_title：Biochemical and biophysical research communications

authors： Molina y Vedia L,Torruella M,Attar R,Podesta E,Reig JA,Flawiá MM,Torres HN

更新日期：1983-06-29 00:00:00

abstract：:Global rise in obesity at early age due to overconsumption of energy-dense food is the major health problem which increases the exposure to obesity over longer duration. Recently we reported that the severity of ovarian dysfunction depends on the duration of obesity. In the present study, we examined the consequences ...

journal_title：Biochemical and biophysical research communications

authors： Kannan S,Bhaskaran RS

更新日期：2019-11-12 00:00:00

abstract：:Ubiquitinlation of proteins is prevalent and important in both normal and pathological cellular processes. Deubiquitinating enzymes (DUBs) can remove the ubiquitin tags on substrate proteins and dynamically regulate the ubiquitination process. The PPPDE family proteins were predicted to be a novel class of deubiquitin...

journal_title：Biochemical and biophysical research communications

authors： Xie X,Wang X,Jiang D,Wang J,Fei R,Cong X,Wei L,Wang Y,Chen H

更新日期：2017-06-24 00:00:00

abstract：:Lipocortin I-S100 (calcyclin) heterotetramer exhibited ATPase activity in the presence of dsDNA but not ssDNA. To demonstrate its helicase activity, an 80-mer polynucleotide complementary to the replication origin of M13mp18 was synthesized, and the oligonucleotide, (dC)(20), was ligated to either its 5'- or 3'- end f...

journal_title：Biochemical and biophysical research communications

authors： Hirata A,Hirata F

更新日期：2002-02-22 00:00:00

abstract：:The COP9 signalosome (CSN) is a regulator of the ubiquitin (Ub) proteasome system (UPS). In the UPS, proteins are Ub-labeled for degradation by Ub ligases conferring substrate specificity. The CSN controls a large family of Ub ligases called cullin-RING ligases (CRLs), which ubiquitinate cell cycle regulators, transcr...

journal_title：Biochemical and biophysical research communications

authors： Rockel B,Schmaler T,Huang X,Dubiel W

更新日期：2014-07-25 00:00:00

abstract：:We demonstrate that the 204 bp intronic gene fragment of C3(1), which has a specific in vitro affinity for the androgen receptor, is able to confer androgen responsiveness to a heterologous promoter. This characteristic is completely destroyed by a single G----T substitution, affecting a 5'-TGTTCT-3' element that clos...

journal_title：Biochemical and biophysical research communications

authors： Claessens F,Celis L,Peeters B,Heyns W,Verhoeven G,Rombauts W

更新日期：1989-10-31 00:00:00

abstract：:The present study revealed that low density lipoprotein (LDL) obtained from rabbits fed highly purified eicosapentaenoic acid-ethyl ester (EPA-E) (EPA-LDL) was significantly less susceptible to oxidative modification catalyzed by Cu2+ as compared to LDL from rabbits fed a normal diet (control LDL). In a comparison of ...

journal_title：Biochemical and biophysical research communications

authors： Saito H,Chang KJ,Tamura Y,Yoshida S

更新日期：1991-02-28 00:00:00

abstract：:After a peripheral nerve injury, the remaining Schwann cells undergo proliferation and adopt a migratory phenotype to prepare for the regeneration of nerves. Celsr2 has been reported to play an important role in the development and maintenance of the function of the nervous system. However, the role and mechanism of C...

journal_title：Biochemical and biophysical research communications

authors： Zhou X,Zhan Z,Tang C,Li J,Zheng X,Zhu S,Qi J

更新日期：2020-12-17 00:00:00

abstract：:The present study demonstrates that human platelets possess a specific L-arginine transport system able to provide adequate amounts of L-arginine for endogenous nitric oxide production. L-arginine uptake takes place through a saturable high affinity carrier-mediated Na(+)-independent process which is significantly inh...

journal_title：Biochemical and biophysical research communications

authors： Vasta V,Meacci E,Farnararo M,Bruni P

更新日期：1995-01-26 00:00:00

abstract：:Specific knock-down of cellular gene expression using short, interfering RNAs (siRNAs) has become a powerful tool for functional genomics studies and a promising future therapeutic approach. However, recent studies have revealed that siRNAs can trigger an innate immune response upon intravenous administration in mice ...

journal_title：Biochemical and biophysical research communications

authors： Yoo JW,Hong SW,Kim S,Lee DK

更新日期：2006-09-08 00:00:00

abstract：:The brown planthopper, Nilaparvata lugens (N. lugens, Hemiptera: Delphacidae), and the green rice leafhopper, Nephotettix cincticeps (N. cincticeps, Hemiptera: Cicadellidae), two sap-sucking feeders, have caused many destructive agricultural disasters in East Asia, as they can bring diseases like 'hopper burn' and tra...

journal_title：Biochemical and biophysical research communications

authors： Qian N,Zheng P,Wang Y,Pan S,Li Y,Zhang C,Chen J,Teng J

更新日期：2016-02-19 00:00:00

abstract：:Neurosteroids are endogenously derived compounds, mediating rapid effects in the central nervous system. They participate in vital processes, including memory and learning, neuroplasticity, and neuroprotection in Alzheimer's disease. However, the mechanisms behind those effects remain to be elucidated. The neurosteroi...

journal_title：Biochemical and biophysical research communications

authors： Elfverson M,Linde AM,Le Grevès P,Zhou Q,Nyberg F,Johansson T

更新日期：2008-07-25 00:00:00

abstract：:In T lymphocyte, activation of Kv1.3 channel, the major voltage-dependent K(+) channel, is an essential step for cell proliferation in immune responses. Here, effects of anti-CD3 and anti-CD28 antibodies on Kv1.3 current were examined in three types of human T lymphocyte derived cell lines, Jurkat E6-1, p56lck-kinase ...

journal_title：Biochemical and biophysical research communications

authors： Matsushita Y,Ohya S,Itoda H,Kimura T,Suzuki Y,Yamamura H,Imaizumi Y

更新日期：2008-09-12 00:00:00

abstract：:Single particle tracking (SPT) is a powerful technique for studying mRNA dynamics in cells. Although SPT of mRNA has been performed by labeling mRNA with fluorescent dyes or proteins, observation of mRNA for long durations with high temporal resolution has been difficult due to weak fluorescence and rapid photobleachi...

journal_title：Biochemical and biophysical research communications

authors： Ishihama Y,Funatsu T

更新日期：2009-03-27 00:00:00