Abstract:
:The present study demonstrates that human platelets possess a specific L-arginine transport system able to provide adequate amounts of L-arginine for endogenous nitric oxide production. L-arginine uptake takes place through a saturable high affinity carrier-mediated Na(+)-independent process which is significantly inhibited by L-ornithine, L-lysine and N omega-methyl-L-arginine. The high affinity of the transport process and the pattern of inhibition are consistent with mediation of L-arginine transport via the Na(+)-independent y+ system. The data on the kinetic parameters of the transporter suggest a possible role for arginine plasma levels in the regulation of platelet nitric oxide production.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Vasta V,Meacci E,Farnararo M,Bruni Pdoi
10.1006/bbrc.1995.1125subject
Has Abstractpub_date
1995-01-26 00:00:00pages
878-84issue
3eissn
0006-291Xissn
1090-2104pii
S0006-291X(85)71125-4journal_volume
206pub_type
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