Identification of a specific transport system for L-arginine in human platelets.

Abstract:

:The present study demonstrates that human platelets possess a specific L-arginine transport system able to provide adequate amounts of L-arginine for endogenous nitric oxide production. L-arginine uptake takes place through a saturable high affinity carrier-mediated Na(+)-independent process which is significantly inhibited by L-ornithine, L-lysine and N omega-methyl-L-arginine. The high affinity of the transport process and the pattern of inhibition are consistent with mediation of L-arginine transport via the Na(+)-independent y+ system. The data on the kinetic parameters of the transporter suggest a possible role for arginine plasma levels in the regulation of platelet nitric oxide production.

authors

Vasta V,Meacci E,Farnararo M,Bruni P

doi

10.1006/bbrc.1995.1125

subject

Has Abstract

pub_date

1995-01-26 00:00:00

pages

878-84

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(85)71125-4

journal_volume

206

pub_type

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