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Ingestion of eicosapentaenoic acid-ethyl ester renders rabbit LDL less susceptible to Cu2(+)-catalyzed-oxidative modification.

Abstract：

:The present study revealed that low density lipoprotein (LDL) obtained from rabbits fed highly purified eicosapentaenoic acid-ethyl ester (EPA-E) (EPA-LDL) was significantly less susceptible to oxidative modification catalyzed by Cu2+ as compared to LDL from rabbits fed a normal diet (control LDL). In a comparison of fatty acid composition of LDL, the contents of EPA and docosapentaenoic acid were significantly increased in EPA-LDL as compared to control LDL. The content of arachidonic acid (AA) was the same in both LDL groups. The contents of total cholesterol, free cholesterol, triglyceride, and phospholipid in LDL were unchanged by EPA-E ingestion. These data raise the possibility that EPA may protect LDL from oxidative modification, leading to a reduction of oxidized LDL in atherosclerotic lesions, and that this may be how EPA exert its anti-atherosclerotic action.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Saito H,Chang KJ,Tamura Y,Yoshida S

doi

10.1016/s0006-291x(05)81200-8

subject

Has Abstract

pub_date

1991-02-28 00:00:00

pages

61-7

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)81200-8

journal_volume

175

pub_type

杂志文章

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