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A distinct form of tau is selectively incorporated into Alzheimer's paired helical filaments.

Abstract：

:Tau, a microtubule-associated phosphoprotein, was identified as a definite component of paired helical filaments which progressively accumulate in Alzheimer's disease brain. To learn more about tau in the aged brain, we have isolated and sequenced a cDNA clone encoding tau from a cDNA library of an aged human brain. The cloned cDNA sequence included a new insert of 93 nucleotides, which added a fourth repeat to the three-repeat type of tau already reported. Perhaps, this four-repeat type of tau is predominant in normal aged brain. In contrast, the sequence analysis of paired helical filaments showed that the integrated tau is of three-repeat type. This indicates that a distinct form of tau is selectively incorporated into paired helical filaments.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Mori H,Hamada Y,Kawaguchi M,Honda T,Kondo J,Ihara Y

doi

10.1016/0006-291x(89)92240-7

subject

Has Abstract

pub_date

1989-03-31 00:00:00

pages

1221-6

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(89)92240-7

journal_volume

159

pub_type

杂志文章

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