Abstract：
:The diagnostic significance of phosphoglycerate mutase (PGM) B-type isozyme activity capable of being inducible under hypoxia at the gene level as a serum marker for cerebral stroke was investigated. The normal level (mean +/- 2 SD) in human serum was determined to be 38 +/- 18 units/L. Within 2 h after the onset of cerebral stroke (n = 65), B-type isozyme activity was elevated to 68 +/- 36 units/L, and retained to be higher level until 1-3 days. Serum B-type isozyme activities of 52 survival cases and 13 dead cases, being judged at the period of 1-2 months after the onset, were retrospectively compared; B-type isozyme activity that had been measured within 24 h after the onset was significantly higher (81 +/- 42 units/L) for the dead cases than for survival cases (57 +/- 27 units/L) with P < 0.05. These results suggest that serum PGM B-type isozyme has the potential as a novel marker for diagnosis of cerebral stroke and its severity.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Hayashi T,Matuo Ydoi
10.1006/bbrc.2001.5666subject
Has Abstractpub_date
2001-10-05 00:00:00pages
843-5issue
4eissn
0006-291Xissn
1090-2104pii
S0006-291X(01)95666-9journal_volume
287pub_type
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