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Platelet aggregation. I. Regulation by cyclic AMP and prostaglandin E1.

Abstract：

:Platelet aggregation plays a major role in thrombogenesis. This study was undertaken to examine the inhibition of platelet aggregation induced by adenosine diphosphate. It is known that cyclic AMP (adenosine monophosphate) and its dibutyryl derivative inhibit platelet aggregation. This study showed that prostaglandin E1 (PGE1) also inhibits platelet aggregation and stimulates cyclic AMP synthesis by stimulation of adenyl cyclose. Caffeine, on the other hand, inhibits platelet phosphodiesterase, and increases cyclic AMP levels. PGA1 and PGF1 alpha can also inhibit platelet aggregation but only at very high concentrations.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Marquis NR,Vigdahl RL,Tavormina PA

doi

10.1016/0006-291x(69)90298-8

subject

Has Abstract

pub_date

1969-09-10 00:00:00

pages

965-72

issue

6

eissn

0006-291X

issn

1090-2104

pii

0006-291X(69)90298-8

journal_volume

36

pub_type

杂志文章

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