Immediate and neurotoxic effects of HIV protein gp120 act through CXCR4 receptor.

abstract：:The cytosolic protein synaphin/complexin critically regulates fast neurotransmitter release at the synapse by binding to SNARE complex. However, the exact mechanism of its action remains unclear, and very little is known about how it is physiologically regulated. Here we show that synaphins (Syps) 1 and 2 can be phosp...

journal_title：Biochemical and biophysical research communications

authors： Shata A,Saisu H,Odani S,Abe T

更新日期：2007-03-16 00:00:00

abstract：:The bromodomain and extraterminal (BET) domain family proteins are epigenetic modulators involved in the reading of acetylated lysine residues. The first BET protein inhibitor to be identified, (+)-JQ1, a thienotriazolo-1, 4-diazapine, binds selectively to the acetyl lysine-binding pocket of BET proteins. We evaluated...

journal_title：Biochemical and biophysical research communications

authors： Goupille O,Penglong T,Kadri Z,Granger-Locatelli M,Fucharoen S,Maouche-Chrétien L,Prost S,Leboulch P,Chrétien S

更新日期：2016-04-15 00:00:00

abstract：:Sepsis-induced muscle proteolysis mainly reflects ubiquitin-proteasome-dependent protein degradation. The effect of in vivo administration of a proteasome inhibitor on muscle protein breakdown during sepsis is not known. We treated rats with the proteasome inhibitor N-benzyloxycarbonyl-Ile-Glu-(O-t-butyl)-Ala-leucinal...

journal_title：Biochemical and biophysical research communications

authors： Fischer D,Gang G,Pritts T,Hasselgren PO

更新日期：2000-04-02 00:00:00

abstract：:S-100 protein and annexin II2-p11(2) were reported to inhibit and to stimulate the assembly of glial fibrillary acidic protein (GFAP), respectively, in a Ca(2+)-dependent manner. Here we show by a number of experimental approaches that S-100 protein contrasts all the effects of annexin II2-p11(2) on GFAP assembly and,...

journal_title：Biochemical and biophysical research communications

authors： Bianchi R,Garbuglia M,Verzini M,Giambanco I,Spreca A,Donato R

更新日期：1995-03-28 00:00:00

abstract：:ADP-ribosylation by cholera toxin of the guanine nucleotide binding regulatory protein (Gs) of rat liver membrane adenylate cyclase was inhibited by 0.1-1 mM MDL 12330A or 0.1-1 mM chlorpromazine. Basal as well as cholera toxin activated adenylate cyclase activity in liver membranes was also inhibited by the two drugs...

journal_title：Biochemical and biophysical research communications

authors： Bitonti AJ

更新日期：1984-04-30 00:00:00

abstract：:Human telomerase reverse transcriptase (hTERT), a catalytic subunit of telomerase, is the primary determinant for telomerase enzyme activity, which has been associated with cellular immortality. Expression of the hTERT gene is regulated by various extracellular (external) stimuli and is aberrantly up-regulated in more...

journal_title：Biochemical and biophysical research communications

authors： Yoo YS,Park S,Gwak J,Ju BG,Oh S

更新日期：2015-09-11 00:00:00

abstract：:To correlate structural data on substrates of human fibroblast collagenase with their interaction with the enzyme, we have studied: Ac-PLG-s-LLG-O-ethyl ester (I), Dnp-PLGLWA(d-Arg)-NH2 (II), AcGPEGLRVG-O-ethyl ester (III) and Succ-GPLGP-O-amidomethylcoumaryl ester (IV). Peptides I and II represent collagenase cleavag...

journal_title：Biochemical and biophysical research communications

authors： Upadhye S,Ananthanarayanan VS

更新日期：1995-10-13 00:00:00

abstract：:The present study demonstrates that exposure of human thyroid slices to thyrotropin causes an increase in phospholipid metabolism as measured by an increased incorporation of myo-2-[3H]-inositol into phosphatidylinositol, the generation of InsP3 and formation of GInsP as well as metabolism of phosphatidylcholine and p...

journal_title：Biochemical and biophysical research communications

authors： Mosko P,Zarzycki W,Jaroszewicz L,Kinalska I

更新日期：1994-06-30 00:00:00

abstract：:The effect of vitamin A on the expression of apoAI and CIII genes in intact rats was studied. In vitamin A-deficient rats, the hepatic level of apoAI mRNA was increased and enhanced by an oral administration of excess retinoic acid(RA). A similar administration to normal rats caused an increase in the apoAI mRNA level...

journal_title：Biochemical and biophysical research communications

authors： Nagasaki A,Kikuchi T,Kurata K,Masushige S,Hasegawa T,Kato S

更新日期：1994-12-30 00:00:00

abstract：:On the basis of the well-known effect of ethanol poisoning on the prooxidant/antioxidant balance of human and rodent liver we tested the response of the mitochondrial manganese-containing superoxide dismutase (MnSOD) in the liver of rats following an acute ethanol load or chronically intoxicated with an alcohol-supple...

journal_title：Biochemical and biophysical research communications

authors： Koch OR,De Leo ME,Borrello S,Palombini G,Galeotti T

更新日期：1994-06-30 00:00:00

abstract：:Our previous data from a human leukemic cell line made resistant to the nucleoside analog (NA) 9-β-D-arabinofuranosylguanine (AraG) revealed a massive upregulation of fetal hemoglobin (HbF) genes and the ABCB1 gene coding for the multidrug resistance P-glycoprotein (P-gp). The expression of these genes is regulated th...

journal_title：Biochemical and biophysical research communications

authors： Fyrberg A,Skoglund K,Wolk M,Lotfi K

更新日期：2012-10-26 00:00:00

abstract：:Hepatocellular carcinoma (HCC) tumors evade death in part by downregulating expression of the tumor suppressor gene Interferon regulatory factor-1 (IRF-1). However, the molecular mechanisms accounting for IRF-1 suppression in HCC have not been well described. In this study, we identified a novel microRNA-301a (miR-301...

journal_title：Biochemical and biophysical research communications

authors： Dong K,Du Q,Cui X,Wan P,Kaltenmeier C,Luo J,Yan B,Yan Y,Geller DA

更新日期：2020-04-02 00:00:00

abstract：:Two forms of human placental alkaline phosphatase have been purified to homogeneity utilizing high performance liquid chromatography. Both have the same amino acid composition but they differ in their carbohydrate substituents. Sequence data indicate that the two forms are identical for the first forty two residues fr...

journal_title：Biochemical and biophysical research communications

authors： Ezra E,Blacher R,Udenfriend S

更新日期：1983-11-15 00:00:00

abstract：:Interleukin-6 (IL-6) is a multifunctional cytokine playing roles in the immune system, hematopoiesis, and acute phase reactions. IL-6 also regulates the growth of various types of human malignant tumors. Here we demonstrate that IL-6-induced gene expression was suppressed by a specific heat-shock protein 90 (Hsp90) in...

journal_title：Biochemical and biophysical research communications

authors： Sato N,Yamamoto T,Sekine Y,Yumioka T,Junicho A,Fuse H,Matsuda T

更新日期：2003-01-24 00:00:00

abstract：:Myostatin, a member of the Transforming Growth Factor beta (TGF-β) superfamily, plays an important role as a negative regulator of skeletal muscle growth and differentiation. We have previously reported that IGF-1 induces a transient myostatin mRNA expression, through the activation of the Nuclear Factor of Activated ...

journal_title：Biochemical and biophysical research communications

authors： Zuloaga R,Fuentes EN,Molina A,Valdés JA

更新日期：2013-10-18 00:00:00

abstract：:Enhancer sequences analysed using the informational spectrum method (ISM) show a characteristic frequency at .0488. It has been shown that the characteristic frequency for some DNA binding proteins overlaps the characteristic frequency of their target DNA sequences. We suggest here that two types of proteins, homeopro...

journal_title：Biochemical and biophysical research communications

authors： Cosić I,Nesić D,Pavlović M,Williams R

更新日期：1986-12-15 00:00:00

abstract：:Contractile properties differ between skeletal, cardiac and smooth muscles as well as between various skeletal muscle fiber types. This functional diversity is thought to be mainly related to different speeds of myosin head pulling cycles, with the molecular mechanism of force generation being essentially the same. In...

journal_title：Biochemical and biophysical research communications

authors： Galler S,Andruchov O,Stephenson GM,Stephenson DG

更新日期：2009-07-17 00:00:00

abstract：:Osteoclasts play a crucial role in osteolytic bone diseases, such as osteoporosis, rheumatoid arthritis, periodontitis, Paget's disease of bone and bone metastatic tumors. Therefore, controlling osteoclast differentiation and function has been considered a promising therapeutic strategy. Here, we show that necrostatin...

journal_title：Biochemical and biophysical research communications

authors： Fuji H,Ohmae S,Noma N,Takeiri M,Yasutomi H,Izumi K,Ito M,Toyomoto M,Iwaki S,Takemoto K,Seo S,Taura K,Hida S,Aoyama M,Ishihama Y,Hagiwara M,Takeda N,Hatano E,Iwaisako K,Uemoto S,Asagiri M

更新日期：2018-09-05 00:00:00

abstract：:Replication of human immunodeficiency virus type 1 (HIV-1) is regulated at reverse transcription. Cellular topoisomerase I has been reported to be carried into HIV-1 virions and enhance cDNA synthesis in vitro, suggesting that topoisomerase I expressed in virus producer cells regulates reverse transcription. Here, by ...

journal_title：Biochemical and biophysical research communications

authors： Takahashi H,Sawa H,Hasegawa H,Shoya Y,Sata T,Hall WW,Nagashima K,Kurata T

更新日期：2002-06-07 00:00:00

abstract：:Although chronic voluntary physical activity has been shown to enhance hippocampal brain-derived neurotrophic factor (BDNF) expression in animals, the effects of forced exercise on a treadmill have not been fully investigated. We assessed induction of c-fos and BDNF expression with acute exercise at different running ...

journal_title：Biochemical and biophysical research communications

authors： Soya H,Nakamura T,Deocaris CC,Kimpara A,Iimura M,Fujikawa T,Chang H,McEwen BS,Nishijima T

更新日期：2007-07-13 00:00:00

abstract：:The nonamer 5'd(CTCAGCCTC) 3' 1 has been reacted with cis-diamminediaquaplatinum(II) in water at pH 4.2. The major reaction product was shown by enzymatic digestion and 1H NMR to be the d(ApG)cis-Pt(NH3)2 chelate [cis-Pt(NH3)2[d(CTCAGCCTC)-N7(4),N7(5)]] 1-Pt. When mixed with its complementary strand 2, 1-Pt forms a B ...

journal_title：Biochemical and biophysical research communications

authors： Fouchet MH,Gauthier C,Guittet E,Girault JP,Igolen J,Chottard JC

更新日期：1992-01-31 00:00:00

abstract：:The spindle checkpoint is a surveillance mechanism that ensures the fidelity of chromosome segregation in mitosis. Here we show that fission yeast casein kinase II (CK2) is required for this checkpoint function. In the CK2 mutants mitosis occurs in the presence of a spindle defect, and the spindle checkpoint protein M...

journal_title：Biochemical and biophysical research communications

authors： Shimada M,Yamamoto A,Murakami-Tonami Y,Nakanishi M,Yoshida T,Aiba H,Murakami H

更新日期：2009-10-23 00:00:00

abstract：:We evaluated the use of a combination of adipose tissue derived adult stem cells (ADSCs) obtained from liposuction and injectable poly(lactic-co-glycolic acid) (PLGA) spheres for adipose tissue engineering. Adipogenesis was examined in nude mice injected subcutaneously with ADSCs (group I), PLGA spheres (group II), or...

journal_title：Biochemical and biophysical research communications

authors： Choi YS,Cha SM,Lee YY,Kwon SW,Park CJ,Kim M

更新日期：2006-06-30 00:00:00

abstract：:NADH-rubredoxin oxidoreductase (NROR), a flavoprotein from the obligately anaerobe Clostridium acetobutylicum is encoded by an ORF (nror) of 1140 nucleotides. Whereas primary structure analysis reveals that NROR has amino acid sequence patterns homologous with those involved in FAD and NAD-binding, the enzyme is dista...

journal_title：Biochemical and biophysical research communications

authors： Guedon E,Petitdemange H

更新日期：2001-07-13 00:00:00

abstract：:We aimed to assess the combined effect of trifluridine (FTD) and ionizing radiation (IR) on colorectal cancer cells in vitro. Colorectal cancer cells, HT-29, HCT-15, and HCT 116, showing low, medium, and high sensitivity to IR, respectively, were treated with the combinations of FTD and IR, and evaluated by the clonog...

journal_title：Biochemical and biophysical research communications

authors： Matsuoka K,Kobunai T,Nukatsuka M,Takechi T

更新日期：2017-12-09 00:00:00

abstract：:Enhancer of Zeste 2 (EZH2) is the key enzymatic factor in Polycomb Repressive Complex 2 (PRC2), a transcriptional repressor which contributes to oncogenesis. Recent research has revealed the key role of aberrant EZH2 hyper-activity in human gliomas. Here, we examined the role of the lesser-known PRC2-associated PHD Fi...

journal_title：Biochemical and biophysical research communications

authors： Lu J,Ji H,Tang H,Xu Z

更新日期：2018-09-10 00:00:00

abstract：:Atriopeptin (AP) is synthesized and stored in the mammalian atria as a 126 amino acid prohormone (AP126). Upon secretion, the prohormone undergoes site specific proteolysis within the atria to yield the carboxyl terminal 28 amino acid hormone (AP28). The atrial cell responsible for AP126 bioactivation has not yet been...

journal_title：Biochemical and biophysical research communications

authors： Greenwald JE,Needleman P,Siegel N,Tetens E,Biel B,Ritter D

更新日期：1992-10-30 00:00:00

abstract：:CRTH2, the second receptor for prostaglandin D(2) (PGD(2)), is thought to play a role in allergic inflammations through the induction of chemotactic migration and/or the activation of Th2, eosinophils, and basophils, in humans. We previously identified the mouse CRTH2 homolog of human CRTH2 and suggest that animal mod...

journal_title：Biochemical and biophysical research communications

authors： Hirai H,Abe H,Tanaka K,Takatsu K,Sugamura K,Nakamura M,Nagata K

更新日期：2003-08-08 00:00:00

abstract：:The application of Fast Atom Bombardment Mass Spectrometry to the measurement of small differences in molecular weight is discussed in relation to the spectra of bovine proinsulin and a genetic variant. ...

journal_title：Biochemical and biophysical research communications

authors： Cottrell JS,Frank BH

更新日期：1985-03-29 00:00:00

abstract：:We have obtained the complete coding sequence of a highly conserved heparan sulfate proteoglycan which we previously characterized biochemically after isolation from rat brain. An open reading frame of 558 amino acids encodes a protein with a molecular mass of 62 kDa containing three peptide sequences present in the i...

journal_title：Biochemical and biophysical research communications

authors： Karthikeyan L,Maurel P,Rauch U,Margolis RK,Margolis RU

更新日期：1992-10-15 00:00:00