Casein kinase II is required for the spindle assembly checkpoint by regulating Mad2p in fission yeast.

abstract：:Transcription factor IIA (TFIIA) is a necessary component of many RNA polymerase II transcription complexes. Assembly of the transcription complex begins when TFIIA interacts with the promoter. We have previously purified wheat germ TFIIA to homogeneity and demonstrated that it substitutes for human TFIIA in a human i...

journal_title：Biochemical and biophysical research communications

authors： Yu XB,Burke C,Zhang J,Marchitelli LJ,Davis EA,Ackerman S

更新日期：1990-04-30 00:00:00

abstract：:The mRNA coding for thyroglobulin in cattle homozygous for an autosomal recessive defect of thyroglobulin synthesis was investigated using a recombinant plasmid containing bovine mRNA coding sequence. Total RNA preparations from goiter contained one third of the thyroglobulin mRNA sequences found in normal thyroid tis...

journal_title：Biochemical and biophysical research communications

authors： Ricketts MH,Vandenplas S,van der Walt M,van Jaarsveld PP,Bester AJ,Boyd CD

更新日期：1985-01-16 00:00:00

abstract：:Autophagy has been associated with a variety of diseases especially aging. Human dermal fibroblasts (HDFs) can internalize and then degrade elastin, collagen and advanced glycation end products (AGEs) in lysosomes, which plays prominent roles in extracellular matrix homeostasis and AGEs removal in the dermis. Although...

journal_title：Biochemical and biophysical research communications

authors： Huang Y,Li Y,Qu Y,Zheng Y,Ouyang M,Zhang Y,Lai W,Xu Q

更新日期：2019-10-22 00:00:00

abstract：:High performance liquid chromatographic (HPLC) analysis showed that the prototype antioxidant ascorbate (vitamin C) inhibits the DNA adducts induced by synthetic estrogen diethylstilbestrol (DES) and the antiestrogen metabolite 4-hydroxytamoxifen (4-OHTam). Treatment of salmon testes DNA with 4-OHTam quinone or 4-OHTa...

journal_title：Biochemical and biophysical research communications

authors： Sharma M,Slocum HK

更新日期：1999-09-07 00:00:00

abstract：:Centaurin-alpha(1) was originally described as a binding partner for phosphoinositides. In spite of the presence of a putative ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) domain, no ARF-GAP activity has been attributed to centaurin-alpha(1) so far. Thus the function of this protein remains to be dete...

journal_title：Biochemical and biophysical research communications

authors： Dubois T,Zemlickova E,Howell S,Aitken A

更新日期：2003-02-07 00:00:00

abstract：:Platelets are an important place for the storage of angiogenic factors, such as vascular endothelial growth factor (VEGF) and brain-derived neurotrophic factor (BDNF). The present study aims to investigate the interaction between BDNF-TrkB pathway and platelet activation during tumor development. In an orthotopic hepa...

journal_title：Biochemical and biophysical research communications

authors： Yang ZF,Ho DW,Lau CK,Tam KH,Lam CT,Poon RT,Fan ST

更新日期：2006-08-04 00:00:00

abstract：:Quite extraordinarily molybdenum is an essential element in life for the uptake of nitrogen from both nitrogen gas and nitrate, yet it is a relatively rare heavy trace element. It also functions in a few extremely important oxygen-atom transfer reactions at low redox potential. This review poses the question "Why does...

journal_title：Biochemical and biophysical research communications

authors： Williams RJ,Fraústo da Silva JJ

更新日期：2002-03-29 00:00:00

abstract：:In a previous report we described Ser(1275) and Ser(1309) as autophosphorylation sites of the human insulin receptor (IR) tyrosine kinase (TK) in vitro. The question remained whether the observed phosphorylation was exclusive for the in vitro activated receptor or a more general, mechanism of the activated receptor in...

journal_title：Biochemical and biophysical research communications

authors： Tennagels N,Telting D,Parvaresch S,Maassen JA,Klein HW

更新日期：2001-03-30 00:00:00

abstract：:This study evaluated the effects of in vivo administration of human chorionic gonadotropin (hCG) on c-myc oncogene expression in Leydig cells. Sprague-Dawley rats (46-50 days old) were treated with hCG (10 units, i.p.), and purified Leydig cells were isolated 1-24 h later. HCG caused a transient elevation of c-myc mRN...

journal_title：Biochemical and biophysical research communications

authors： Lin T,Blaisdell J,Barbour KW,Thompson EA

更新日期：1988-11-30 00:00:00

abstract：:The major bovine seminal plasma protein, PDC-109 exhibits chaperone-like activity (CLA) against a variety of target proteins. The present studies show that the homologous protein from equine seminal plasma, HSP-1/2 also exhibits CLA and inhibits the thermal aggregation of target proteins such as lactate dehydrogenase,...

journal_title：Biochemical and biophysical research communications

authors： Sankhala RS,Kumar CS,Singh BP,Arangasamy A,Swamy MJ

更新日期：2012-10-12 00:00:00

abstract：:Hepatocyte expression of inducible nitric oxide synthase (iNOS) is initiated by the presence of pro-inflammatory cytokines, such as interleukin-1beta (IL-1). In the presence of oxidative stress, IL-1beta mediated hepatocyte iNOS expression and NO synthesis are significantly increased. To determine the underlying molec...

journal_title：Biochemical and biophysical research communications

authors： Kuo PC,Abe KY,Schroeder RA

更新日期：1997-05-19 00:00:00

abstract：:L1210/VCR cell line (R) was obtained by adaptation of the L1210 mouse leukaemia cells (S) to vincristine and showed P-glycoprotein (P-gp) mediated multidrug resistance (MDR). R cells were observed to be more sensitive to high external calcium as parental S. More pronounced calcium uptake was observed for R cells. More...

journal_title：Biochemical and biophysical research communications

authors： Sulová Z,Orlický J,Fiala R,Dovinová I,Uhrík B,Seres M,Gibalová L,Breier A

更新日期：2005-09-30 00:00:00

abstract：:The one-electron reduction product of 1-methyl-4-phenyl-2,3-dihydropyridinium ion has been generated by pulse radiolysis and its absorption spectrum recorded. This radical was found to decay by second-order kinetics (2k = 9.5 x 10(8) M-1 s-1) to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenyl-2,3-di...

journal_title：Biochemical and biophysical research communications

authors： Chacón JN,Chedekel MR,Land EJ,Truscott TG

更新日期：1989-01-16 00:00:00

abstract：:The conversion of the endogenous cellular prion protein to an abnormally folded isoform is a hallmark of transmissible spongiform encephalopathies. It occurs when a misfolded prion protein contacts the cellular PrP. Among the molecular partners suggested to be involved in the misfolding process, the glycosaminoglycans...

journal_title：Biochemical and biophysical research communications

authors： Martin R,Chantepie S,Chapuis J,Le-Duc A,Maftah A,Papy-Garcia D,Laude H,Petit JM,Gallet PF

更新日期：2011-10-28 00:00:00

abstract：:Peptides containing phosphonate based non-hydrolyzable phosphotyrosyl (pTyr) mimetics previously have been shown to be competitive inhibitors of protein-tyrosine phosphatases (PTPs). These agents suffer from low cellular penetration which is partially attributable to ionization of the phosphonate group at physiologica...

journal_title：Biochemical and biophysical research communications

authors： Kole HK,Akamatsu M,Ye B,Yan X,Barford D,Roller PP,Burke TR Jr

更新日期：1995-04-26 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPAR gamma) belongs to a nuclear receptor super family that functions as a master regulator of adipocyte differentiation. PPAR gamma binds its DNA response element together with a partner, retinoid X receptor (RXR), in fat cells. Five RXR ligands (HX600, HX630, DA022, ...

journal_title：Biochemical and biophysical research communications

authors： Sato M,Yajima Y,Kawashima S,Tanaka K,Kagechika H

更新日期：2001-01-26 00:00:00

abstract：:The surface receptor CUB domain-containing protein 1 (CDCP1) is highly expressed in several adenocarcinomas and speculated to participate in anchorage-independent cell survival and cell motility. Tyrosine kinase phosphorylation seems to be crucial for intracellular signaling of CDCP1. Lapatinib, a tyrosine kinase inhi...

journal_title：Biochemical and biophysical research communications

authors： Seidel J,Kunc K,Possinger K,Jehn C,Lüftner D

更新日期：2011-10-14 00:00:00

abstract：:VDR regulates gene expression in a ligand-dependent way by binding to cognate enhancer elements of target gene promoters. The ligand-dependent activation function, AF-2, of VDR is thought to require transcriptional co-activators/co-repressors together with basal transcriptional machinery. Using a yeast two hybrid syst...

journal_title：Biochemical and biophysical research communications

authors： Imai T,Matsuda K,Shimojima T,Hashimoto T,Masuhiro Y,Kitamoto T,Sugita A,Suzuki K,Matsumoto H,Masushige S,Nogi Y,Muramatsu M,Handa H,Kato S

更新日期：1997-04-28 00:00:00

abstract：:Electrophoretic mobility shift assays revealed minimal levels of NF-kappaB activity in rat distal lung epithelial cells cultured at fetal (23 mmHg) or adult alveolar (100 mmHg) P(O2), but revealed significant activation of this transcription factor in cells exposed to a rise in P(O2) mimicking that experienced at birt...

journal_title：Biochemical and biophysical research communications

authors： Haddad JJ,Collett A,Land SC,Olver RE,Wilson SM

更新日期：2001-03-09 00:00:00

abstract：:Multiple sclerosis (MS) has been documented to have various clinical and pathological presentations. However the underlying mechanisms remain unknown. Viral infections may play a certain role in the etiopathogenesis of MS. This study was designed to explore whether different phospholipid peptides and viral mimic pepti...

journal_title：Biochemical and biophysical research communications

authors： Zheng MM,Zhang XH

更新日期：2014-01-17 00:00:00

abstract：:Here we analyzed Pfkfb3 and Pfkfb4 gene expression in rat testis development, isolated testicular cells and spermatozoa. Real time RT-PCR analysis during testis development showed the maximum expression of Pfkfb3 in pre-puber samples and of Pfkfb4 in adult samples. Western blot analysis showed that uPFK-2 protein, a p...

journal_title：Biochemical and biophysical research communications

authors： Gómez M,Navarro-Sabaté A,Manzano A,Duran J,Obach M,Bartrons R

更新日期：2009-09-18 00:00:00

abstract：:The transcription-independent p53-mediated apoptotic response has obtained a solid mechanistic basis in recent years. A fraction of stress-induced wild type p53 protein rapidly translocates to mitochondria in response to genotoxic, hypoxic, and oxidative stresses in established cell lines and primary cells, as well as...

journal_title：Biochemical and biophysical research communications

authors： Erster S,Moll UM

更新日期：2005-06-10 00:00:00

abstract：:A novel serine proteinase inhibitor has been purified to homogeneity from the skeletal muscle of white croaker (Argyrosomus argentatus). The purification was carried out by ammonium sulfate fractionation, DEAE-Sephacel, heating treatment followed by column chromatographies on SP-Sepharose, Sephadex G-150 and gel-filtr...

journal_title：Biochemical and biophysical research communications

authors： Cao MJ,Osatomi K,Matsuda R,Ohkubo M,Hara K,Ishihara T

更新日期：2000-06-07 00:00:00

abstract：:Among the members of the additional sex comb-like (ASXL) family, ASXL3 remains unexplored. Here, we showed that ASXL3 interacts with HP1α and LSD1, leading to transcriptional repression. We determined that ASXL3 depletion augments the ligand-induced transcriptional activities of LXRα and TRβ, which were repressed by A...

journal_title：Biochemical and biophysical research communications

authors： Shin N,Lee YK,Park UH,Jeong JC,Um SJ

更新日期：2014-11-28 00:00:00

abstract：:Proteins with expanded polyglutamine domains cause eight inherited neurodegenerative diseases including Huntington's disease. In a previous paper, we identified peptides that inhibit polyglutamine protein aggregation and cell death and now describe the amino acid sequence requirements necessary for these activities. T...

journal_title：Biochemical and biophysical research communications

authors： Ren H,Nagai Y,Tucker T,Strittmatter WJ,Burke JR

更新日期：2001-11-02 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have been isolated from various tissues and used for elucidating the pathogenesis of numerous diseases. In our previous in vitro study, we showed the existence of MSCs in human spinal ligaments and hypothesized that these MSCs contributed to the pathogenesis of ossification of spinal liga...

journal_title：Biochemical and biophysical research communications

authors： Chin S,Furukawa K,Ono A,Asari T,Harada Y,Wada K,Tanaka T,Inaba W,Mizukami H,Motomura S,Yagihashi S,Ishibashi Y

更新日期：2013-07-12 00:00:00

abstract：:The involvement of vitamin D in prostate carcinogenesis was investigated using the human prostatic LNCaP cells. Incubation of the LNCaP with 100 nM 1 alpha,25-dihydroxyvitamin D3 for 2 days resulted in a 30-40% suppression of cell growth, which was accompanied by a greater than 70% down-regulated expression of the pro...

journal_title：Biochemical and biophysical research communications

authors： Hsieh TY,Ng CY,Mallouh C,Tazaki H,Wu JM

更新日期：1996-06-05 00:00:00

abstract：:The distribution of SQSC1 mRNA in tissues of squid Loligo bleekeri was studied by the blot hybridization method. The complete cDNA for the coding region of SQSC1, the invertebrate putative sodium channel, was prepared from squid optic lobe (Sato and Matsumoto, Biochem. Biophys. Res. Comm. 186, 61-68, 1992). Transcript...

journal_title：Biochemical and biophysical research communications

authors： Sato C,Hirota K,Matsumoto G

更新日期：1995-01-26 00:00:00

abstract：:We examined the effect of Mdm2 on regulation of the ApoCIII promoter and its cross-talk with p53 and nuclear receptor SHP. Overexpression of Mdm2 markedly enhanced ApoCIII promoter activity by HNF4α. A direct association of Mdm2 protein with the HNF4α protein was observed by co-immunoprecipitation. Ectopic expression ...

journal_title：Biochemical and biophysical research communications

authors： Yang Z,Zhang Y,Wang L

更新日期：2012-01-13 00:00:00

abstract：:Platelet adhesion to VLDL, LDL, HDL, and to a mixture of purified apolipoproteins was examined. Platelets adhered to all the classes of lipoproteins tested. VLDL and the apolipoprotein mixture promoted the greatest degree of adhesion. Platelet adhesion was inhibited by addition of EDTA, RGD-containing peptides and ant...

journal_title：Biochemical and biophysical research communications

authors： Kowalska MA,Tuszynski GP,Capuzzi DM

更新日期：1990-10-15 00:00:00