Mdm2 is a novel activator of ApoCIII promoter which is antagonized by p53 and SHP inhibition.

abstract：:In RBL-2H3 rat basophilic leukemia cells, Fc epsilon R1 crosslinking by multivalent antigen stimulates phosphatidylinositol (PI) turnover and Ca2+ influx and causes functional responses that include secretion, membrane ruffling and actin polymerization. Here, we show that the tyrosine kinase inhibitor, genistein, inhi...

journal_title：Biochemical and biophysical research communications

authors： Deanin GG,Martinez AM,Pfeiffer JR,Gardner ME,Oliver JM

更新日期：1991-08-30 00:00:00

abstract：:To develop antibodies against the plasma membrane 3,3',5-triiodo-L-thyronine (T3) binding protein (M.W. 55,000), rabbits were immunized with formalin-fixed GH3 cells or highly purified plasma membranes from these cells. Antibodies were screened by immunoprecipitation using detergent solubilized N-bromoacetyl-[125I]T3-...

journal_title：Biochemical and biophysical research communications

authors： Hasumura S,Rossi B,Alderson R,Pastan I,Cheng S

更新日期：1984-11-14 00:00:00

abstract：:Cardiac development requires the action of transcription factors, which control the specification and differentiation of cardiac cell types. One of these factors, encoded by the homeobox gene tinman (tin), is essential for the specification of all cardiac cells in Drosophila. An increasing number of examples show that...

journal_title：Biochemical and biophysical research communications

authors： Zaffran S,Frasch M

更新日期：2005-08-26 00:00:00

abstract：:The small heat shock protein hsp27 is associated with aggressive tumor behavior in certain subsets of breast cancer patients. Previously we demonstrated that hsp27 overexpression in breast cancer cells increased in vitro and in vivo invasiveness, suggesting that hsp27 influences the metastatic process. To investigate ...

journal_title：Biochemical and biophysical research communications

authors： Hansen RK,Parra I,Hilsenbeck SG,Himelstein B,Fuqua SA

更新日期：2001-03-23 00:00:00

abstract：:In Alzheimer's disease a small fragment of the amyloid protein precursor (APP), called beta 4, is a characteristic component of senile plaques in brains of affected patients. Efforts to intervene in Alzheimer's disease include approaches by which APP levels can be decreased in brain. The study described here demonstra...

journal_title：Biochemical and biophysical research communications

authors： Yang F,Jansen L,Friedrichs WE,Buchanan JM,Bowman BH

更新日期：1993-03-31 00:00:00

abstract：:Reversion of adenine auxotrophic strains of D. radiodurans by cross-links in DNA was studied. Mutation was induced in a wild-type but not in a mitomycin C sensitive mutant after irradiation with near UV (approximately 365nm) in the presence of 4,5',8-trimethylpsoralen (TMP). To get information on implication of cross-...

journal_title：Biochemical and biophysical research communications

authors： Yatagai F,Kitayama S

更新日期：1983-04-29 00:00:00

abstract：:Resistin, an adipocyte secreted cysteine rich hormone has been implicated as molecular link between obesity and type 2 diabetes in a murine model. Although, at the protein level mouse and human resistin show remarkable similarities with respect to conserved cysteine residues, the physiological role of human resistin i...

journal_title：Biochemical and biophysical research communications

authors： Raghu P,Ghosh S,Soundarya K,Haseeb A,Aruna B,Ehtesham NZ

更新日期：2004-01-16 00:00:00

abstract：:SIRT5 is one of the seven mammalian sirtuins which are NAD+-dependent deacylases. In human beings, SIRT5 gene encodes for four SIRT5 protein isoforms, namely SIRT5iso1, SIRT5iso2, SIRT5iso3, and SIRT5iso4. Previous studies have focused mostly on SIRT5iso1. Characteristics regarding localization, activity and tissue di...

journal_title：Biochemical and biophysical research communications

authors： Du Y,Hu H,Hua C,Du K,Wei T

更新日期：2018-09-05 00:00:00

abstract：:PmrA/PmrB and PhoP/PhoQ are a pair of two-component systems (TCSs) that allow the Gram-negative bacteria to survive the cationic antimicrobial peptide polymyxin B. The two TCSs are linked by the polymyxin resistance protein, PmrD. The PhoP-activated PmrD protects the phosphorylated response regulator PmrA from dephosp...

journal_title：Biochemical and biophysical research communications

authors： Fu W,Yang F,Kang X,Zhang X,Li Y,Xia B,Jin C

更新日期：2007-10-05 00:00:00

abstract：:Rhodamine 123, a laser dye, has been demonstrated to inhibit import of the precursor to pyridine dinucleotide transhydrogenase into mitochondria in rat liver cells. When rat hepatocytes were labeled with 35[S] methionine in the presence of 0.4 mM rhodamine 123, the precursor to transhydrogenase was found to have a hal...

journal_title：Biochemical and biophysical research communications

authors： Lubin IM,Wu LN,Wuthier RE,Fisher RR

更新日期：1987-04-14 00:00:00

abstract：:We have developed a new and rapid immunofluorescent method for visualisation of replicated regions on fixed DNA fibers. Using this method we have found in 5-fluorodeoxyuridine (FrdU)-blocked human cells distinct replication units covering about 60 kb of DNA and corresponding in size to single replicons or chromatin lo...

journal_title：Biochemical and biophysical research communications

authors： Tomilin N,Rosanov Yu,Zenin V,Bozhkov V,Vig B

更新日期：1993-01-15 00:00:00

abstract：:Adipose tissue is an active endocrine organ producing a variety of cytokines and chemokines, which may be involved in the deregulation of glucose and lipid homeostasis as well as in the inflammatory state observed in obesity. We have shown previously that differentiated human adipocytes secrete a variety of cytokines ...

journal_title：Biochemical and biophysical research communications

authors： Sell H,Dietze-Schroeder D,Eckardt K,Eckel J

更新日期：2006-05-12 00:00:00

abstract：:The vacuolar proton ATPase (V-ATPase) translocates protons into intracellular organelles or across the plasma membrane of specialised cells such as osteoclast and renal intercalated cells. The catalytic site of the V-ATPase consists of a hexamer of three A subunits and three B subunits which bind and hydrolyse ATP and...

journal_title：Biochemical and biophysical research communications

authors： van Hille B,Vanek M,Richener H,Green JR,Bilbe G

更新日期：1993-11-30 00:00:00

abstract：:Although the first members of the Schlafen gene family were first described almost 10 years ago, the precise molecular/biochemical functions of the proteins they encode still remain largely unknown. Roles in cell growth, haematopoietic cell differentiation, and T cell development/maturation have, with some experimenta...

journal_title：Biochemical and biophysical research communications

authors： Neumann B,Zhao L,Murphy K,Gonda TJ

更新日期：2008-05-23 00:00:00

abstract：:The Notch protooncogene encodes a receptor important for determination and differentiation of many cell types, and is conserved between vertebrates and invertebrates. It has been suggested that the secreted protein scabrous (sca) might be a Notch ligand acting in the peripheral nervous system. The sca protein was puri...

journal_title：Biochemical and biophysical research communications

authors： Lee EC,Baker NE

更新日期：1996-08-23 00:00:00

abstract：:The ability of a myeloid leukemia cell line (HL-60) to undergo membrane electrical potential changes was followed during neutrophilic differentiation induced by 2 compounds. Membrane-potential changes were induced with 12-O-tetradecanoylphorbol 13-acetate (TPA) or formyl-methionyl-leucyl-phenylalanine (FMLP) and were ...

journal_title：Biochemical and biophysical research communications

authors： Brown GE,Fischkoff SA,Ordonez JV

更新日期：1984-09-28 00:00:00

abstract：:Prion protein (PrPc) is expressed in many tissues, both in human and animals. The scrapie isoform of PrPc has been shown to cause neurodegeneration. In other studies it has been demonstrated that overexpression of the PrP gene can result in nonneuronal tissue degradation. Little is known, however, about the normal fun...

journal_title：Biochemical and biophysical research communications

authors： Kniazeva M,Orman R,Terranova VP

更新日期：1997-05-08 00:00:00

abstract：:Antibody-based targeted therapy of cancers requires the antibody targeting of specific molecules inducing tumor cells apoptosis or death. Angiopoietin-2 (Agn-2) and translocator protein (TSPO) are identified as potential target molecules for glioblastoma therapy. The single chain anti-Agn-2 antibody (Anag-2) and anti-...

journal_title：Biochemical and biophysical research communications

authors： Li J,Zhang Z,Lv L,Qiao H,Chen X,Zou C

更新日期：2016-04-01 00:00:00

abstract：:Human Cla-1 is the likely homologue of the murine scavenger receptor class B type I (SR-BI). SR-BI mediates selective transfer of cholesterol to high-density lipoprotein (HDL) and the efflux of endogenously synthesized and plasma membrane sterols to HDL. HDL protects against atherosclerosis but also reduces endotoxic ...

journal_title：Biochemical and biophysical research communications

authors： Buechler C,Ritter M,Quoc CD,Agildere A,Schmitz G

更新日期：1999-08-19 00:00:00

abstract：:Studies suggest that the anticancer drugs VP16-213 and VM26 produce cytotoxicity by inducing protein-associated DNA breakage in vivo through interaction with a yet unknown nuclear component. The effects of these drugs and their congeners on topoisomerase activities was investigated. VP16-213, VM26, and congeners activ...

journal_title：Biochemical and biophysical research communications

authors： Minocha A,Long BH

更新日期：1984-07-18 00:00:00

abstract：:Carcinoembryonic antigen (CEA), a widely used tumor marker, is attached by a glycosylphosphatidylinositol (GPI) anchor motif to the cell membrane. Recent study suggested that membrane-bound CEA might be cleaved by glycosylphosphatidylinositol-phospholipase D (GPI-PLD). We studied the effect of GPI-PLD on the cleavage ...

journal_title：Biochemical and biophysical research communications

authors： Yamamoto Y,Hirakawa E,Mori S,Hamada Y,Kawaguchi N,Matsuura N

更新日期：2005-07-22 00:00:00

abstract：:The effects of trace acetylation on the contact sites in peptide-antibody binding have been investigated by using a label selection method. A 13-residue synthetic peptide having three lysines (LKLVEQQNPKVKL) corresponding to sequence position 155-168 of beta 1,4-galactosyltransferase was used in this study. The four a...

journal_title：Biochemical and biophysical research communications

authors： Yadav SP,Rawitch AB

更新日期：1994-12-30 00:00:00

abstract：:Tumor cell extravasation into the brain requires passage through the blood-brain barrier, which is a highly protected microvascular environment fortified with tight junction (TJ) proteins. TJ integrity can be regulated under physiological and pathophysiological conditions. There is evidence that exercise can modulate ...

journal_title：Biochemical and biophysical research communications

authors： Wolff G,Davidson SJ,Wrobel JK,Toborek M

更新日期：2015-08-07 00:00:00

abstract：:The serine/threonine kinase mammalian target of rapamycin (mTOR) is stimulated by insulin, growth factors and nutrients and confers survival of several cell types. The kinase has previously been shown to stimulate amino acid uptake. In neurons, the cellular uptake of glutamate by the excitatory amino-acid transporters...

journal_title：Biochemical and biophysical research communications

authors： Almilaji A,Pakladok T,Guo A,Munoz C,Föller M,Lang F

更新日期：2012-05-04 00:00:00

abstract：:At 10 microM, 1-0-oleoyl-, 1-0-palmitoyl-, and 1-0-myristoyl-2-0-acetyl-glycerol weakly stimulated neutrophils to release lysozyme, an enzyme in secondary granules, but had no such effect on the release of a primary granule enzyme, beta-glucuronidase. The glycerides (1-10 microM) had a second effect on both granule po...

journal_title：Biochemical and biophysical research communications

authors： O'Flaherty JT,Schmitt JD,McCall CE,Wykle RL

更新日期：1984-08-30 00:00:00

abstract：:Formation of endothelium-derived relaxing factor (EDRF) strictly correlates with the intracellular free Ca2+ ([Ca2+]i) concentration. We now demonstrate that the histamine-induced rise in [Ca2+]i of human umbilical vein endothelial cells is mostly due to activation of a membrane current which allows Ca2+ entry. This m...

journal_title：Biochemical and biophysical research communications

authors： Graier WF,Groschner K,Schmidt K,Kukovetz WR

更新日期：1992-08-14 00:00:00

abstract：:Human bone marrow cells express both a truncated and full-length form of the erythropoietin receptor (EpoR-T and EpoR-F, respectively). Transfection experiments using the murine interleukin (IL)-3-dependent cell line, Ba/F3, revealed that the cells coexpressing EpoR-F and EpoR-T (Ba/F3-FT) were more likely to undergo ...

journal_title：Biochemical and biophysical research communications

authors： Shimizu R,Komatsu N,Nakamura Y,Nakauchi H,Nakabeppu Y,Miura Y

更新日期：1996-05-06 00:00:00

abstract：:Tau misfolding has been implicated in a variety of tauopathies, including Alzheimer's disease. The microtubule binding domain of tau consists of four repeat segments (R1-R4), and aggregation of these segments leads to the formation of neurofibrillary tangles. Previous studies indicate that misfolded tau associates wit...

journal_title：Biochemical and biophysical research communications

authors： Dicke SS,Tatge L,Engen PE,Culp M,Masterson LR

更新日期：2017-12-02 00:00:00

abstract：:Approximately 80% of ovarian cancer (OC) is diagnosed at late stages, and most patients die within 5 years of diagnosis due to recurrence or drug resistance. Novel treatments are required to improve patient survival. Immune therapy against cancer is promising; however, therapeutic vaccination has been limited by the i...

journal_title：Biochemical and biophysical research communications

authors： Yu W,Qu H,Cao G,Liu C,Deng H,Zhang Z

更新日期：2017-12-09 00:00:00

abstract：:In probing the possible non-genotoxic molecular mechanism(s) of nickel(II)-induced carcinogenesis, we performed a non-radioactive mRNA differential display analysis for nickel(II) acetate-treated Chinese hamster ovary cells (CHO-K1-BH4). Three out of thirty differentially expressed cDNAs had sequences highly similar t...

journal_title：Biochemical and biophysical research communications

authors： Lee SH,Shiao YH,Plisov SY,Kasprzak KS

更新日期：1999-05-19 00:00:00