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Mdm2 is a novel activator of ApoCIII promoter which is antagonized by p53 and SHP inhibition.

Abstract：

:We examined the effect of Mdm2 on regulation of the ApoCIII promoter and its cross-talk with p53 and nuclear receptor SHP. Overexpression of Mdm2 markedly enhanced ApoCIII promoter activity by HNF4α. A direct association of Mdm2 protein with the HNF4α protein was observed by co-immunoprecipitation. Ectopic expression of p53 decreased HNF4α activation of the ApoCIII promoter and antagonized the effect of Mdm2. Co-expression of SHP further strengthened p53 inhibition and abolished Mdm2 activation of the ApoCIII promoter. Mdm2 inhibited p53-mediated enrichment of HNF4α to the ApoCIII promoter while simultaneously reducing p53 binding and increasing recruitment of SHP to the ApoCIII promoter. The results from this study implicate a potentially important function of Mdm2 in regulation of lipoprotein metabolism.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Yang Z,Zhang Y,Wang L

doi

10.1016/j.bbrc.2011.12.027

subject

Has Abstract

pub_date

2012-01-13 00:00:00

pages

744-6

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(11)02236-4

journal_volume

417

pub_type

杂志文章

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