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Cystathionine gamma lyase-H2S contributes to osteoclastogenesis during bone remodeling induced by mechanical loading.

Abstract：

:Hydrogen sulfide (H2S), a gaseous signaling molecule produced by cystathionine γ-lyase (CSE) and cystathionine β-synthase (CBS), influences bone remodeling in many ways. Osteoclasts play an important role in bone remodeling during tooth movement induced by mechanical loading, which increases the rate of tooth movement. Recently, we found that osteoclasts could produce H2S. However, whether H2S modulates bone remodeling by affecting osteoclasts remains unclear. In this study, we found that CSE-H2S was a dominant H2S generating system in osteoclasts, while CBS did not generate H2S. A significant increase in CSE mRNA expression and H2S production was observed in periodontal ligament (PDL) tissues of wild-type (WT) mice after 3 days of mechanical loading. CSE gene knockout led to a significant reduction in the number of maxillary osteoclasts and in the amount of tooth movement. The number of RANKL-induced TRAP-positive osteoclasts and the mRNA expression of osteoclast markers were downregulated after 6 days of incubation in monocytes extracted from CSE-/- mice. The expression of IL-1, IL-6 and TNF-α, which can stimulate osteoclastogenesis in periodontal tissue and serum samples, was lower in CSE-/- mice after mechanical loading. Application of the H2S donor GYY4137 increased the number of RANKL-induced osteoclasts, the number of osteoclasts in periodontal tissues and tooth movement distance in CSE-/- mice. The results suggested that endogenous H2S and CSE play vital roles in the osteoclastogenesis and alveolar bone resorption induced by mechanical loading.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Mo S,Hua Y

doi

10.1016/j.bbrc.2018.05.015

subject

Has Abstract

pub_date

2018-06-22 00:00:00

pages

471-477

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(18)31060-X

journal_volume

501

pub_type

杂志文章

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