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Tumor promoter inhibition of cellular binding of somatostatin.

Abstract：

:Tumor promoting phorbol esters inhibited the binding of 125I-[Tyr11] somatostatin to isolated acinar cells from guinea-pig pancreas. Maximal inhibition reached 69.7 +/- 5% at 1 microM TPA. Receptor affinity was decreased by 2.5-fold without change in binding capacity. The ability of TPA in inhibiting somatostatin binding was decreased in 30 nM Ca2+ medium, abolished at 4 degrees C or in a membrane preparation. The effect of caerulein, a secretagogue which also caused loss of binding, and that of TPA were not additive. We concluded that TPA inhibits somatostatin binding not by binding directly at the active site of somatostatin receptor. TPA may act at a later point than caerulein via a similar pathway to modulate somatostatin receptor affinity.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Zeggari M,Susini C,Viguerie N,Esteve JP,Vaysse N,Ribet A

doi

10.1016/0006-291x(85)90124-x

subject

Has Abstract

pub_date

1985-04-30 00:00:00

pages

850-7

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(85)90124-X

journal_volume

128

pub_type

杂志文章

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