当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Monoclonal antibody alpha IR-3 inhibits the ability of insulin-like growth factor II to stimulate a signal from the type I receptor without inhibiting its binding.

Monoclonal antibody alpha IR-3 inhibits the ability of insulin-like growth factor II to stimulate a signal from the type I receptor without inhibiting its binding.

Abstract：

:We have previously shown that the protein encoded by a human insulin-like growth factor I (IGF-I) receptor cDNA binds both IGF-I and II with high affinity. In the present studies, we show that a monoclonal antibody to the IGF-I receptor, alpha IR-3, inhibits the binding of IGF-I but not IGF-II to the expressed receptor in intact cells and after solubilization. Surprisingly, this monoclonal antibody inhibits the ability of both IGF-I and II to stimulate thymidine synthesis in cells with the expressed receptor. Moreover, this antibody inhibits the ability of both IGF-I and II to stimulate the kinase activity of the IGF-I receptor in intact cells. These results indicate that alpha IR-3 binds to the IGF-I receptor in such a way that it does not inhibit the binding of IGF-II but does inhibit the subsequent ability of the receptor to be activated to transmit a signal.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Steele-Perkins G,Roth RA

doi

10.1016/0006-291x(90)90819-9

subject

Has Abstract

pub_date

1990-09-28 00:00:00

pages

1244-51

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(90)90819-9

journal_volume

171

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • High density cultures of embryoid bodies enhanced cardiac differentiation of murine embryonic stem cells.

    abstract：:Murine embryonic stem cell (mESC)-derived cardiomyocytes represent a promising source of cells for use in the development of models for studying early cardiac development as well as cell-based therapies in postnatal pathologies. Here, we report a highly efficient cardiac differentiation system in which high density em...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.10.140

    authors： Lee MY,Cagavi Bozkulak E,Schliffke S,Amos PJ,Ren Y,Ge X,Ehrlich BE,Qyang Y

    更新日期：2011-12-09 00:00:00

  • Protein-ligand interactions: interaction of nitrosamines with nicotinic acetylcholine receptor.

    abstract：:Fluorimetry and spectrophotometry have been used to study the binding of dimethyl, dipropyl, dibutyl and diphenylnitrosamine to nicotinic acetylcholine receptor isolated, and purified, from Torpedo fuscomaculata. Scatchard analysis indicates that all four ligands are true agonists of the receptor exhibiting positive c...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)90676-e

    authors： Kapp EA,Daya S,Whiteley CG

    更新日期：1990-03-30 00:00:00

  • Retinoic acid treatment of human neuroblastoma cells is associated with decreased N-myc expression.

    abstract：:Cells from human neuroectodermal tumors (retinoblastoma and neuroblastoma) and from neuroblastoma cell lines express a gene, N-myc, which is frequently amplified in these tumors. We report here that N-myc mRNA content is markedly decreased in cells of a neuroblastoma cell line (LA-N-5) following differentiation induce...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)90311-0

    authors： Amatruda TT 3rd,Sidell N,Ranyard J,Koeffler HP

    更新日期：1985-02-15 00:00:00

  • Site-directed mutation on the only universally conserved residue Leu122 of small heat shock protein Hsp16.3.

    abstract：:Hsp16.3 from Mycobacterium tuberculosis belongs to the small heat shock protein family and has chaperone-like activity in vitro. The only universally conserved hydrophobic residue Leu122 was substituted by Val and Ala, respectively. The mutations on the Leu122 of Hsp16.3 have resulted in much lower structural stabilit...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.6062

    authors： Mao Q,Chang Z

    更新日期：2001-12-21 00:00:00

  • Activation of mitochondrial μ-calpain increases AIF cleavage in cardiac mitochondria during ischemia-reperfusion.

    abstract：:Ubiquitous calpains (calpain I and II) are generally recognized as cytosolic proteins. Recently, mitochondrial localized calpain I (μ-calpain) has been identified. Activation of mito-μ-calpain cleaves apoptosis inducing factor (AIF), a flavoprotein located within the mitochondrial intermembrane space, in liver mitocho...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.10.037

    authors： Chen Q,Paillard M,Gomez L,Ross T,Hu Y,Xu A,Lesnefsky EJ

    更新日期：2011-12-02 00:00:00

  • 1-0-Hexadecyl-2-acetyl-sn-glycerol stimulates differentiation of HL-60 human promyelocytic leukemia cells to macrophage-like cells.

    abstract：:The human promyelocytic leukemia cell line HL-60 can be differentiated to cells resembling either neutrophils or mononuclear phagocytes by a diverse group of stimuli. However, the underlying mechanisms remain unknown. We report that 1-0-hexadecyl-2-acetyl-sn-glycerol inhibits the growth of HL-60 cells and induces diff...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(84)80108-4

    authors： McNamara MJ,Schmitt JD,Wykle RL,Daniel LW

    更新日期：1984-07-31 00:00:00

  • Oxidative stress increases gene expression of heparin-binding EGF-like growth factor and amphiregulin in cultured rat gastric epithelial cells.

    abstract：:We investigated the effects of oxidative stress on mRNA levels of heparin-binding epidermal growth factor-like growth factor (HB-EGF) and amphiregulin (AR) in rat gastric epithelial RGM1 cells. In response to stimulation with hydrogen peroxide (100-400 microM), gene expression of HB-EGF and AR increased in a dose-depe...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.1391

    authors： Miyazaki Y,Shinomura Y,Tsutsui S,Yasunaga Y,Zushi S,Higashiyama S,Taniguchi N,Matsuzawa Y

    更新日期：1996-09-13 00:00:00

  • Icariin stimulates angiogenesis by activating the MEK/ERK- and PI3K/Akt/eNOS-dependent signal pathways in human endothelial cells.

    abstract：:We investigated the molecular effect and signal pathway of icariin, a major flavonoid of Epimedium koreanum Nakai, on angiogenesis. Icariin stimulated in vitro endothelial cell proliferation, migration, and tubulogenesis, which are typical phenomena of angiogenesis, as well as increased in vivo angiogenesis. Icariin a...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.09.001

    authors： Chung BH,Kim JD,Kim CK,Kim JH,Won MH,Lee HS,Dong MS,Ha KS,Kwon YG,Kim YM

    更新日期：2008-11-14 00:00:00

  • EphA7 modulates apical constriction of hindbrain neuroepithelium during neurulation in Xenopus.

    abstract：:Eph receptor tyrosine kinases (RTKs) and their ephrin ligands play multiple roles in the developing nervous system, including cell segregation, axon guidance and synaptic plasticity. Here we report the expression and function of EphA7 in Xenopus hindbrain development. EphA7 is specifically expressed in the hindbrain t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.09.138

    authors： Wang X,Sun J,Li C,Mao B

    更新日期：2016-10-28 00:00:00

  • Characterization by cDNA cloning of the mRNA of human ribosomal protein L8.

    abstract：:From a lambda UNI-ZAP XR cDNA library derived from poly(A)+RNA of human ovarian granulosa cells a cDNA clone pHG51 was isolated. Sequence analysis showed significant homology to the C-terminal region of rat ribosomal protein L8 cDNA. The 5'-end of the cDNA was completed by PCR with cloned total cDNA. Aligning of DNA s...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.2607

    authors： Hanes J,Klaudiny J,von der Kammer H,Scheit KH

    更新日期：1993-12-30 00:00:00

  • Calcium dependent activation of skeletal muscle Ca2+ release channel (ryanodine receptor) by calmodulin.

    abstract：:In this study terminal cisternae vesicles from rabbit skeletal muscle were fused into planar bilayers and the effect of calmodulin on single Ca2+ release channel currents was investigated. In the presence of 10(-7) and 10(-9) M free [Ca2+], nanomolar concentrations of calmodulin activated the channel by increasing the...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.2238

    authors： Buratti R,Prestipino G,Menegazzi P,Treves S,Zorzato F

    更新日期：1995-08-24 00:00:00

  • Role of protein kinase C-alpha in activation of ecto-5'-nucleotidase in the preconditioned canine myocardium.

    abstract：:We have reported that activation of protein kinase C (PKC) increases ecto-5'-nucleotidase activity, which may contribute to the infarct size-limiting effect of ischemic preconditioning. Since we have reported that Ca(2+)- and phospholipid-sensitive PKC is activated due to ischemic preconditioning, we further tested 1)...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.7445

    authors： Kitakaze M,Funaya H,Minamino T,Node K,Sato H,Ueda Y,Okuyama Y,Kuzuya T,Hori M,Yoshida K

    更新日期：1997-10-09 00:00:00

  • Activated macrophages kill pancreatic syngeneic islet cells via arginine-dependent nitric oxide generation.

    abstract：:IL-1 and TNF alpha are assumed to be major mediators of islet cell destruction during the pathogenesis of type 1 diabetes. Here we show by neutralization of the two cytokines with excess antibody that IL-1 and TNF alpha do not contribute to the cytotoxic activity of activated macrophages towards isolated islet cells. ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(91)91630-u

    authors： Kröncke KD,Kolb-Bachofen V,Berschick B,Burkart V,Kolb H

    更新日期：1991-03-29 00:00:00

  • A hydrocortisone derivative binds to GAPDH and reduces the toxicity of extracellular polyglutamine-containing aggregates.

    abstract：:Huntington's disease (HD) has been recently shown to have a horizontally transmitted, prion-like pathology. Thus, the migration of polyglutamine-containing aggregates to acceptor cells is important for the progression of HD. These aggregates contain glyceraldehyde-3-phosphate dehydrogenase (GAPDH), which increases the...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.04.125

    authors： Lazarev VF,Mikhaylova ER,Dutysheva EA,Suezov RV,Guzhova IV,Margulis BA

    更新日期：2017-06-03 00:00:00

  • Morphine-mimetic anti-paratypic antibodies: cross-reactive properties.

    abstract：:Polyclonal, anti-idiotypic, rabbit antibodies have been raised against four murine monoclonal anti-morphine Fab fragments. The antibody preparations, after affinity purification, have been shown to contain an anti-paratypic fraction which reversibly inhibits morphine binding to the anti-morphine antibodies and to cell...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(86)90458-4

    authors： Glasel JA,Pelosi LA

    更新日期：1986-05-14 00:00:00

  • Pentamethylquercetin protects against cardiac remodeling via activation of Sestrin2.

    abstract：:Oxidative stress is widely involved in pathophysiological processes of cardiac remodeling. Molecules associated with antioxidant functions may be ideal targets for reversing cardiac remodeling. Sestrin2 is the important component of endogenous antioxidant defense, while there is little information on the pathophysiolo...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.03.031

    authors： Du JX,Wu JZ,Li Z,Zhang C,Shi MT,Zhao J,Jin MW,Liu H

    更新日期：2019-04-30 00:00:00

  • Photosynthetic oxygen evolution does not require the participation of polypeptides of 16 and 24 kilodaltons.

    abstract：:Oxygen evolution from Triton X-100 prepared photosystem II particles from spinach was inhibited 70-80% after treatment of the particles with high concentrations of salt (0.5 or 1 M NaCl). The salt-washed preparations were depleted of 16 and 24 kilodalton polypeptides. Nearly complete restoration of herbicide-sensitive...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(84)91448-7

    authors： Nakatani HY

    更新日期：1984-04-16 00:00:00

  • An in vivo model for study of the angiogenic effects of basic fibroblast growth factor.

    abstract：:We have investigated the angiogenic effects of basic fibroblast growth factor following its implantation in slow release beads under the kidney capsule. The presence of basic fibroblast growth factor in the subcapsular space induced a marked angiogenic response maximal at 1 microgram dose per kidney. Histological exam...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(87)91011-4

    authors： Hayek A,Culler FL,Beattie GM,Lopez AD,Cuevas P,Baird A

    更新日期：1987-09-15 00:00:00

  • Cardioprotection by modulation of mitochondrial respiration during ischemia-reperfusion: role of apoptosis-inducing factor.

    abstract：:The transient, reversible blockade of electron transport (BET) during ischemia or at the onset of reperfusion protects mitochondria and decreases cardiac injury. Apoptosis inducing factor (AIF) is located within the mitochondrial intermembrane space. A release of AIF from mitochondria into cytosol and nucleus triggers...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.05.033

    authors： Xu A,Szczepanek K,Hu Y,Lesnefsky EJ,Chen Q

    更新日期：2013-06-14 00:00:00

  • Catabolism of intact type VI collagen microfibrils: susceptibility to degradation by serine proteinases.

    abstract：:We present the first direct biochemical evidence for the turnover of intact type VI collagen microfibrils. Matrix-degrading enzymes of the serine proteinase class, including rat mast cell chymases I and II, human mast cell tryptase, neutrophil elastase, cathepsin G and trypsin, were able to catabolize intact type VI c...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.1349

    authors： Kielty CM,Lees M,Shuttleworth CA,Woolley D

    更新日期：1993-03-31 00:00:00

  • Transduction of anti-apoptotic proteins into chondrocytes in cartilage slice culture.

    abstract：:Peptides of the protein transduction domain (PTD) mediate the introduction of passenger proteins into cells in vitro and in vivo, where the domains are positively charged. This unusual ability can be exploited for medical applications in protein therapeutics. Chondrocytes are embedded in a dense extracellular matrix, ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2003.11.144

    authors： Ozaki D,Sudo K,Asoh S,Yamagata K,Ito H,Ohta S

    更新日期：2004-01-16 00:00:00

  • Bowline mediates association of the transcriptional corepressor XGrg-4 with Tbx6 during somitogenesis in Xenopus.

    abstract：:Prior to the somite segmentation, the cells in the anterior presomitic mesoderm (PSM) express a set of genes that is required for defining the segmental border and polarity of the prospective somite. However, little is known how the expression of these genes is repressed upon segmentation. Here we report that Bowline,...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.05.211

    authors： Kondow A,Hitachi K,Okabayashi K,Hayashi N,Asashima M

    更新日期：2007-08-10 00:00:00

  • Abnormal signalling of 14-3-3 proteins in cells with accumulated xanthurenic acid.

    abstract：:Xanthurenic acid is an endogenous molecule leading to caspase-9 and -3 activation. Here we report that xanthurenic acid targets signalling proteins 14-3-3 into lysosomes leading to interruption protein/protein interaction. Xanthurenic acid changed the localisation of 14-3-3 in the cells. At a concentration of 10 and 2...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2003.09.060

    authors： Malina HZ,Frueh BE

    更新日期：2003-10-17 00:00:00

  • The WNT inhibitor APCDD1 sustains the expression of β-catenin during the osteogenic differentiation of human dental follicle cells.

    abstract：:In hair follicle cells APCDD1 inhibits the canonical WNT/β-Catenin pathway and its inactivation is associated with an autosomal dominant form of hair loss. We analyzed the role of APCDD1 for the osteogenic differentiation in dental follicle cells (DFCs) and identified a new and surprising function. Contrarily to hair ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.12.107

    authors： Viale-Bouroncle S,Klingelhöffer C,Ettl T,Morsczeck C

    更新日期：2015-02-13 00:00:00

  • Effect of hexadecane on piglet epidermal ornithine decarboxylase activity.

    abstract：:Topical application of hexadecane has been shown to induce hyperproliferation and hyperkeratosis in rodent skin. The application of hexadecane to epidermis from the backs of piglets less than 1 week old resulted in a rapid biphasic-rise in the level of ornithine decarboxylase (ODC) activity. The second phase of the el...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)91383-1

    authors： Owusu S,Cunliffe WJ,Wood EJ

    更新日期：1989-06-30 00:00:00

  • Induction of the lutropin/choriogonadotropin receptor in rat ovary during luteinization.

    abstract：:Molecular analysis of the induction of the lutropin/choriogonadotropin receptor during the process of luteinization of the rat ovary was performed. The appearance of receptor binding activity and an immunological analysis of the receptor using Triton solubilized membrane proteins show little receptor present in luteal...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)91177-t

    authors： Hansbury MJ,McIlroy PJ,Goldenthal MJ

    更新日期：1990-09-14 00:00:00

  • Ingestion of eicosapentaenoic acid-ethyl ester renders rabbit LDL less susceptible to Cu2(+)-catalyzed-oxidative modification.

    abstract：:The present study revealed that low density lipoprotein (LDL) obtained from rabbits fed highly purified eicosapentaenoic acid-ethyl ester (EPA-E) (EPA-LDL) was significantly less susceptible to oxidative modification catalyzed by Cu2+ as compared to LDL from rabbits fed a normal diet (control LDL). In a comparison of ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)81200-8

    authors： Saito H,Chang KJ,Tamura Y,Yoshida S

    更新日期：1991-02-28 00:00:00

  • C-Mannosylation of thrombopoietin receptor (c-Mpl) regulates thrombopoietin-dependent JAK-STAT signaling.

    abstract：:The thrombopoietin receptor, also known as c-Mpl, is a member of the cytokine superfamily, which regulates the differentiation of megakaryocytes and formation of platelets by binding to its ligand, thrombopoietin (TPO), through Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling. The l...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.10.116

    authors： Sasazawa Y,Sato N,Suzuki T,Dohmae N,Simizu S

    更新日期：2015-12-04 00:00:00

  • High D-glucose stimulates the cell cycle from the G1 to the S and M phases, but has no competent effect on the G0 phase, in vascular smooth muscle cells.

    abstract：:The effects of high (28mM) D-glucose (HG) on the cell cycle progression were investigated in rat aorta vascular smooth muscle cells (VSMCs) in primary culture, using an immunocytochemical analysis of cell-cycle-specific nuclear antigens. HG had no effect on the cell cycle of the serum-deprived G0 cells, whereas platel...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1858

    authors： Hiroishi G,Kobayashi S,Nishimura J,Inomata H,Kanaide H

    更新日期：1995-06-15 00:00:00

  • Cholesterol secoaldehyde induces apoptosis in J774 macrophages via mitochondrial pathway but not involving reactive oxygen species as mediators.

    abstract：:Cholesterol secoaldehyde (3beta-hydroxy-5-oxo-5,6-secocholestan-6-al or ChSeco) is an oxysterol known to be formed in reactions of ozone with cholesterol and also when cholesterol-5alpha-hydroperoxide undergoes Hock cleavage. In view of its widespread occurrence and atherogenic potential, we examined the effects of Ch...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.09.005

    authors： Gao X,Raghavamenon AC,D'Auvergne O,Uppu RM

    更新日期：2009-11-13 00:00:00