Abstract:
:Cells from human neuroectodermal tumors (retinoblastoma and neuroblastoma) and from neuroblastoma cell lines express a gene, N-myc, which is frequently amplified in these tumors. We report here that N-myc mRNA content is markedly decreased in cells of a neuroblastoma cell line (LA-N-5) following differentiation induced with retinoic acid. Exposure of the cells to retinoic acid induced morphologic changes consistent with neuronal differentiation, and led to a 75% decrease in expression of N-myc mRNA. These results suggest that N-myc expression is intimately related to an undifferentiated phenotype in neuroblastoma cells, and support other studies which relate N-myc expression to the malignant phenotype in neuroblastoma tumors.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Amatruda TT 3rd,Sidell N,Ranyard J,Koeffler HPdoi
10.1016/0006-291x(85)90311-0subject
Has Abstractpub_date
1985-02-15 00:00:00pages
1189-95issue
3eissn
0006-291Xissn
1090-2104pii
0006-291X(85)90311-0journal_volume
126pub_type
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