Semicarbazide-sensitive amine oxidase in transgenic mice with diabetes.

abstract：:Triple-negative breast cancer (TNBC) that lacks expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) is a breast cancer subtype with very aggressive metastasis and poor prognosis. Unique cartilage matrix-associated protein (UCMA) is a vitamin K-dependent...

journal_title：Biochemical and biophysical research communications

authors： Lee SH,Lee YJ,Park SI,Kim JE

更新日期：2020-10-01 00:00:00

abstract：:Selective modification of one (of three) tyrosine residue per enzyme monomer leads to inactivation of dUTPase of the retrovirus equine infectious anemia virus (EIAV). The substrate dUMP and the cofactor Mg2+ protect against inactivation and modification, in agreement with the study on E. coli dUTPase (Vertessy et al. ...

journal_title：Biochemical and biophysical research communications

authors： Vertessy BG,Persson R,Rosengren AM,Zeppezauer M,Nyman PO

更新日期：1996-02-15 00:00:00

abstract：:Tubulointerstitial nephritis antigen (TIN-ag) is an extracellular matrix basement protein which was originally identified as a target antigen involved in anti-tubular basement membrane (TBM) antibody-mediated interstitial nephritis (TIN). Further investigations elucidated that TIN-ag plays a role in renal tubulogenesi...

journal_title：Biochemical and biophysical research communications

authors： Ikeda M,Takemura T,Hino S,Yoshioka K

更新日期：2000-02-05 00:00:00

abstract：:The optical spectrum of Sperm Whale myoglobin, which has been freshly reconstituted with iron protoporphyrin-IX, is shown to be different from that obtained from the native myoglobin, and from the reconstituted, incubated myoglobin (These last two have equivalent absorption spectra). The effect is immediately evident ...

journal_title：Biochemical and biophysical research communications

authors： Gebe JA,Peyton DH,Peyton JA

更新日期：1989-05-30 00:00:00

abstract：:Postmenopausal women treated with estrogen hormone replacement therapy and female patients with hypoplasminogenemia receiving oral contraceptives show increasing plasminogen (PLG) concentrations. The elevated PLG levels are in contrast to the estrogen dependent decline of lipoptrotein(a) [Lp(a)], whose main protein co...

journal_title：Biochemical and biophysical research communications

authors： Kobelt L,Klammt J,Tefs K,Schuster V

更新日期：2013-08-16 00:00:00

abstract：:Hypothalamic peptides, gonadotropin-releasing hormone (GnRH) and gonadotropin inhibitory hormone (GnIH), play pivotal roles in the control of reproduction and gonadal maturation in fish. In the present study we tested the possibility that stress-mediated reproductive dysfunction in teleost may involve changes in GnRH ...

journal_title：Biochemical and biophysical research communications

authors： Choi YJ,Habibi HR,Kil GS,Jung MM,Choi CY

更新日期：2017-04-01 00:00:00

abstract：:The bromodomain and extraterminal (BET) domain family proteins are epigenetic modulators involved in the reading of acetylated lysine residues. The first BET protein inhibitor to be identified, (+)-JQ1, a thienotriazolo-1, 4-diazapine, binds selectively to the acetyl lysine-binding pocket of BET proteins. We evaluated...

journal_title：Biochemical and biophysical research communications

authors： Goupille O,Penglong T,Kadri Z,Granger-Locatelli M,Fucharoen S,Maouche-Chrétien L,Prost S,Leboulch P,Chrétien S

更新日期：2016-04-15 00:00:00

abstract：:[2-14C]-trans-2-hexadecenoyl CoA (16:1) and [2-14C]-trans-2-cis-8,11,14-eicosatetraenoyl CoA (20:4) were chemically synthesized and employed as competitive substrates for the liver microsomal trans-2-enoyl CoA reductase component of the fatty acid chain elongation system. Both 7.5 microM and 15 microM 20:4 competitive...

journal_title：Biochemical and biophysical research communications

authors： Nagi MN,Cook L,Prasad MR,Cinti DL

更新日期：1986-10-15 00:00:00

abstract：:The transient, reversible blockade of electron transport (BET) during ischemia or at the onset of reperfusion protects mitochondria and decreases cardiac injury. Apoptosis inducing factor (AIF) is located within the mitochondrial intermembrane space. A release of AIF from mitochondria into cytosol and nucleus triggers...

journal_title：Biochemical and biophysical research communications

authors： Xu A,Szczepanek K,Hu Y,Lesnefsky EJ,Chen Q

更新日期：2013-06-14 00:00:00

abstract：:The coffee-specific diterpenes cafestol and kahweol (C+K) have been identified as two important chemoprotective agents in coffee. In the present study, the potential preventive effects of C+K against the genotoxicity of B[a]P were investigated in rat primary hepatocytes and in human bronchial Beas-2B cells. Several in...

journal_title：Biochemical and biophysical research communications

authors： Cavin C,Bezencon C,Guignard G,Schilter B

更新日期：2003-06-27 00:00:00

abstract：:The extended exposure of proteins to reducing sugars leads to nonenzymatic glycation with the accumulation of advanced glycation end products (AGEs). Long-lived proteins, such as collagen and crystallins, are subjected to this modification, and are implicated as causal factors in several diseases including diabetic co...

journal_title：Biochemical and biophysical research communications

authors： Hong SB,Lee KW,Handa JT,Joo CK

更新日期：2000-08-18 00:00:00

abstract：:Mannoproteins (MPs) are a major component of yeast cell walls and consist of high levels of mannose in covalent complexes with proteins. MPs complexly enhance the immune system. We previously isolated a mutant yeast, K48L3, with a higher yield of MP from its cell wall than wild-type Saccharomyces cerevisiae, YPH499. W...

journal_title：Biochemical and biophysical research communications

authors： Yoon BH,Lee SM,Chang HI,Ha CH

更新日期：2019-11-19 00:00:00

abstract：:Akt/PKB plays a pivotal role in cell survival and proliferation. Previously, we reported that UV-irradiation induces extensive cell death in Akt2(-/-) mouse embryonic fibroblasts (MEFs) while Akt1(-/-) MEFs show cell cycle arrest. Here, we find that Akt1(-/-) MEFs exhibit phenotypic changes characteristics of senescen...

journal_title：Biochemical and biophysical research communications

authors： Jee HJ,Kim HJ,Kim AJ,Bae YS,Bae SS,Yun J

更新日期：2009-06-05 00:00:00

abstract：:Hammerhead ribozymes may be of great therapeutic importance, since they can, in theory, be developed to cleave any undesired target RNA. In order to design ribozymes which are stable against endogenous RNases, we incorporated 2'-acetamido-2'-deoxynucleosides in the catalytic core of a hammerhead ribozyme. The 2'-aceta...

journal_title：Biochemical and biophysical research communications

authors： Hendrix C,Mahieu M,Anné J,Van Calenbergh S,Van Aerschot A,Content J,Herdewijn P

更新日期：1995-05-05 00:00:00

abstract：:The natural compound ferulenol, a sesquiterpene prenylated coumarin derivative, was purified from Ferula vesceritensis and its mitochondrial effects were studied. Ferulenol caused inhibition of oxidative phoshorylation. At low concentrations, ferulenol inhibited ATP synthesis by inhibition of the adenine nucleotide tr...

journal_title：Biochemical and biophysical research communications

authors： Lahouel M,Zini R,Zellagui A,Rhouati S,Carrupt PA,Morin D

更新日期：2007-03-30 00:00:00

abstract：:Adenylate cyclase in homogenates of guinea pig ventricles was inhibited by the stable adenosine analogs N6-phenylisopropyladenosine (PIA) and 5(1)-N-ethylcarboxamidoadenosine (NECA). Inhibition required GTP and was enhanced by sodium ion. The maximum inhibition observed was 35.1 +/- 1.1%, the EC50 (95% confidence limi...

journal_title：Biochemical and biophysical research communications

authors： Leung E,Johnston CI,Woodcock EA

更新日期：1983-01-14 00:00:00

abstract：:To examine whether protein kinase C (PKC) plays a role in mediating growth inhibitory effects of hexamethylene bisacetamide (HMBA) we compared a control H29 colon cancer cell line to a derivative, HT29-PKC7, that overexpresses high levels of PKC beta 1. We found that although HMBA markedly inhibited the growth of the ...

journal_title：Biochemical and biophysical research communications

authors： Choi PM,Weinstein IB

更新日期：1991-12-16 00:00:00

abstract：:Extracellular acidic pH-activated chloride channel I(Cl, acid), has been characterized in HEK 293 cells and mammalian cardiac myocytes. This study was designed to characterize I(Cl,acid) in human umbilical vein endothelial cells(HUVECs). The activation and deactivation of the current rapidly and repeatedly follows the...

journal_title：Biochemical and biophysical research communications

authors： Ma ZY,Zhang W,Chen L,Wang R,Kan XH,Sun GZ,Liu CX,Li L,Zhang Y

更新日期：2008-07-04 00:00:00

abstract：:Recently, copper (Cu) was found to be unusually accumulated, suggesting the induction of metallothionein (MT) in the liver of LEC rats (Long-Evans rats with a cinnamon-like coat color), which develop spontaneous jaundice with hereditary hepatitis. Thus, the direct relationship between the unusual Cu accumulation and t...

journal_title：Biochemical and biophysical research communications

authors： Sakurai H,Kamada H,Fukudome A,Kito M,Takeshima S,Kimura M,Otaki N,Nakajima K,Kawano K,Hagino T

更新日期：1992-06-15 00:00:00

abstract：:RNA primer removal during DNA replication is dependent on ribonucleotide- and structure-specific RNase H and FEN-1 nuclease activities. A specific RNase H involved in this reaction has long been sought. RNase HII is the only open reading frame in Archaeoglobus fulgidus genome, while multiple RNases H exist in eukaryot...

journal_title：Biochemical and biophysical research communications

authors： Chai Q,Qiu J,Chapados BR,Shen B

更新日期：2001-09-07 00:00:00

abstract：:A more precise description of the binding of N-(phosphonacetyl)-L- aspartate to the catalytic chains of aspartate carbamoyltransferase clarifies aspects of the specificity of this enzyme toward its substrates, carbamoylphosphate and L-aspartate, and suggests a catalytic role for His-134. ...

journal_title：Biochemical and biophysical research communications

authors： Volź KW,Krause KL,Lipscomb WN

更新日期：1986-04-29 00:00:00

abstract：:Maximal stimulation of inositol 1,4,5 trisphosphate (IP3) production by epinephrine and carbachol in rat parotid cell aggregates is additive when the two agents are employed simultaneously. The additive response proceeds through both the alpha 1-adrenergic and muscarinic-cholinergic signal transduction pathways. It is...

journal_title：Biochemical and biophysical research communications

authors： Kowatch MA,Roth GS

更新日期：1991-05-15 00:00:00

abstract：:To elucidate whether PTH(7-84), a degradation product of PTH(1-84), which inhibits PTH(1-84)-induced bone resorption, also exerts an antagonistic effect on the kidney, we studied the effect of PTH(7-84) on PTH(1-34)-induced production of 1,25-(OH)2D3 in primary cultured murine renal tubules. Neonatal mouse renal tubul...

journal_title：Biochemical and biophysical research communications

authors： Nakajima K,Nohtomi K,Sato M,Takano K,Sato K

更新日期：2009-04-03 00:00:00

abstract：:To understand the regulation by thyroid hormone, 3,3',5-triiodo-L-thyronine (T3), of the synthesis of a cytosolic thyroid hormone binding protein (p58-M2) during liver regeneration, the synthesis of p58-M2 was evaluated. The synthesis of p58-M2 was measured by metabolic labeling of primary cultures derived from the re...

journal_title：Biochemical and biophysical research communications

authors： Obata T,Cheng SY

更新日期：1992-11-30 00:00:00

abstract：:Peptidylarginine deiminases (PADs) convert arginine residues in proteins into citrulline residues Ca(2+)-dependently. PAD V was recently found in granulocyte-differentiated HL-60 cells. To find a target of PAD V, we incubated HL-60 granulocytes with the calcium ionophore A23187 and studied deiminated proteins by immun...

journal_title：Biochemical and biophysical research communications

authors： Hagiwara T,Nakashima K,Hirano H,Senshu T,Yamada M

更新日期：2002-01-25 00:00:00

abstract：:This investigation of Ca2+ requirements for the mitogenic activation of lymphocytes by periodic acid has shown that oxidation by periodate causes an immediate and transient increase of Ca2+ influx and efflux in oxidized cells. Oxidized lymphocytes maintained in the medium containing 0.2 mM Ca2+ failed to proliferate o...

journal_title：Biochemical and biophysical research communications

authors： Hornicek FJ,Malinin GI,Malinin TI

更新日期：1992-02-28 00:00:00

abstract：:Recognition of oligodeoxynucleotides containing CpG motifs (CpG-ODNs) by toll-like receptor 9 (TLR9) inhibits RANKL-induced osteoclastogenesis from precursors. This inhibitory effect suggests the possibility of using this strategy to block pathological bone loss. However, the enhancing effect of CpG-ODNs on OC formati...

journal_title：Biochemical and biophysical research communications

authors： Chang JH,Chang EJ,Kim HH,Kim SK

更新日期：2009-11-06 00:00:00

abstract：:We have isolated and characterized the 5'-flanking region of the mouse RECK gene aiming to understand the mechanism of oncogene-mediated suppression of RECK gene expression. The upstream 52-base region was found to contain a promoter activity which is, to some extent, suppressed by the ras oncogene. This region contai...

journal_title：Biochemical and biophysical research communications

authors： Sasahara RM,Takahashi C,Noda M

更新日期：1999-11-02 00:00:00

abstract：:Metabolic deregulation accompanying type II diabetes is characterized by insulin resistance in peripheral tissues (liver, muscle, and adipose), mediated by impairments in insulin receptor (IR) signaling. Protein tyrosine phosphatase 1B (PTP1B) has been shown to be a negative regulator of IR autophosphorylation and thu...

journal_title：Biochemical and biophysical research communications

authors： Xu J,Li L,Qian Z,Hong J,Shen S,Huang W

更新日期：2005-04-08 00:00:00

abstract：:Incubation of isolated mitochondria in the presence of malonyl-CoA prevented proteolysis of the outer carnitine palmitoyltransferase by Nagarse and trypsin. Malonyl-CoA had no direct action on trypsin when present in a chromogenic assay system for proteolysis or when preincubated with the proteases in the absence of m...

journal_title：Biochemical and biophysical research communications

authors： Kashfi K,Cook GA

更新日期：1991-07-31 00:00:00