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Calcium is required for the mitogenic activation of lymphocytes by periodic acid oxidation.

Abstract：

:This investigation of Ca2+ requirements for the mitogenic activation of lymphocytes by periodic acid has shown that oxidation by periodate causes an immediate and transient increase of Ca2+ influx and efflux in oxidized cells. Oxidized lymphocytes maintained in the medium containing 0.2 mM Ca2+ failed to proliferate or to produce IL-2, whereas a 1.4 mM Ca2+ concentration was shown to be sufficient to sustain cellular proliferation and IL-2 secretion. These results indicate that mitogenic activation of lymphocytes by periodic acid oxidation is Ca(2+)-dependent.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Hornicek FJ,Malinin GI,Malinin TI

doi

10.1016/0006-291x(92)91620-6

subject

Has Abstract

pub_date

1992-02-28 00:00:00

pages

144-9

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(92)91620-6

journal_volume

183

pub_type

杂志文章

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