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Copper-metallothionein induction in the liver of LEC rats.

Abstract：

:Recently, copper (Cu) was found to be unusually accumulated, suggesting the induction of metallothionein (MT) in the liver of LEC rats (Long-Evans rats with a cinnamon-like coat color), which develop spontaneous jaundice with hereditary hepatitis. Thus, the direct relationship between the unusual Cu accumulation and the induction of Cu-MT was investigated by giving LEC rats Cu-overloaded or Cu-deficient diets. Results based on the determinations of Cu and MT levels in several organs, as well as the gel-filtration profiles of the cytosols of liver homogenates, showed that dietary Cu induced Cu-MT and development of hepatic injury associated with jaundice.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Sakurai H,Kamada H,Fukudome A,Kito M,Takeshima S,Kimura M,Otaki N,Nakajima K,Kawano K,Hagino T

doi

10.1016/0006-291x(92)91659-e

subject

Has Abstract

pub_date

1992-06-15 00:00:00

pages

548-52

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(92)91659-E

journal_volume

185

pub_type

杂志文章

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