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Reduced phosphorylcholine hydrolysis by homogenates of temporal regions of Alzheimer's brain.

Abstract：

:The hydrolysis of p-nitrophenylphosphorylcholine, p-nitrophenylphosphate, and phosphorylcholine was quantitated in homogenates prepared from the occipital and temporal regions of control and Alzheimer's Disease patient brain. There were no significant differences detected in activities of enzymes cleaving the first 2 compounds. A 78% reduction in the capacity for hydrolyzing phosphorylcholine by temporal homogenates from Alzheimer's patients compared to controls was demonstrated. The hydrolysis of this substrate by occipital homogenates was identical to control values. These results may explain the lack of cognitive improvement of Alzheimer's patients receiving dietary supplements of either choline or lecithin.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kanfer JN,McCartney DG

doi

10.1016/s0006-291x(86)80115-2

subject

Has Abstract

pub_date

1986-08-29 00:00:00

pages

315-9

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(86)80115-2

journal_volume

139

pub_type

杂志文章

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