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NF-Y and Sp1 are involved in transcriptional regulation of rat SND p102 gene.

Abstract：

:SND p102 is a rat liver endoplasmic reticulum cholesterol ester hydrolase recently described as a member of a conserved family of transcriptional coactivators that promotes phospholipid secretion into lipoproteins when overexpressed in hepatocytes. In this work, we report first evidence for a mechanism of transcriptional regulation for the SND p102 (Snd1) gene. Promoter activity of 5' deletion fragments determined in human HepG2 and rat McA-RH7777 hepatoma cells by luciferase reporter gene assays showed a minimal promoter involving two inverted CCAAT boxes. EMSA demonstrated specific binding of Sp1 to GC boxes in the proximal, highly active promoter region besides that of NF-Y to CCAAT boxes reported earlier. Site-directed disruption of such CCAAT and GC boxes led to reduction in transcriptional activity, confirming the functional implication of NF-Y and Sp1 in SND p102 gene transcription.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Rodríguez L,Ochoa B,Martínez MJ

doi

10.1016/j.bbrc.2007.02.110

subject

Has Abstract

pub_date

2007-04-27 00:00:00

pages

226-32

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(07)00418-4

journal_volume

356

pub_type

杂志文章

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