当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Haloperidol, a sigma receptor 1 antagonist, promotes ferroptosis in hepatocellular carcinoma cells.

Haloperidol, a sigma receptor 1 antagonist, promotes ferroptosis in hepatocellular carcinoma cells.

Abstract：

:Ferroptosis is a novel form of cell death, which is characterized by accumulation of reactive oxygen species (ROS). Sigma 1 receptor (S1R) has been suggested to function in oxidative stress metabolism. Both erastin and sorafenib significantly induced S1R protein expression. Haloperidol strongly promoted erastin- and sorafenib-induced cell death, which was blocked by ferrostatin-1 but not ZVAD-FMK or necrosulfonamide. During ferroptosis, haloperidol substantially increased the cellular levels of Fe2+, GSH and lipid peroxidation. Furthermore, several ferroptosis-related protein targets were up-regulated in the absence of haloperidol. Thus, Our study identified an association between haloperidol and ferroptosis for the first time. Our analyses of a combination of drugs may provide a novel strategy of hepatocellular carcinoma (HCC) therapy.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Bai T,Wang S,Zhao Y,Zhu R,Wang W,Sun Y

doi

10.1016/j.bbrc.2017.07.136

subject

Has Abstract

pub_date

2017-09-30 00:00:00

pages

919-925

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(17)31495-X

journal_volume

491

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Binding of anti-acetylcholine receptor antibodies inhibits the acetylcholine receptor mediated cation flux.

    abstract：:A fast kinetics, spectroscopic technique has been applied to the study of the transient cation flux associated to the binding of cholinergic agonist to native acetylcholine receptor (AcChR)-rich membrane vesicles in presence of anti-AcChR antibodies. The technique is based on the collisional quenching of an intravesic...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(84)91263-4

    authors： Gonzalez-Ros JM,Ferragut JA,Martinez-Carrion M

    更新日期：1984-04-30 00:00:00

  • Comparison of WNK4 and WNK1 kinase and inhibiting activities.

    abstract：:WNK kinases are novel serine/threonine protein kinases. Mutations in two members of the WNK family, WNK1 and WNK4, cause familial hyperkalemic hypertension. These kinases regulate ion transport across diverse epithelia; WNK4 reduces activity of the Na-Cl cotransporter activity and the potassium channel, ROMK, by reduc...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.03.132

    authors： Wang Z,Yang CL,Ellison DH

    更新日期：2004-05-07 00:00:00

  • Interaction of p59fyn with interferon-activated Jak kinases.

    abstract：:During IFN alpha stimulation, p59(fyn) associates with the Type I IFNR-associated Tyk-2 kinase in several human hematopoietic cell lines in vivo. This interaction is direct, and is mediated by the SH2 domain in p59(fyn), as shown by binding studies using glutathione-S-transferase fusion proteins and far western blots....

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.6741

    authors： Uddin S,Sher DA,Alsayed Y,Pons S,Colamonici OR,Fish EN,White MF,Platanias LC

    更新日期：1997-06-09 00:00:00

  • Functional expression of thyrotropin receptor in differentiated 3T3-L1 cells: a possible model cell line of extrathyroidal expression of thyrotropin receptor.

    abstract：:Thyrotropin receptor (TSHR) in extrathyroidal tissue, especially fat tissue, is supposed to have important roles in the development of extrathyroidal manifestations of Graves' disease. However, the molecular mechanism of TSHR expression is not known. Expression of TSHR mRNA and TSH-dependent cAMP production were obser...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.0868

    authors： Haraguchi K,Shimura H,Lin L,Saito T,Endo T,Onaya T

    更新日期：1996-06-05 00:00:00

  • Yeast adaptation to 2,4-dichlorophenoxyacetic acid involves increased membrane fatty acid saturation degree and decreased OLE1 transcription.

    abstract：:Yeast cells adapted to the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) exhibit a plasma membrane less susceptible to 2,4-D-induced disruption and are more tolerant than unadapted cells to lethal concentrations of the herbicide. These cells, adapted to grow in the presence of increasing concentrations of 2,4-D, we...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.02.158

    authors： Viegas CA,Cabral MG,Teixeira MC,Neumann G,Heipieper HJ,Sá-Correia I

    更新日期：2005-04-29 00:00:00

  • Special AT-rich sequence-binding protein 2 and its related genes play key roles in the differentiation of MC3T3-E1 osteoblast like cells.

    abstract：:Special AT-rich sequence-binding protein (SATB) plays a critical role in bone generation and osteoblast differentiation. In the present study, the differentially expressed genes by SATB2 overexpression were analyzed in MC3T3-E1 osteoblast-like cells using Alizarin red S staining, wound healing assay and Agilent's Huma...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.11.157

    authors： Kim IS,Jeong SJ,Kim SH,Jung JH,Park YG,Kim SH

    更新日期：2012-01-13 00:00:00

  • An induced pluripotent stem cell-mediated and integration-free factor VIII expression system.

    abstract：:Human artificial chromosome (HAC) has several advantages as a gene therapy vector, including stable episomal maintenance and the ability to carry large gene inserts. Induced pluripotent stem (iPS) cells also have a great potential for gene therapy, which can be generated from an individual's own tissues and contribute...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.12.096

    authors： Yakura Y,Ishihara C,Kurosaki H,Kazuki Y,Komatsu N,Okada Y,Doi T,Takeya H,Oshimura M

    更新日期：2013-02-08 00:00:00

  • Primary structure of the snake venom L-amino acid oxidase shows high homology with the mouse B cell interleukin 4-induced Fig1 protein.

    abstract：:The 2.8-kb sequence of cDNA encoding southeastern diamondback rattlesnake venom L-amino acid oxidase was determined. A translated single open reading frame revealed a 58.7-kDa polypeptide containing a signal sequence and FAD binding motif. The protein similarity search and analysis showed that the snake L-amino acid o...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.9024

    authors： Raibekas AA,Massey V

    更新日期：1998-07-30 00:00:00

  • The alpha 1-subunit of skeletal muscle L-type Ca channels is the key target for regulation by A-kinase and protein phosphatase-1C.

    abstract：:Despite the fact that the phosphorylation-mediated regulation of L-type Ca channels is viewed as a model of ion channel regulation, much remains to be learned about the protein phosphorylation and dephosphorylation reactions that underlie the regulation of the channels. The channel isoform most well studied biochemica...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.1024

    authors： Zhao XL,Gutierrez LM,Chang CF,Hosey MM

    更新日期：1994-01-14 00:00:00

  • A single replacement of histidine to arginine in EGFR-lytic hybrid peptide demonstrates the improved anticancer activity.

    abstract：:We previously reported that novel targeted "hybrid peptide" in which epidermal growth factor receptor (EGFR) binding peptide was conjugated with lytic-type peptide had selective cytotoxic activity to EGFR expressing cancer cell lines, and in vivo analysis revealed that this EGFR-lytic peptide displayed significant ant...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.03.030

    authors： Tada N,Horibe T,Haramoto M,Ohara K,Kohno M,Kawakami K

    更新日期：2011-04-08 00:00:00

  • Analysis of Ras-dependent signals that prevent caspase-3 activation and apoptosis induced by cytokine deprivation in hematopoietic cells.

    abstract：:In hematopoietic cells, Ras has been implicated in signaling pathways that prevent apoptosis triggered by deprivation of cytokines, such as interleukin-3 (IL-3). However, the mechanism whereby Ras suppresses cell death remains incompletely understood. We have investigated the role of Ras in IL-3 signal transduction by...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.1955

    authors： Terada K,Kaziro Y,Satoh T

    更新日期：2000-01-07 00:00:00

  • Delaying aging in Caenorhabditis elegans with protein aggregation inhibitors.

    abstract：:Recent evidence suggests that during aging there is widespread accumulation of aggregated insoluble proteins, even in the absence of pathological conditions. Pharmacological manipulation of protein aggregation might be helpful to unveil the involvement of protein aggregates during aging, as well as to develop novel st...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.10.143

    authors： Cuanalo-Contreras K,Park KW,Mukherjee A,Millán-Pérez Peña L,Soto C

    更新日期：2017-01-01 00:00:00

  • The expression of soluble and cell-bound alpha 2,6 sialyltransferase in human colonic carcinoma CaCo-2 cells correlates with the degree of enterocytic differentiation.

    abstract：:alpha 2,6 sialyltransferase towards the N-acetyllactosaminyl sequence (alpha 2,6 ST, E.C. 2.4.99.1) is one of the major sialyltransferases in human colonic cells; it strongly increases in human colorectal tumors and is largely expressed in fetal and neonatal rat colon. In this study we demonstrate that human colon car...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)80039-7

    authors： Dall'Olio F,Malagolini N,Serafini-Cessi F

    更新日期：1992-05-15 00:00:00

  • The number of accessible SH-groups in Escherichia coli membrane vesicles is increased by ATP or by formate.

    abstract：:The number of accessible SH-groups was determined in membrane vesicles prepared from Escherichia coli growing in fermentation conditions at slightly alkaline pH on glucose with or without added formate. Addition of ATP or formate to the vesicles caused a approximately 1.4-fold increase in the number of accessible SH-g...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(03)01460-8

    authors： Mnatsakanyan N,Poladian A,Bagramyan K,Trchounian A

    更新日期：2003-08-29 00:00:00

  • p70 S6 kinase is activated by sodium arsenite in adult rat cardiomyocytes: roles for phosphatidylinositol 3-kinase and p38 MAP kinase.

    abstract：:p70 S6 kinase (p70 S6k) is important in regulating a variety of cellular functions including mRNA translation and cell cycle progression and is activated by mitogens and hormones. Unexpectedly, we have found that, in adult rat cardiomyocytes, arsenite, which generally induces stress responses, markedly and rapidly act...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.7273

    authors： Wang X,Proud CG

    更新日期：1997-09-08 00:00:00

  • Identification of CGI-121, a novel PRPK (p53-related protein kinase)-binding protein.

    abstract：:PRPK (p53-related protein kinase) has been reported as a novel protein kinase which binds to the tumor suppressor protein p53 and induces phosphorylation of p53 at Ser 15. To identify novel binding partners of PRPK, we performed a yeast two-hybrid screening and isolated an expressed sequence tag CGI-121 by which a 20-...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(03)00333-4

    authors： Miyoshi A,Kito K,Aramoto T,Abe Y,Kobayashi N,Ueda N

    更新日期：2003-04-04 00:00:00

  • Bio-effectiveness of Tat-catalase conjugate: a potential tool for the identification of H2O2-dependent cellular signal transduction pathways.

    abstract：:Reactive oxygen species such as hydrogen peroxide (H(2)O(2)) have taken center stage as bona fide second messengers in various signaling pathways. Here, we report the synthesis, metabolic fate, and effectiveness in modulating such pathways of a Tat-catalase conjugate. Incubation of L2 cells with Tat-catalase greatly i...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(03)00335-8

    authors： Watanabe N,Iwamoto T,Bowen KD,Dickinson DA,Torres M,Forman HJ

    更新日期：2003-03-28 00:00:00

  • The N-terminal cleavage site of PrPSc from BSE differs from that of PrPSc from scrapie.

    abstract：:Heterogeneity in transmissible spongiform encephalopathy is thought to have derived from conformational variation in an abnormal isoform of the prion protein (PrPSc). To characterize PrPSc in bovine spongiform encephalopathy (BSE) and scrapie, we analyzed the newly generated N-terminus of PrPSc isoforms by digestion w...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.01.065

    authors： Hayashi HK,Yokoyama T,Takata M,Iwamaru Y,Imamura M,Ushiki YK,Shinagawa M

    更新日期：2005-03-25 00:00:00

  • The establishment of a novel high-throughput screening system using RNA-guided genome editing to identify chemicals that suppress aldosterone synthase expression.

    abstract：:Aldosterone is synthesized in the adrenal by the aldosterone synthase CYP11B2. Although the control of CYP11B2 expression is important to maintain the mineral homeostasis, its overexpression induced by the depolarization-induced calcium (Ca2+) signaling activation has been reported to increase the synthesis of aldoste...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.11.020

    authors： Ito R,Morita M,Nakano T,Sato I,Yokoyama A,Sugawara A

    更新日期：2021-01-01 00:00:00

  • A novel protein, MUDENG, induces cell death in cytotoxic T cells.

    abstract：:A screening system comprised of a randomized hybrid-ribozyme library has previously been used to identify pro-death genes in Fas-mediated apoptosis, and short sequence information of candidate genes from this system was previously reported by Kawasaki and Taira [H. Kawasaki, K. Taira, A functional gene discovery in th...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.03.139

    authors： Lee MR,Shin JN,Moon AR,Park SY,Hong G,Lee MJ,Yun CW,Seol DW,Piya S,Bae J,Oh JW,Kim TH

    更新日期：2008-06-06 00:00:00

  • Development of a single-cassette system for spatiotemporal gene regulation in mice.

    abstract：:The tetracycline-regulated gene expression system has been widely used in mice to turn a transgene on and off in a target organ, but with only limited success. We developed an advanced system in which a Tet-off regulation unit was integrated into the ROSA26 locus and became active after Cre-mediated excision of the ne...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.10.054

    authors： Miyazaki S,Miyazaki T,Tashiro F,Yamato E,Miyazaki J

    更新日期：2005-12-16 00:00:00

  • Marked rapid alterations in nocturnal pineal serotonin metabolism in mice and rats exposed to weak intermittent magnetic fields.

    abstract：:Adult AMES mice and male Sprague Dawley rats were exposed to an artificial magnetic field, generated by Helmholtz coils. 3.5 hours after the onset of darkness the coils were activated for one hour resulting in an inversion of the horizontal component of the earth's magnetic field. The coils were activated and deactiva...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)91439-y

    authors： Lerchl A,Nonaka KO,Stokkan KA,Reiter RJ

    更新日期：1990-05-31 00:00:00

  • Two new monoclonal antibodies against the alpha subunit of the human insulin-like growth factor-I receptor.

    abstract：:Recently, we have reported three monoclonal antibodies (mAbs) against purified human placental insulin-like growth factor (IGF)-I receptors. These antibodies, in contrast to the well-studied mAb alpha IR-3, stimulate binding of IGF-I and IGF-II to the receptor and DNA synthesis as well [Xiong, et al., Proc. Natl. Acad...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.2220

    authors： Li SL,Kato J,Paz IB,Kasuya J,Fujita-Yamaguchi Y

    更新日期：1993-10-15 00:00:00

  • Depletion of uracil-DNA glycosylase activity is associated with decreased cell proliferation.

    abstract：:Uracil-DNA glycosylase (UNG) is the primary enzyme responsible for removing uracil residues from DNA. Increasing evidence suggests that UNG may be a potential target for the development of novel antiviral and/or anticancer agents. To determine whether the uracil-DNA glycosylase inhibitor protein (UGI) could be used to...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.06.118

    authors： Studebaker AW,Ariza ME,Williams MV

    更新日期：2005-08-26 00:00:00

  • Immediate and neurotoxic effects of HIV protein gp120 act through CXCR4 receptor.

    abstract：:Primary rat hippocampal neurones show pronounced elevations of intracellular calcium within minutes of exposure to the HIV coat protein gp120. Culture of hippocampal neurones with gp120 causes significant neurotoxicity. We find that the peptide VSLSYRCPCRFF, a competitive inhibitor of the CXCR4 chemokine receptor, mar...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.3113

    authors： Pandey V,Bolsover SR

    更新日期：2000-07-21 00:00:00

  • Nitric oxide mediates interleukin-1-induced prostaglandin E2 production by vascular smooth muscle cells.

    abstract：:We examined the possible participation of nitric oxide (NO) in the activation of cyclooxygenase, a heme-containing enzyme, induced by interleukin-1 (IL-1) in vascular smooth muscle cells (VSMC). IL-1 induced a delayed and prolonged release of both NO and prostaglandin E2 (PGE2) from VSMC. NG-monomethyl-L-arginine (L-N...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.1836

    authors： Inoue T,Fukuo K,Morimoto S,Koh E,Ogihara T

    更新日期：1993-07-15 00:00:00

  • Expression and function of the atypical cadherin FAT1 in chronic liver disease.

    abstract：:Hepatic fibrosis can be considered as wound healing process in response to hepatocellular injury. Activation of hepatic stellate cells (HSCs) is a key event of hepatic fibrosis since activated HSCs are the cellular source of enhanced extracellular matrix deposition, and reversion of liver fibrosis is accompanied by cl...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.08.104

    authors： Valletta D,Czech B,Thasler WE,Müller M,Bosserhoff AK,Hellerbrand C

    更新日期：2012-09-28 00:00:00

  • MicroRNAs expression in ox-LDL treated HUVECs: MiR-365 modulates apoptosis and Bcl-2 expression.

    abstract：:Endothelial cells (ECs) apoptosis induced by oxidized low-density lipoprotein (ox-LDL) is thought to play a critical role in atherosclerosis. MicroRNAs (miRNAs) are a class of noncoding RNAs that posttranscriptionally regulate the expression of genes involved in diverse cell functions, including differentiation, growt...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.05.118

    authors： Qin B,Xiao B,Liang D,Xia J,Li Y,Yang H

    更新日期：2011-06-24 00:00:00

  • Proteomic analysis reveals a protective role for DJ-1 during 6-hydroxydopamine-induced cell death.

    abstract：:Loss-of-function mutations in the DJ-1/PARK7 gene are responsible for early-onset autosomal-recessive Parkinson's disease. DJ-1 is implicated in the protection of neurons from oxidative stress by scavenging hydrogen peroxide and regulating the transcriptional activity of multiple pathways. Here, we attempted to identi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.04.063

    authors： Kim SJ,Park YJ,Oh YJ

    更新日期：2012-05-25 00:00:00

  • Cyclic strain-induced endothelial MMP-2: role in vascular smooth muscle cell migration.

    abstract：:Matrix metalloproteinases (MMPs) play a vital role in vasculature response to hemodynamic stimuli via the degradation of extracellular matrix substrates. In this study, we investigated the putative role of cyclic strain-induced endothelial MMP-2 (and MMP-9) expression and release in modulating bovine aortic smooth mus...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.05.174

    authors： von Offenberg Sweeney N,Cummins PM,Birney YA,Redmond EM,Cahill PA

    更新日期：2004-07-23 00:00:00