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Delaying aging in Caenorhabditis elegans with protein aggregation inhibitors.

Abstract：

:Recent evidence suggests that during aging there is widespread accumulation of aggregated insoluble proteins, even in the absence of pathological conditions. Pharmacological manipulation of protein aggregation might be helpful to unveil the involvement of protein aggregates during aging, as well as to develop novel strategies to delay aging. Here we investigated the effect of known protein aggregation inhibitors on the lifespan and health-span of Caenorhabditis elegans. For this purpose, we selected various structurally diverse anti-aggregation compounds and screened them in liquid and solid medium for their ability to alter the rate of aging in vivo. Our results show that treatment of C. elegans with diverse aggregation inhibitors significantly increases the animal lifespan and health-span. These findings indicate that protein misfolding and aggregation may play an important role in cellular dysfunction during aging, opening a novel approach to increase longevity and enhance the quality of life during aging.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Cuanalo-Contreras K,Park KW,Mukherjee A,Millán-Pérez Peña L,Soto C

doi

10.1016/j.bbrc.2016.10.143

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

62-67

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(16)31839-3

journal_volume

482

pub_type

杂志文章

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