Epigenetic involvement of Alien/ESET complex in thyroid hormone-mediated repression of E2F1 gene expression and cell proliferation.

abstract：:Inflammation has multifaceted role in cancer progression including initiation, promotion and invasion by affecting the immune surveillance and associated signaling pathways. Inflammation facilitates the over-expression of cytokines, chemokines and growth factors involved in progression of different cancers including b...

journal_title：Biochemical and biophysical research communications

authors： Suman S,Sharma PK,Rai G,Mishra S,Arora D,Gupta P,Shukla Y

更新日期：2016-04-08 00:00:00

abstract：:A p60K protein in human colon adenocarcinoma tumor cell lines was identified as a myristoylated pp60c-src by fluorography and radioimmunoprecipitation analysis. Prevention of the myristoylation of pp60c-src was determined with N-fatty acyl glycinal compounds. Of the compounds tested, N-myristoyl glycinal diethylacetal...

journal_title：Biochemical and biophysical research communications

authors： Shoji S,Kurosawa T,Inoue H,Funakoshi T,Kubota Y

更新日期：1990-12-31 00:00:00

abstract：:This is the first study to demonstrate that the AT motif binding factor 1-A (ATBF1-A) is expressed in the crypts and the bases of villi of the small intestine and negatively regulates transcription of brush-border enzyme gene, aminopeptidase-N (APN). In situ hybridization visualized a limited ATBF1-A mRNA expression i...

journal_title：Biochemical and biophysical research communications

authors： Kataoka H,Joh T,Miura Y,Tamaoki T,Senoo K,Ohara H,Nomura T,Tada T,Asai K,Kato T,Itoh M

更新日期：2000-01-07 00:00:00

abstract：:Consumption of a single serving of tomatoes by healthy human volunteers was sufficient to alter levels of oxidative DNA base damage in white cell DNA within 24 h. Levels of the mutagenic oxidized purine base 8-hydroxyguanine decreased, especially in those subjects whose initial levels of this base were higher than the...

journal_title：Biochemical and biophysical research communications

authors： Rehman A,Bourne LC,Halliwell B,Rice-Evans CA

更新日期：1999-09-07 00:00:00

abstract：:The domain(s) responsible for the specific heterophilic adhesion between two members of the carcinoembryonic antigen (CEA) family, CEACAM6 and CEACAM8, both of which with three extracellular domains, were investigated using Chinese hamster ovary (CHO) transfectants expressing chimeric antigens. Using a chimeric antige...

journal_title：Biochemical and biophysical research communications

authors： Oikawa S,Sugiyama M,Kuroki M,Kuroki M,Nakazato H

更新日期：2000-11-30 00:00:00

abstract：:A dose-dependent increase in cholesterol absorption was induced by glucose addition (0-75 mM) to the apical medium of TC7 cells, a well-characterized clone of Caco-2. The uptake into the cells and the secretion rate to the basolateral space were both enhanced by glucose and galactose. This up-regulation was suppressed...

journal_title：Biochemical and biophysical research communications

authors： Play B,Salvini S,Haikal Z,Charbonnier M,Harbis A,Roussel M,Lairon D,Jourdheuil-Rahmani D

更新日期：2003-10-17 00:00:00

abstract：:The Cyclin D3 protein is a member of the D-type cyclins. Besides serving as cell cycle regulators, D-type cyclins have been reported to be able to interact with several transcription factors and modulate their transcriptional activations. Here we report that human activating transcription factor 5 (hATF5) is a new int...

journal_title：Biochemical and biophysical research communications

authors： Liu W,Sun M,Jiang J,Shen X,Sun Q,Liu W,Shen H,Gu J

更新日期：2004-09-03 00:00:00

abstract：:We located a novel binding site for grayanotoxin on the cytoplasmic linkers of voltage-dependent cardiac (rH1) or skeletal-muscle (mu 1) Na(+) channel isoforms (segments S4-S5 in domains D1 and D4), using the alanine scanning substitution method. GTX-modification of Na(+) channels, transiently expressed in HEK 293 cel...

journal_title：Biochemical and biophysical research communications

authors： Maejima H,Kinoshita E,Yuki T,Yakehiro M,Seyama I,Yamaoka K

更新日期：2002-07-12 00:00:00

abstract：:We investigated the expression of myocilin in the optic nerve head of porcine eyes by Western blotting and immunohistochemical staining. Myocilin was localized in the nucleus, centrosome, glial filament, mitochondria, and some parts of the cell membranes of the astrocytes. Myocilin was also detected at the edge-feet p...

journal_title：Biochemical and biophysical research communications

authors： Noda S,Mashima Y,Obazawa M,Kubota R,Oguchi Y,Kudoh J,Minoshima S,Shimizu N

更新日期：2000-10-05 00:00:00

abstract：:The long noncoding RNA Malat1 has been reported to be an oncogene that promotes tumor progress and correlates with prognosis in glioma. Growing evidence shows that autophagy plays a very important role in tumorigenesis and tumor cell survival, but whether Malat1 regulates autophagy in glioma is still unclear. In this ...

journal_title：Biochemical and biophysical research communications

authors： Fu Z,Luo W,Wang J,Peng T,Sun G,Shi J,Li Z,Zhang B

更新日期：2017-10-21 00:00:00

abstract：:Cellular Ca(2+) homeostasis is maintained through the integrated and coordinated function of Ca(2+) transport molecules, Ca(2+) buffers and sensors. These molecules are associated with the plasma membrane and different cellular compartments, such as the cytoplasm, nucleus, mitochondria, and cellular reticular network,...

journal_title：Biochemical and biophysical research communications

authors： Krebs J,Agellon LB,Michalak M

更新日期：2015-04-24 00:00:00

abstract：:Parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHrP) receptor expressed in rat cultured cortical type I astrocytes was identified and characterized. Northern blot analysis demonstrated that the PTH/PTHrP receptor mRNA is expressed in astrocytes. A human PTH fragment, PTH [1-34], stimulated adenylate c...

journal_title：Biochemical and biophysical research communications

authors： Hashimoto H,Aino H,Ogawa N,Nagata S,Baba A

更新日期：1994-04-29 00:00:00

abstract：:An amino acid substitution of Met for Val at position 30 of plasma prealbumin is known to be closely related to heredo-familial amyloidotic polyneuropathy(FAP). As a first step in development of a direct method for diagnosis of the disease, cDNA for normal human prealbumin was cloned and its nucleotide sequence was de...

journal_title：Biochemical and biophysical research communications

authors： Sasaki H,Sakaki Y,Matsuo H,Goto I,Kuroiwa Y,Sahashi I,Takahashi A,Shinoda T,Isobe T,Takagi Y

更新日期：1984-12-14 00:00:00

abstract：:Fourteen kb murine GLUT4 minigene (= -7395 GLUT4) contains DNA sequence that confers tissue specific, exercise-induced up-regulation of the GLUT4 gene in skeletal muscle and high-fat diet induced-down-regulation in white adipose tissue. To identify the DNA sequences required for regulated expression, we generated GLUT...

journal_title：Biochemical and biophysical research communications

authors： Tsunoda N,Cooke DW,Ikemoto S,Maruyama K,Takahashi M,Lane MD,Ezaki O

更新日期：1997-10-20 00:00:00

abstract：:The Monte Carlo method has been used to simulate the equilibrium properties of a planar array of 94 saturated lipid chains and one monomer of Gramicidin A. Chains are free to move laterally in the layer plane and to change conformation via gauche rotations and long axis rotations in a continuum. All non-hydrogen atoms...

journal_title：Biochemical and biophysical research communications

authors： Xing J,Scott HL

更新日期：1989-11-30 00:00:00

abstract：:Ceramide, the backbone of sphingolipids, has been reported to be involved in various cellular responses including apoptosis. We recently established and characterized a C2-ceramide-resistant HL-60 subline designated HL-CR. HL-CR cells were resistant to not only ceramide but also anti-cancer drugs including daunorubici...

journal_title：Biochemical and biophysical research communications

authors： Sawai H,Kawai S,Domae N

更新日期：2004-06-18 00:00:00

abstract：:MicroRNAs (miRNAs), small single-stranded regulatory RNAs capable of interfering with intracellular mRNAs that contain partial complementarity, are useful for the design of new therapies against cancer polymorphism and viral mutation. MiRNA was originally discovered in the intergenic regions of the Caenorhabditis eleg...

journal_title：Biochemical and biophysical research communications

authors： Ying SY,Lin SL

更新日期：2005-01-21 00:00:00

abstract：:Chloroquine (CQ) and amodiaquine (AQ) have been used for treating or preventing malaria for decades, and their application has expanded into treating inflammatory disease in humans. CQ and AQ are applicable for controlling rheumatoid arthritis, but their molecular mechanisms of anti-inflammatory activity remain to be ...

journal_title：Biochemical and biophysical research communications

authors： Oh S,Shin JH,Jang EJ,Won HY,Kim HK,Jeong MG,Kim KS,Hwang ES

更新日期：2016-05-27 00:00:00

abstract：:Hydrogen sulfide (H(2)S) is recognized as a physiologic mediator produced in a variety of tissues. It is produced by three enzymes, cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3MST). However, the regulation of H(2)S production by CSE has not well been understoo...

journal_title：Biochemical and biophysical research communications

authors： Mikami Y,Shibuya N,Ogasawara Y,Kimura H

更新日期：2013-02-08 00:00:00

abstract：:We investigated the influence of pregnancy on the expression of insulin-regulated glucose transporter (GLUT4) mRNA and protein in skeletal muscle and adipose tissue. GLUT4 mRNA expression in quadriceps muscle from control and pregnant rats was similar in the fasted and fed states. When the level of expression was dete...

journal_title：Biochemical and biophysical research communications

authors： Okuno S,Maeda Y,Yamaguchi Y,Takao Y,Trocino RA,Takino H,Kawasaki E,Yokota A,Uotani S,Akazawa S

更新日期：1993-03-15 00:00:00

abstract：:Influenza A viruses are a major threat to human health and inflict a significant public health challenge worldwide. Hemagglutinin (HA) is the main contributor to the infectivity of the virus and is a potential target for the development of antiviral therapeutic agents. The stem region of HA, which has been shown to be...

journal_title：Biochemical and biophysical research communications

authors： Yan L,Wang H,Sun L,Liu Y,Sun J,Zhao X,Li Y,Xie X,Hu J

更新日期：2019-10-15 00:00:00

abstract：:Although neuraminidase (NA) is the second major viral glycoprotein of influenza virus, its immune mechanism as a vaccine target has been less considered. Here we compared the properties of antibodies and the efficacy of cross protection by N1 and N2 NA proteins, inactivated split influenza vaccines (split), and tandem...

journal_title：Biochemical and biophysical research communications

authors： Kim YJ,Ko EJ,Kim MC,Lee YN,Kim KH,Jung YJ,Kang SM

更新日期：2017-11-04 00:00:00

abstract：:To identify novel psoriasis-associated genes, we focused on several ESTs (expressed sequence tags) whose expression was predominantly increased in the affected skin in patients with psoriasis vulgaris, as assessed by microarray assay. In this paper, a full-length cDNA corresponding to one of those ESTs (AI440266) was ...

journal_title：Biochemical and biophysical research communications

authors： Matsuzaka Y,Okamoto K,Tsuji H,Mabuchi T,Ozawa A,Tamiya G,Inoko H

更新日期：2002-10-11 00:00:00

abstract：:We describe the genomic organization and the functional promoter of the monocyte specific gene Dif-2, the human homologue to genes in mouse (gly96) and rat (PRG1), that is downregulated during cell differentiation. The Dif-2 gene consists of two exons and a single intron of 112 bp in length. RNase protection assay ind...

journal_title：Biochemical and biophysical research communications

authors： Pietzsch A,Büchler C,Schmitz G

更新日期：1998-04-28 00:00:00

abstract：:The molecular mechanisms by which chronic hypoxia, whether constant (CCH) or intermittent (CIH), alters the heart rhythm are still under debate. Expression level, control, maturational profile and intercoordination of 54 genes encoding heart rhythm determinants (HRDs) were analyzed in 36 mice subjected for 1, 2 or 4 w...

journal_title：Biochemical and biophysical research communications

authors： Iacobas DA,Iacobas S,Haddad GG

更新日期：2010-01-22 00:00:00

abstract：:Hypoxic preconditioning is a well-known strategy to improve the survival and therapeutic potential of stem cells against various challenges including hemodynamic and neurohormonal modulations. However, the mechanism involved in hypoxia-induced benefits on stem cells is still ambiguous. In pathological hypertension, th...

journal_title：Biochemical and biophysical research communications

authors： Lai CH,Barik P,Hsieh DJ,Day CH,Ho TJ,Chen RJ,Kuo WW,Padma VV,Shibu MA,Huang CY

更新日期：2020-11-12 00:00:00

abstract：:Estrogens play an important role in the regulation of longitudinal bone growth in man, as demonstrated by recent descriptions of individuals with estrogen insensitivity or aromatase deficiency. Two estrogen receptors, ERalpha and ERbeta, have been cloned. The aim of the present study was to investigate the function of...

journal_title：Biochemical and biophysical research communications

authors： Vidal O,Lindberg M,Sävendahl L,Lubahn DB,Ritzen EM,Gustafsson JA,Ohlsson C

更新日期：1999-11-19 00:00:00

abstract：:Activation of seven-transmembrane G-protein coupled receptor (GPCR) mediates extracellular signals into intracellular responses. G-protein coupled receptor 55 (GPR55) is one of GPCRs and activated by endogenous cannabinoids. A family of regulators of G-protein signaling (RGS) stimulates GTP hydrolysis of alpha subunit...

journal_title：Biochemical and biophysical research communications

authors： Jang H,Kim Y,Ghil S

更新日期：2020-12-17 00:00:00

abstract：:We investigated the presence of the carbohydrate ligand for E-selectin on the cell surface of rat polymorphonuclear leukocytes (PMN). Rat PMN, isolated from peripheral blood, adhered to recombinant rat E-selectin-coated microplates. The adhesion was inhibited either by an anti-rat E-selectin monoclonal antibody (MAb),...

journal_title：Biochemical and biophysical research communications

authors： Misugi E,Kawamura N,Imanishi N,Tojo SJ,Morooka S

更新日期：1995-10-13 00:00:00

abstract：:Urokinase plasminogen activator (uPA) and its receptor uPAR play a major role in immune cell-mediated, including natural killer (NK) cell-mediated, degradation of extracellular matrices. Herein, we investigate the effects of IL-2 on NK cell uPA and uPAR. RNA and protein analyses showed upregulation of uPA and uPAR fol...

journal_title：Biochemical and biophysical research communications

authors： Al-Atrash G,Shetty S,Idell S,Xue Y,Kitson RP,Halady PK,Goldfarb RH

更新日期：2002-03-22 00:00:00