Hydrogen sulfide is produced by cystathionine γ-lyase at the steady-state low intracellular Ca(2+) concentrations.

Abstract:

:Hydrogen sulfide (H(2)S) is recognized as a physiologic mediator produced in a variety of tissues. It is produced by three enzymes, cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3MST). However, the regulation of H(2)S production by CSE has not well been understood. Here we show that H(2)S producing activity of CSE is regulated by intracellular Ca(2+) concentrations. In the presence of pyridoxal 5'-phosphate (PLP) CSE efficiently produces H(2)S at the steady-state low Ca(2+) concentrations but is suppressed at high Ca(2+) concentrations. In the absence of PLP H(2)S production maintains the suppressed levels at high Ca(2+) concentrations and decreased further at low Ca(2+) concentrations. These observations suggest that CSE produces H(2)S at the steady-state in cells and that the production is suppressed when the intracellular Ca(2+) concentrations are increased.

authors

Mikami Y,Shibuya N,Ogasawara Y,Kimura H

doi

10.1016/j.bbrc.2013.01.010

subject

Has Abstract

pub_date

2013-02-08 00:00:00

pages

131-5

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(13)00046-6

journal_volume

431

pub_type

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