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Ca(2+) homeostasis and endoplasmic reticulum (ER) stress: An integrated view of calcium signaling.

Abstract：

:Cellular Ca(2+) homeostasis is maintained through the integrated and coordinated function of Ca(2+) transport molecules, Ca(2+) buffers and sensors. These molecules are associated with the plasma membrane and different cellular compartments, such as the cytoplasm, nucleus, mitochondria, and cellular reticular network, including the endoplasmic reticulum (ER) to control free and bound Ca(2+) levels in all parts of the cell. Loss of nutrients/energy leads to the loss of cellular homeostasis and disruption of Ca(2+) signaling in both the reticular network and cytoplasmic compartments. As an integral part of cellular physiology and pathology, this leads to activation of ER stress coping responses, such as the unfolded protein response (UPR), and mobilization of pathways to regain ER homeostasis.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Krebs J,Agellon LB,Michalak M

doi

10.1016/j.bbrc.2015.02.004

subject

Has Abstract

pub_date

2015-04-24 00:00:00

pages

114-21

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(15)00211-9

journal_volume

460

pub_type

杂志文章,评审

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