Inhibition of initiation of simian virus 40 chromosome synthesis by dihydroxyanthraquinone.

Abstract:

:The mode of action of dihydroxyanthraquinone, a new antitumor drug, on eucaryotic chromosome structure and function was investigated using simian virus 40 as a model system. Dihydroxyanthraquinone specifically inhibited initiation of viral replicons. Little or no viral DNA synthesis was recovered in cells after the removal of the drug. Elongation and termination of DNA already initiated could proceed continuously to completion in drug-treated cells. The drug appeared to be stably associated with viral chromosomes in cells. The irreversible inhibition of replicon initiation might contribute to its anti-proliferative and anti-neoplastic activity.

authors

Su RT,Ma XJ,Cheng CC

doi

10.1016/0006-291x(85)90409-7

subject

Has Abstract

pub_date

1985-07-16 00:00:00

pages

249-56

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(85)90409-7

journal_volume

130

pub_type

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