HeLa cells contain the atrial natriuretic peptide receptor with guanylate cyclase activity.

Abstract:

:Receptors for atrial natriuretic peptide (ANP) are heterogeneous: an approximately 140-kDa receptor exhibits ANP-stimulated guanylate cyclase activity whereas an approximately 65-kDa receptor is thought to act only as a clearance-storage protein. We have used photoaffinity labeling techniques to show that the human cell line, HeLa, contains predominantly the approximately 140-kDa ANP receptor. In contrast, several other cell lines contain primarily the approximately 65-kDa receptor. In HeLa cells, ANP bound specifically to high affinity binding sites (Kd approximately 2 nM) and stimulated a rapid, dose-dependent accumulation of cGMP. These cell lines can thus provide useful models to study the multiple mechanisms of ANP action.

authors

Watt VM,Yip CC

doi

10.1016/0006-291x(89)91512-x

subject

Has Abstract

pub_date

1989-10-31 00:00:00

pages

671-7

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(89)91512-X

journal_volume

164

pub_type

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