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Nucleotide sequence of a bovine lens alpha A-crystallin cDNA.

Abstract：

:We have determined the nucleotide sequence of a bovine lens alpha A2-crystallin cDNA clone, designated pBL alpha A2-1. The 793 bp cDNA insert contains coding information for the entire 173 amino acid alpha A2-crystallin polypeptide, as well as non-translated sequences located both upstream and downstream from the coding region. The coding sequences contained in pBL alpha A2-1 are at least 89% homologous with the corresponding sequences from other mammalian alpha A-crystallin genes, and are 78% homologous to the frog alpha A-crystallin coding region. In contrast, the downstream nontranslated sequences of the mammalian alpha A-crystallin transcripts show much greater sequence divergence, with the bovine sequences averaging 47% homology with the corresponding sequences from other mammalian species.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Hay RE,Petrash JM

doi

10.1016/0006-291x(87)91072-2

subject

Has Abstract

pub_date

1987-10-14 00:00:00

pages

31-7

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(87)91072-2

journal_volume

148

pub_type

杂志文章

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