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Anticancer activity of arborinine from Glycosmis parva leaf extract in human cervical cancer cells.

Abstract：

:Glycosmis parva is a small shrub found in Thailand. Ethyl acetate (EtOAc) extract from its leaves has been shown to exert anticancer effects in vitro; however, the compound responsible for this activity has not been isolated and characterized. In this study, we demonstrate that arborinine, a major acridone alkaloid in the EtOAc fraction, decreased proliferation and was strongly cytotoxic to HeLa cervical cancer cells without significantly affecting normal cells. The compound also inhibited tumor spheroid growth much more potently than chemotherapeutic drugs bleomycin, gemcitabine, and cisplatin. In addition, unlike cisplatin, arborinine activated caspase-dependent apoptosis without inducing DNA damage response. We further show that arborinine strongly suppressed cancer cell migration by downregulating expression of key regulators of epithelial-mesenchymal transition. Taken together, our data provide important insights into the molecular mechanism of arborinine's anticancer activity, supporting its potential use for treating cervical cancer.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Piboonprai K,Khumkhrong P,Khongkow M,Yata T,Ruangrungsi N,Chansriniyom C,Iempridee T

doi

10.1016/j.bbrc.2018.04.175

subject

Has Abstract

pub_date

2018-06-12 00:00:00

pages

866-872

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(18)30968-9

journal_volume

500

pub_type

杂志文章

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