Trypanosoma cruzi: TcRAB7 protein is localized at the Golgi apparatus in epimastigotes.

Abstract:

:In mammalian cells, the Rab7 protein is a key element of late endocytic membrane traffic. Several results suggest that it is involved in the transport from early to late endosome or from late endosome to lysosome. We have previously characterized a Rab7 gene homologue (TcRAB7) in Trypanosoma cruzi. Now, using an affinity-purified antibody specific to TcRAB7 protein we have determined that it is localized at the Golgi apparatus of the parasite. Our results indicate that the T. cruzi Rab7 homologue may function in a different route than its counterparts in mammalian cells.

authors

Araripe JR,Cunha e Silva NL,Leal ST,de Souza W,Rondinelli E

doi

10.1016/j.bbrc.2004.06.159

subject

Has Abstract

pub_date

2004-08-20 00:00:00

pages

397-402

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(04)01371-3

journal_volume

321

pub_type

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