Abstract:
:The isolation and sequence analysis of the gene encoding the bovine atrial natriuretic peptide (ANP) precursor is described. The bovine-ANP coding sequences are located on three exons which are interrupted by two intervening sequences. Comparison of the bovine, human, rat and mouse ANP gene sequences reveals a common organization of introns and exons and a high degree of sequence homology in the 5'-flanking and coding regions. Examination of the pre-proANP amino acid sequence derived from the bovine gene with those from rat, mouse and human, indicates a high degree of sequence homology in both the amino-terminal and biologically-active carboxy-terminal ANP region. The latter region in the bovine sequence resembles its human counterpart except for a carboxy-terminal Arg-Arg dipeptide.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Vlasuk GP,Miller J,Bencen GH,Lewicki JAdoi
10.1016/0006-291x(86)90924-1subject
Has Abstractpub_date
1986-04-14 00:00:00pages
396-403issue
1eissn
0006-291Xissn
1090-2104pii
0006-291X(86)90924-1journal_volume
136pub_type
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