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Identification and characterization of receptors for tumor necrosis factor-alpha in the brain.

Abstract：

:Specific receptors for murine TNF have been identified in homogenates of rodent brain. These receptors are saturable and bind TNF with sufficient affinity to ensure occupancy by cytokine elaborated during infection. 125I-mTNF was detected in four specific complexes of Mr 130,000, 90,000, 66,000 and 60,000 after affinity labeling. Solubilization of brain membranes into detergent increased binding capacity 4-fold which indicates the presence of latent receptors for mTNF in the brain. Specific binding was greatest in the brainstem, least in the cerebellum and was also detected in the cortex, thalamus and basal ganglia.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kinouchi K,Brown G,Pasternak G,Donner DB

doi

10.1016/0006-291x(91)92113-x

subject

Has Abstract

pub_date

1991-12-31 00:00:00

pages

1532-8

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(91)92113-X

journal_volume

181

pub_type

杂志文章

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