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Secretion of N-terminal domain of α-dystroglycan in cerebrospinal fluid.

Abstract：

:α-Dystroglycan (α-DG) plays crucial roles in maintaining the stability of cells. We demonstrated previously that the N-terminal domain of α-DG (α-DG-N) is secreted by cultured cells into the culture medium. In the present study, to clarify its function in vivo, we generated a monoclonal antibody against α-DG-N and investigated the secretion of α-DG-N in human cerebrospinal fluid (CSF). Interestingly, we found that a considerable amount of α-DG-N was present in CSF. α-DG-N in CSF was a sialylated glycoprotein with both N- and O-linked glycan. These observations suggest that secreted α-DG-N may be transported via CSF and have yet unidentified effects on the nervous system.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Saito F,Saito-Arai Y,Nakamura-Okuma A,Ikeda M,Hagiwara H,Masaki T,Shimizu T,Matsumura K

doi

10.1016/j.bbrc.2011.06.150

subject

Has Abstract

pub_date

2011-07-29 00:00:00

pages

365-9

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(11)01149-1

journal_volume

411

pub_type

杂志文章

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