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Photo-released intracellular Ca2+ evokes reversible mechanical responses in supporting cells of the guinea-pig organ of Corti.

Abstract：

:Loaded under whole cell patch-clamp configuration, the caged Ca2+ molecule DM-nitrophen was used to increase [Ca2+]i rapidly and reversibly in isolated Deiters cells of the organ of Corti. Photolysis of DM-nitrophen increased [Ca2+]i from resting concentrations of 20-50 nM to values above microM, as measured with the fluorescent indicator Fluo-3. Immediately after the photoliberation of Ca2+, a movement of the head of the phalangeal process could be observed in 75% of cells (n = 28). This mechanical movement, with an amplitude ranging between 0.5 to 1 micron within few hundred of ms, consisted of an extension of the phalanges away from the cell body. Measurement of phalangeal stiffness in transversal flexion toward the cell body ranged between 15-440 pN/micron. Stiffness can increase by 28 to 51% after rising [Ca2+]i. The results suggest Ca2+ as a potential intracellular messenger for active mechanical responses in Deiters cells.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Dulon D,Blanchet C,Laffon E

doi

10.1006/bbrc.1994.1841

subject

Has Abstract

pub_date

1994-06-30 00:00:00

pages

1263-9

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(84)71841-9

journal_volume

201

pub_type

杂志文章

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