Xenopus Suppressor of Hairless 2 is involved in the cell fate decision during gastrulation through the transcriptional regulation of Xoct25/91.

abstract：:The role of PPARs in the regulation of human adipose tissue secretome has received little attention despite its potential importance in the therapeutic actions of PPAR agonists. Here, we have investigated the effect of selective PPARgamma, PPARalpha, and PPARbeta/delta agonists on the production of adipokines by human...

journal_title：Biochemical and biophysical research communications

authors： Klimcakova E,Moro C,Mazzucotelli A,Lolmède K,Viguerie N,Galitzky J,Stich V,Langin D

更新日期：2007-07-06 00:00:00

abstract：:AMP, an allosteric inhibitor at neutral pH, activates snakes muscle fructose 1,6-bisphosphatase at pH 9.2. The activation is virtually unique for the snake muscle enzyme: activation was not observed for the enzymes from either human and rabbit liver or porcine kidney. The activation is Mg(2+)-dependent but was not obs...

journal_title：Biochemical and biophysical research communications

authors： Zhao FK,Xu SQ,Xu GJ

更新日期：1998-03-27 00:00:00

abstract：:We found that PSK has an antiviral effect on human immunodeficiency virus (HIV) in vitro. One of the mechanisms of this effect is attributable to the inhibition of binding of HIV with lymphocytes. Here, we found that PSK inhibits reverse transcriptase in a non-competitive way in vitro. Such inhibition may be important...

journal_title：Biochemical and biophysical research communications

authors： Hirose K,Hakozaki M,Kakuchi J,Matsunaga K,Yoshikumi C,Takahashi M,Tochikura TS,Yamamoto N

更新日期：1987-12-16 00:00:00

abstract：:P53 is renowned as a cellular tumor suppressor poised to instigate remedial responses to various stress insults that threaten DNA integrity. P53 levels and activities are kept under tight regulation involving a complex network of activators and inhibitors, which determine the type and extent of p53 growth inhibitory s...

journal_title：Biochemical and biophysical research communications

authors： Levav-Cohen Y,Goldberg Z,Zuckerman V,Grossman T,Haupt S,Haupt Y

更新日期：2005-06-10 00:00:00

abstract：:RAP80, a member of the BRCA1-A complex, is a well-known crucial regulator of cell cycle checkpoint and DNA damage repair in the nucleus. However, it is still unclear whether Rap80 localizes to another region outside the nucleus and plays different roles with its partners. Here, we found mitochondrial p32 as a novel bi...

journal_title：Biochemical and biophysical research communications

authors： Chung HJ,Korm S,Lee SI,Phorl S,Noh S,Han M,Naskar R,Kim H,Lee JY

更新日期：2017-10-21 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) brings about a wide spectrum of toxic and biochemical changes, most of which are mediated by the AH receptor (AHR). Recent cloning of the AHR from the two most TCDD-resistant laboratory animals, Han/Wistar (Kuopio) rats and hamsters, suggested a critical role for the C-termin...

journal_title：Biochemical and biophysical research communications

authors： Korkalainen M,Tuomisto J,Pohjanvirta R

更新日期：2001-08-03 00:00:00

abstract：:The crude extracts from Sphingomonas paucimobilus containing 2-hydroxy fatty acid-rich sphingolipids were found to oxidize [1-14C]-myristate to 2-hydroxymyristate in the presence of NADH. The myristate-oxidation activity was partially purified about 290-fold from the cell-free extracts by ammonium sulfate fractionatio...

journal_title：Biochemical and biophysical research communications

authors： Matsunaga I,Kusunose E,Yano I,Ichihara K

更新日期：1994-06-30 00:00:00

abstract：:Increased microvessel density in atherosclerotic plaques plays a major role in promoting plaque destabilization resulting in increased risk of stroke and myocardial infarction. Previously we have shown that expression of the inflammatory cytokine, Oncostatin-M (OSM), in human atherosclerotic plaques correlated with in...

journal_title：Biochemical and biophysical research communications

authors： Albasanz-Puig A,Murray J,Namekata M,Wijelath ES

更新日期：2012-11-09 00:00:00

abstract：:Photoreceptor-specific gene expression is controlled by a hierarchical network of transcription factors, including the master regulators cone-rod homeobox (Crx) and neural retina leucine zipper (Nrl). Myocyte-enhancer factor 2c (Mef2c) is an ubiquitously expressed transcription factor with important functions in the c...

journal_title：Biochemical and biophysical research communications

authors： Wolf A,Aslanidis A,Langmann T

更新日期：2017-01-29 00:00:00

abstract：:Recombinant human insulin-like growth factor binding protein 3 (hIGFBP-3) stably expressed in chinese hamster ovary cells (CHO cells) has been purified to homogeneity from serum-free culture media. The purified protein migrates as a doublet (45/43 kDa) upon SDS-PAGE. The purified recombinant hIGFBP-3 is fully active a...

journal_title：Biochemical and biophysical research communications

authors： Tressel TJ,Tatsuno GP,Spratt K,Sommer A

更新日期：1991-07-31 00:00:00

abstract：:Mitogen-activated protein kinases (MPKs) are involved in a number of signaling pathways that control plant development and stress tolerance via the phosphorylation of target molecules. However, so far only a limited number of target molecules have been identified. Here, we provide evidence that MYB41 represents a new ...

journal_title：Biochemical and biophysical research communications

authors： Hoang MH,Nguyen XC,Lee K,Kwon YS,Pham HT,Park HC,Yun DJ,Lim CO,Chung WS

更新日期：2012-05-25 00:00:00

abstract：:Members of the armadillo (arm) repeat family of proteins are implicated in tumorigenesis, embryonic development, and maintenance of tissue integrity. We have cloned cDNA for a novel human arm repeat protein, ALEX1, encoding 453 amino acids. ALEX1 shares significant homology with uncharacterized ORF KIAA0512 and putati...

journal_title：Biochemical and biophysical research communications

authors： Kurochkin IV,Yonemitsu N,Funahashi SI,Nomura H

更新日期：2001-01-12 00:00:00

abstract：:Hepatocyte growth factor/scatter factor (HGF) is a multifunctional growth factor that is linked to the initiation and/or progression of numerous malignancies. HGF also alters cancer cell responses to DNA damaging cytotoxic agents. Many cell responses to Met activation require alterations in metabolic activity but how ...

journal_title：Biochemical and biophysical research communications

authors： Xia S,Laterra J

更新日期：2006-07-14 00:00:00

abstract：:We purified the transcription antitermination complex of phi 80 (phi 80-pN complex). This complex had a molecular weight of approx. 42,000, and the subunits of this complex could be separated by SDS polyacrylamide gel electrophoresis. The complex was composed of two different polypeptides, one was the phi 80 N gene pr...

journal_title：Biochemical and biophysical research communications

authors： Kanemoto K,Miyashita T,Matsushiro A

更新日期：1990-05-16 00:00:00

abstract：:Gangliosides are implicated in neuronal development processes. The regulation of ganglioside levels is closely related to the induction of neuronal cell differentiation. In this study, the relationship between ganglioside expression and neuronal cell development was investigated using an in vitro model of neural diffe...

journal_title：Biochemical and biophysical research communications

authors： Lee DH,Koo DB,Ko K,Ko K,Kim SM,Jung JU,Ryu JS,Jin JW,Yang HJ,Do SI,Jung KY,Choo YK

更新日期：2007-10-19 00:00:00

abstract：:While there have been many single-molecule studies of kinesin-1, most have been done along microtubules purified from bovine or porcine brain, and relatively little is known about how variations in tubulin might alter motor function. Of particular interest is transport along microtubules polymerized from tubulin purif...

journal_title：Biochemical and biophysical research communications

authors： Feizabadi MS,Jun Y

更新日期：2014-11-28 00:00:00

abstract：:The sequence of a novel cGMP-regulated, tetrameric, K(+) selective channel (Sp-tetraKCNG) was discovered in the sea urchin Strongylocentrotus purpuratus. The Sp-tetraKCNG is a single polypeptide made of four KCNG domains similar to voltage-dependent Na(+) and Ca(2+) channels. Each KCNG domain has six transmembrane seg...

journal_title：Biochemical and biophysical research communications

authors： Galindo BE,de la Vega-Beltrán JL,Labarca P,Vacquier VD,Darszon A

更新日期：2007-03-16 00:00:00

abstract：:The polyketide synthases found in a variety of plants and fungi provide a varied source of biologically active compounds of pharmacological and medicinal interest. Stilbene synthase and chalcone synthase catalyze the formation of a common tetraketide intermediate, but use different cyclization mechanisms to produce di...

journal_title：Biochemical and biophysical research communications

authors： Healy EF,Cervantes L,Nabona B,Williams J

更新日期：2018-03-18 00:00:00

abstract：:The association of endogenous synenkephalin and met-enkephalin containing peptides with the membrane of bovine chromaffin granules and physicochemical characteristics of this association were studied. The associated materials were only released at a non physiological pH range and this effect was enhanced with growing ...

journal_title：Biochemical and biophysical research communications

authors： Ase A,Vindrola O,Aloyz R,Inés M,Vida R,Finkielman S,Nahmod V

更新日期：1989-02-15 00:00:00

abstract：BACKGROUND:Lipopolysaccharide (LPS)-induced macrophage/monocyte activation and pro-inflammatory cytokines production are important mediators for periodontitis progression. The current study tested the potential role of insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in the process. METHODS:THP-1 human ma...

journal_title：Biochemical and biophysical research communications

authors： Xie J,Li Q,Zhu XH,Gao Y,Zhao WH

更新日期：2019-06-11 00:00:00

abstract：:Glial cells have been shown to induce enzyme activities, which are characteristically high in brain capillaries, in cerebral and non cerebral endothelial cells in culture. We evaluated the activity of gamma-glutamyl transpeptidase (gamma GT) in freshly isolated (ex vivo) bovine blood (BEC) and lymphatic (LEC) endothel...

journal_title：Biochemical and biophysical research communications

authors： Weber E,Lorenzoni P,Raffaelli N,Cavina N,Sacchi G

更新日期：1996-08-23 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPAR-gamma) decreases the growth of certain cancer cells. In the present study, we found that six different human pancreatic cancer cell lines (AsPC-1, BxPC-3, Capan-2, HPAF-II, MIA PaCa-2, and PANC-1) expressed PPAR-gamma m-RNA and synthesized the protein. The endogen...

journal_title：Biochemical and biophysical research communications

authors： Eibl G,Wente MN,Reber HA,Hines OJ

更新日期：2001-09-21 00:00:00

abstract：:Neurogenin-3 (ngn-3) expression is critical for endocrine development in the developing pancreas. We found that when ngn-3 was inhibited in an E11.5 pancreas, using either morpholino antisense or siRNA, it led to a significant decrease in endocrine differentiation after seven days in culture. Endocrine differentiation...

journal_title：Biochemical and biophysical research communications

authors： Prasadan K,Tulachan S,Guo P,Shiota C,Shah S,Gittes G

更新日期：2010-06-11 00:00:00

abstract：:IGF-I, when added to TSH-primed FRTL-5 cells, induces a long lasting Ca2+ influx and then DNA synthesis. Ca2+ channel agonist, BAYK 8644, is capable to mimic these effects on cell proliferation. We studied the effect of genistein, a specific tyrosine kinase inhibitor, on BAY K8644- or IGF-I- induced cell cycle progres...

journal_title：Biochemical and biophysical research communications

authors： Takano T,Takada K,Tada H,Nishiyama S,Amino N

更新日期：1993-02-15 00:00:00

abstract：:We examined the adrenocorticotropic hormone-releasing activities of several human interleukin-1 beta analogues that have markedly reduced pyrogenic activities in rats. Among the analogues tested, [Gly4]-, [Leu93]- and [1-148]-interleukin-1 beta increased the plasma adrenocorticotropic hormone level to almost that indu...

journal_title：Biochemical and biophysical research communications

authors： Naito Y,Fukata J,Masui Y,Hirai Y,Murakami N,Tominaga T,Nakai Y,Tamai S,Mori K,Imura H

更新日期：1990-02-28 00:00:00

abstract：:Lipoteichoic acid is a major cell wall virulence factor of gram-positive bacteria. LTAs from various bacteria have differential immunostimulatory potentials due to heterogeneity in their structures. Although recent studies have demonstrated that LTA isolated from Lactobacillus plantarum (pLTA) has anti-inflammatory pr...

journal_title：Biochemical and biophysical research communications

authors： Jang KS,Baik JE,Han SH,Chung DK,Kim BG

更新日期：2011-04-22 00:00:00

abstract：:To investigate the involvement of thyroid hormone on the release of atrial natriuretic polypeptide (ANP), we have measured immunoreactive ANP in the atria and plasma of experimental hyperthyroid and hypothyroid rats. Plasma ANP was higher (p less than 0.05) in hyperthyroid rats and was lower (p less than 0.05) in hypo...

journal_title：Biochemical and biophysical research communications

authors： Kohno M,Takaori K,Matsuura T,Murakawa K,Kanayama Y,Takeda T

更新日期：1986-01-14 00:00:00

abstract：:The aim of the present study was to identify a high affinity InsP4 receptor in membranes from cerebellum or brain from several species. In samples obtained from sheep, beef, human and rat, a 42 kDa protein represents an Ins(1,3,4,5)P4 receptor, similar to the InsP4 receptor from pig cerebellum, which we have described...

journal_title：Biochemical and biophysical research communications

authors： Reiser G,Kunzelmann U,Hülser E,Stricker R,Hoppe J,Lottspeich F,Kalbacher H

更新日期：1995-09-05 00:00:00

abstract：:Down syndrome (DS) leads to cardiac defects which are common and significant in babies with DS. We recently generated chimeric mice carrying a human chromosome (hChr) 21. The contribution ratio of embryonic stem (ES) cells containing a hChr 21 was specifically low in the heart, compared to other organs, and cardiovasc...

journal_title：Biochemical and biophysical research communications

authors： Inoue T,Shinohara T,Takehara S,Inoue J,Kamino H,Kugoh H,Oshimura M

更新日期：2000-06-24 00:00:00

abstract：:Studies have shown that High mobility group A2 (HMGA2), a non-histone protein, can promote epithelial-mesenchymal transition (EMT), which plays a critical role in prostate cancer progression and metastasis. Interestingly, full-length or wild-type HMGA2 and truncated (lacking the 3'UTR) HMGA2 isoforms are overexpressed...

journal_title：Biochemical and biophysical research communications

authors： Hawsawi O,Henderson V,Burton LJ,Dougan J,Nagappan P,Odero-Marah V

更新日期：2018-09-26 00:00:00