A biological response modifier, PSK, inhibits reverse transcriptase in vitro.

Abstract:

:We found that PSK has an antiviral effect on human immunodeficiency virus (HIV) in vitro. One of the mechanisms of this effect is attributable to the inhibition of binding of HIV with lymphocytes. Here, we found that PSK inhibits reverse transcriptase in a non-competitive way in vitro. Such inhibition may be important in its anti-HIV effect as well as its inhibitory effect on the binding of HIV with lymphocytes.

authors

Hirose K,Hakozaki M,Kakuchi J,Matsunaga K,Yoshikumi C,Takahashi M,Tochikura TS,Yamamoto N

doi

10.1016/0006-291x(87)90404-9

subject

Has Abstract

pub_date

1987-12-16 00:00:00

pages

562-7

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(87)90404-9

journal_volume

149

pub_type

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