IGF2BP1 promotes LPS-induced NFκB activation and pro-inflammatory cytokines production in human macrophages and monocytes.

abstract：:Investigations of the coenzyme specificity of N5-methyltetrahydrofolate-homocysteine methyltransferases of diverse biological origin revealed previously unrecognized differences between Escherichia coli methyltransferase and the corresponding enzymes of other species. Cyanocobalamin (CNCbl) actively supports methyltra...

journal_title：Biochemical and biophysical research communications

authors： Beck WS,Thorndike J

更新日期：1984-04-16 00:00:00

abstract：:DJ-1 is a multi-functional protein that plays roles in transcriptional regulation and anti-oxidative stress, and loss of its function is thought to result in onset of Parkinson's disease. We have previously reported that L166P, a mutant DJ-1 found in Parkinson's disease patients, had no activity to prevent hydrogen pe...

journal_title：Biochemical and biophysical research communications

authors： Takahashi-Niki K,Niki T,Taira T,Iguchi-Ariga SM,Ariga H

更新日期：2004-07-23 00:00:00

abstract：:Calpain was generally believed to exist and function only in the cytoplasm. However, m-calpain has now been detected in the extracellular spaces of some kinds of tissue. In this study, we demonstrated the existence of m-calpain in the medium surrounding MC3T3-E1 cultures, and its activity by zymography. At the same ti...

journal_title：Biochemical and biophysical research communications

authors： Nishihara H,Nakagawa Y,Ishikawa H,Ohba M,Shimizu K,Nakamura T

更新日期：2001-07-20 00:00:00

abstract：:The carboxyl terminus of the type 1 angiotensin II receptor (AT(1)) plays an important role in receptor phosphorylation, desensitization, and internalization. The yeast two-hybrid system was employed to isolate proteins associated with the carboxyl terminal region of the AT(1A) receptor. In the present study, we repor...

journal_title：Biochemical and biophysical research communications

authors： Guo DF,Chenier I,Tardif V,Orlov SN,Inagami T

更新日期：2003-10-31 00:00:00

abstract：:The cellular actions of nerve growth factor (NGF) involve regulation of protein phosphorylation. In PC-12 pheochromocytoma cells, exposure of [125I]NGF followed by crosslinking indicates that the ligand binds to two discreet receptors, the previously described 75 kd protein, as well as the trk proto-oncogene product p...

journal_title：Biochemical and biophysical research communications

authors： Ohmichi M,Decker SJ,Pang L,Saltiel AR

更新日期：1991-08-30 00:00:00

abstract：:Human prostatic acid phosphatase (hPAP) is intensely expressed in epithelial cells of the prostate gland following puberty. Its regulatory regions were analyzed in transgenic mice and cell line transfections, in order to clarify the mechanisms of tissue-specific gene expression. A construct containing the sequence of ...

journal_title：Biochemical and biophysical research communications

authors： Shan J,Porvari K,Kivinen A,Patrikainen L,Halmekytö M,Jänne J,Vihko P

更新日期：2003-11-28 00:00:00

abstract：:IL-13 mediates its effects through a complex receptor system including IL-4Ralpha and a functional IL-13Ralpha1. IL-13 has been reported to have no effects on mouse B cells due to a lack of receptor expression. However, on human B cells a functional IL-13Ralpha1 has been described. Here, we identified the rat IL-13Ral...

journal_title：Biochemical and biophysical research communications

authors： Pierrot C,Beniguel L,Bègue A,Khalife J

更新日期：2001-10-05 00:00:00

abstract：:The 100,000 x g supernatant of bovine heart has been chromatographed on DEAE-cellulose and the resultant fractions have been analyzed for both calcium binding activity and calmodulin activity. Of the four peaks of calcium binding activity detected by this procedure only a single peak (peak IV) was identified as calmod...

journal_title：Biochemical and biophysical research communications

authors： Waisman DM,Khanna NC,Tokuda M

更新日期：1986-09-14 00:00:00

abstract：:Alveolar epithelial type II cells (ATII cells) are the main target cells being damaged and releasing the inflammatory mediators during acute respiratory distress syndrome (ARDS). Extensive apoptosis of epithelial cells leads to the breakdown of the alveolar-epithelial barrier in ARDS. Cyclooxygenase-2 (COX-2) plays an...

journal_title：Biochemical and biophysical research communications

authors： Sun J,Zheng S,Yang N,Chen B,He G,Zhu T

更新日期：2019-09-10 00:00:00

abstract：:Conjugated linoleic acid (CLA), a group of minor fatty acids from ruminant origin, has long been recognized as a body fat lowering agent. Given the trans(t)10,cis(c)12-CLA well documented interference on lipolysis, we hypothesized for adipocytes altered permeation to glycerol when supplemented with this isomer. 3T3-L1...

journal_title：Biochemical and biophysical research communications

authors： Martins SV,Madeira A,Lopes PA,Pires VM,Alfaia CM,Prates JA,Moura T,Soveral G

更新日期：2015-03-06 00:00:00

abstract：:It is well-known that electrical stimulation can prompt healing of bone fractures. However, the mechanism involved is less clear. In this study, we found that capacitively coupled electric field-induced proliferation of osteoblastic cells (MC3T3-E1) accompanied increased levels of transforming growth factor-beta 1 (TG...

journal_title：Biochemical and biophysical research communications

authors： Zhuang H,Wang W,Seldes RM,Tahernia AD,Fan H,Brighton CT

更新日期：1997-08-18 00:00:00

abstract：:Downregulation of beta adrenergic receptors (beta-AR) by amiodarone (Am) have been reported in several studies both in vivo and in vitro. The mechanism underlying the antiadrenergic effect of Am is, however, still unclear. The aim of this study was to characterize whether the antiadrenergic effect of amiodarone is due...

journal_title：Biochemical and biophysical research communications

authors： Drvota V,Häggblad J,Blange I,Magnusson Y,Sylvén S

更新日期：1999-02-16 00:00:00

abstract：:To understand the regulation by thyroid hormone, 3,3',5-triiodo-L-thyronine (T3), of the synthesis of a cytosolic thyroid hormone binding protein (p58-M2) during liver regeneration, the synthesis of p58-M2 was evaluated. The synthesis of p58-M2 was measured by metabolic labeling of primary cultures derived from the re...

journal_title：Biochemical and biophysical research communications

authors： Obata T,Cheng SY

更新日期：1992-11-30 00:00:00

abstract：:We examined the intracellular localization of the myosin binding subunit (MBS) of smooth muscle myosin phosphatase. In MDCK cells in a confluent monolayer of polarized epithelial sheet, MBS was concentrated to the cell-cell adhesion sites. Double-immunofluorescence analysis with anti-MBS and anti-beta-catenin antibodi...

journal_title：Biochemical and biophysical research communications

authors： Inagaki N,Nishizawa M,Ito M,Fujioka M,Nakano T,Tsujino S,Matsuzawa K,Kimura K,Kaibuchi K,Inagaki M

更新日期：1997-01-23 00:00:00

abstract：:Each chromosome occupies its own-specific space called a 'territory' within the interphase nucleus, and the arrangement of chromosome territories (CTs) is important in epigenetic mechanisms. The molecular mechanism to determine the positioning of CTs, however, remains unknown. On the other hand, dioxin is known to be ...

journal_title：Biochemical and biophysical research communications

authors： Oikawa K,Yoshida K,Takanashi M,Tanabe H,Kiyuna T,Ogura M,Saito A,Umezawa A,Kuroda M

更新日期：2008-09-19 00:00:00

abstract：:Urocotins (Ucns) are newly discovered members of the corticotropin-releasing factor (CRF) neuropeptide family. Ucn 2 is expressed in the adrenal medulla, and its receptor, CRF2 receptor, is also expressed in the adrenal gland. To predict the physiological significance of Ucn 2 expression in the adrenal medulla, we exa...

journal_title：Biochemical and biophysical research communications

authors： Nemoto T,Mano-Otagiri A,Shibasaki T

更新日期：2005-05-13 00:00:00

abstract：:K63-linked polyubiquitination of proteins regulates their trafficking into specific cellular pathways such as endocytosis and autophagy. CYLD, a deubiquitinase specific for K63-linked polyubiquitins, is present in high quantities at the postsynaptic density (PSD). It was previously shown that, under excitatory conditi...

journal_title：Biochemical and biophysical research communications

authors： Thein S,Pham A,Bayer KU,Tao-Cheng JH,Dosemeci A

更新日期：2014-07-18 00:00:00

abstract：:N1999A2 (NA2) is a new non-protein antitumor antibiotic that contains a stable 9-membered ring enediyne chromophore similar to a neocarzinostatin chromophore (NCS-chr). We have compared DNA cleavage reactions between NA2 and NCS-chr, and also clarified some characteristics of DNA strand scission by NA2. It was found t...

journal_title：Biochemical and biophysical research communications

authors： Miyagawa N,Sasaki D,Matsuoka M,Imanishi M,Ando T,Sugiura Y

更新日期：2003-06-20 00:00:00

abstract：:In order to isolate new subtypes of P2Y purinoceptors, a human placenta cDNA library was screened at middle stringency with a P2Y4 probe. The purification and the sequencing of several clones led us to identify a 984 base pair open reading frame encoding a new human P2Y receptor. It appeared later that this sequence c...

journal_title：Biochemical and biophysical research communications

authors： Communi D,Parmentier M,Boeynaems JM

更新日期：1996-05-15 00:00:00

abstract：:Inducible nitric oxide (iNOS) is closely correlated with chronic inflammation in hepatitis B virus X protein (HBx)-induced hepatocellular carcinoma (HCC). However, the molecular mechanisms through which iNOS contribute to hepatocarcinogenesis remain poorly understood. Therefore, we investigated the role of iNOS in sig...

journal_title：Biochemical and biophysical research communications

authors： Park YH,Shin HJ,Kim SU,Kim JM,Kim JH,Bang DH,Chang KT,Kim BY,Yu DY

更新日期：2013-05-31 00:00:00

abstract：:GLUT4, the insulin-responsive glucose transporter expressed primarily in muscle and adipose tissue, contains a single N-glycosylation site. We characterized a mutant GLUT4 lacking the N-glycosylation site (Asn57-->Gln) in primary cultures of rat adipose cells. We transiently transfected cells with expression vectors f...

journal_title：Biochemical and biophysical research communications

authors： Ing BL,Chen H,Robinson KA,Buse MG,Quon MJ

更新日期：1996-01-05 00:00:00

abstract：:The cytoplasmic Ca2+ concentration (Ca2+i) was measured in single pancreatic beta-cells from ob/ob-mice using the fluorescent indicator fura-2. Raising the glucose concentration from 3 to 20 mM resulted in 25% initial lowering of Ca2+i, followed by 250% rise above the basal level of 49 +/- 3 nM. Tolbutamide (100 micro...

journal_title：Biochemical and biophysical research communications

authors： Grapengiesser E,Gylfe E,Hellman B

更新日期：1988-01-15 00:00:00

abstract：:Plasma high density lipoprotein (HDL)-cholesterol levels are inversely correlated to the risk of atherosclerotic cardiovascular diseases. Reverse cholesterol transport (RCT) is one of the major protective systems against atherosclerosis, in which HDL particles play a crucial role to carry cholesterol derived from peri...

journal_title：Biochemical and biophysical research communications

authors： Tsubakio-Yamamoto K,Matsuura F,Koseki M,Oku H,Sandoval JC,Inagaki M,Nakatani K,Nakaoka H,Kawase R,Yuasa-Kawase M,Masuda D,Ohama T,Maeda N,Nakagawa-Toyama Y,Ishigami M,Nishida M,Kihara S,Shimomura I,Yamashita S

更新日期：2008-10-24 00:00:00

abstract：:Deoxyribozymes or DNAzyme are identified as catalytic DNA sequences which catalyze different chemical reactions. Ligating deoxyribozymes catalyze the formation of branched and linear products. Due to the lack of efficient read-out systems, there is no report on in vivo application of ligating deoxyribozymes. To expand...

journal_title：Biochemical and biophysical research communications

authors： Dehghanian F,Najafi ZB,Hojati Z,Javadi-Zarnaghi F

更新日期：2020-04-02 00:00:00

abstract：:We have reported that activation of protein kinase C (PKC) increases ecto-5'-nucleotidase activity, which may contribute to the infarct size-limiting effect of ischemic preconditioning. Since we have reported that Ca(2+)- and phospholipid-sensitive PKC is activated due to ischemic preconditioning, we further tested 1)...

journal_title：Biochemical and biophysical research communications

authors： Kitakaze M,Funaya H,Minamino T,Node K,Sato H,Ueda Y,Okuyama Y,Kuzuya T,Hori M,Yoshida K

更新日期：1997-10-09 00:00:00

abstract：:Cancer metastasis involves tumor cells invading the surrounding tissue. Remodeling of tissue barriers depends on the ability of tumor cells to degrade the surrounding collagen matrix and then migrate through the matrix defects. Epidermal growth factor (EGF) has been shown to regulate tumor cell invasion through activa...

journal_title：Biochemical and biophysical research communications

authors： Binker MG,Binker-Cosen AA,Richards D,Oliver B,Cosen-Binker LI

更新日期：2009-02-06 00:00:00

abstract：:The lectin wheat germ agglutinin (WGA) elicited a prompt and sharp increase in intracellular Ca2+ concentration in human platelets. The WGA-induced Ca2+ mobilization was markedly inhibited by a protein kinase inhibitor staurosporine, whereas Ca2+ mobilization by receptor-mediated agonists, including thrombin, platelet...

journal_title：Biochemical and biophysical research communications

authors： Yatomi Y,Ozaki Y,Koike Y,Satoh K,Kume S

更新日期：1993-03-15 00:00:00

abstract：:Pinin (Pnn) is a nuclear speckle-associated SR-like protein. The N-terminal region of the Pnn protein sequence is highly conserved from mammals to insects, but the C-terminal RS domain-containing region is absent in lower species. The N-terminal coiled-coil domain (CCD) is, therefore, of interest not only from a funct...

journal_title：Biochemical and biophysical research communications

authors： Wu HP,Hsu SY,Wu WA,Hu JW,Ouyang P

更新日期：2014-01-03 00:00:00

abstract：:Arginine kinase catalyzes the reversible transfer of a phosphoryl group between ATP and l-arginine and is a monomeric homolog of the human enzyme creatine kinase. Arginine and creatine kinases belongs to the phosphagen kinase family of enzymes, which consists of eight known members, each of which is specific for its o...

journal_title：Biochemical and biophysical research communications

authors： Clark SA,Davulcu O,Chapman MS

更新日期：2012-10-12 00:00:00

abstract：:Affinity column-purified GABA-benzodiazepine receptor protein from bovine brain was photoaffinity labeled with both [3H]flunitrazepam and [3H]muscimol. Gel electrophoresis in sodium dodecyl sulfate revealed that the benzodiazepine binding site labeled with [3H]flunitrazepam was primarily associated with a major peptid...

journal_title：Biochemical and biophysical research communications

authors： Deng L,Ransom RW,Olsen RW

更新日期：1986-08-14 00:00:00