Dioxin interferes in chromosomal positioning through the aryl hydrocarbon receptor.

abstract：:Neuromedin B and neuromedin C are the novel mammalian bombesin-like peptides isolated from porcine spinal cord. We have developed highly specific and sensitive radioimmunoassays for neuromedin B and neuromedin C, and determined their regional distribution in rat central nervous system. Prior to measurements of the tis...

journal_title：Biochemical and biophysical research communications

authors： Minamino N,Kangawa K,Matsuo H

更新日期：1984-11-14 00:00:00

abstract：:The TCP transcription factors control important aspects of plant development. Members of class I TCP proteins promote cell cycle by regulating genes directly involved in cell proliferation. In contrast, members of class II TCP proteins repress cell division. While it has been postulated that class II proteins induce d...

journal_title：Biochemical and biophysical research communications

authors： Aggarwal P,Padmanabhan B,Bhat A,Sarvepalli K,Sadhale PP,Nath U

更新日期：2011-07-01 00:00:00

abstract：:The effect of subchronic intracerebroventricular (i.c.v.) injection of the human immunodeficiency virus type 1 (HIV-1) recombinant protein gp120 (100 ng, given daily for up to 7 consecutive days) on cyclooxygenase type 2 (COX-2) expression was studied by immunohistochemistry in the brain of adult rats. In comparison t...

journal_title：Biochemical and biophysical research communications

authors： Bagetta G,Corasaniti MT,Paoletti AM,Berliocchi L,Nisticò R,Giammarioli AM,Malorni W,Finazzi-Agrò A

更新日期：1998-03-27 00:00:00

abstract：:Hypothetical lambda protein ORF314 shows significant homology with the carboxyl end of phage T4 tail-fiber protein gp37. Homology can also be demonstrated between hypothetical lambda protein ORF194 and a fragment of bacteriophage T4 protein gp38. This sequence homology is also reflected in the genomic sequences of the...

journal_title：Biochemical and biophysical research communications

authors： George DG,Yeh LS,Barker WC

更新日期：1983-09-30 00:00:00

abstract：:Fura-2 loaded pancreatic beta-cells, isolated from obese hyperglycemic mice, were studied with respect to cytoplasmic free Ca2+ concentration ([Ca2+]i), insulin release and efflux of indicator. In the absence of glucose there was a continuous efflux of fura-2, which was markedly increased by stimulation with a high co...

journal_title：Biochemical and biophysical research communications

authors： Arkhammar P,Nilsson T,Berggren PO

更新日期：1989-02-28 00:00:00

abstract：:The intrinsic fluorescence properties of human alpha apohemoglobin at protein concentrations from 1 to 5 microM in 0.1 M potassium phosphate buffer, pH 7 or 8 at 5 degrees C were monitored in the absence and presence of a fixed concentration (5 microM) of a fluorescence quenching heme-containing native or Des (146-His...

journal_title：Biochemical and biophysical research communications

authors： Chiu F,Vasudevan G,Morris A,McDonald MJ

更新日期：1998-01-14 00:00:00

abstract：:Dipeptidyl-peptidase 4 [DPP-4) has evolved into an important target in diabetes therapy due to its role in incretin hormone metabolism. In contrast to its systemic effects, cellular functions of membranous DPP-4 are less clear. Here we studied the role of DPP-4 in hepatic energy metabolism. In order to distinguish sys...

journal_title：Biochemical and biophysical research communications

authors： Rufinatscha K,Radlinger B,Dobner J,Folie S,Bon C,Profanter E,Ress C,Salzmann K,Staudacher G,Tilg H,Kaser S

更新日期：2017-04-01 00:00:00

abstract：:Coronary collateral circulation (CCC) functions as a natural bypass in the event of coronary obstruction, which markedly improves prognosis in patients with coronary artery disease (CAD). MicroRNAs (miRNAs) have been implicated in multiple physiological and pathological processes, including angiogenesis involved in CC...

journal_title：Biochemical and biophysical research communications

authors： Hou S,Fang M,Zhu Q,Liu Y,Liu L,Li X

更新日期：2017-02-26 00:00:00

abstract：:To investigate the role of activation of c-Jun NH2-terminal kinase 1 (JNK1) in mediating cisplatin-induced apoptosis and the possibility of induction of JNK activity in triggering relation to DNA damage and drug resistance. We investigated the difference of cisplatin-induced activation of JNK pathway and H2O2 alterati...

journal_title：Biochemical and biophysical research communications

authors： Li F,Meng L,Zhou J,Xing H,Wang S,Xu G,Zhu H,Wang B,Chen G,Lu YP,Ma D

更新日期：2005-10-07 00:00:00

abstract：:Hedgehog (Hh) signaling plays key roles in animal development and tissue homeostasis. Binding of the secreted ligand to its Ptch1 receptor triggers Hh signaling through distinct canonical or noncanonical signaling pathways. Canonical Hh signaling leads to the activation of Gli transcription factors to induce Hh target...

journal_title：Biochemical and biophysical research communications

authors： Lee H,Ko HW

更新日期：2016-11-25 00:00:00

abstract：:PRPK (p53-related protein kinase) has been reported as a novel protein kinase which binds to the tumor suppressor protein p53 and induces phosphorylation of p53 at Ser 15. To identify novel binding partners of PRPK, we performed a yeast two-hybrid screening and isolated an expressed sequence tag CGI-121 by which a 20-...

journal_title：Biochemical and biophysical research communications

authors： Miyoshi A,Kito K,Aramoto T,Abe Y,Kobayashi N,Ueda N

更新日期：2003-04-04 00:00:00

abstract：:Nrf2 is a key regulator of many detoxifying enzyme genes, and cytoplasmic protein Keap1 represses the Nrf2 activity under quiescent conditions. Germ line deletion of the keap1 gene results in constitutive activation of Nrf2, but the pups unexpectedly died before weaning. To investigate how constitutive activation of N...

journal_title：Biochemical and biophysical research communications

authors： Okawa H,Motohashi H,Kobayashi A,Aburatani H,Kensler TW,Yamamoto M

更新日期：2006-01-06 00:00:00

abstract：:C-type natriuretic peptide (CNP), which was recently found to be a selective ligand for one of the two known natriuretic peptide receptor guanylyl cyclases (NPR-B), potently stimulates cGMP production in cultured rat vascular smooth muscle cells (VSMC) and exerts potent antiproliferative effects on the cells. To inves...

journal_title：Biochemical and biophysical research communications

authors： Furuya M,Tawaragi Y,Minamitake Y,Kitajima Y,Fuchimura K,Tanaka S,Minamino N,Kangawa K,Matsuo H

更新日期：1992-03-31 00:00:00

abstract：:Thymosin beta15 (Tbeta15) is a pleiotropic factor which exerts multiple roles in the development of nervous system and brain diseases. In this study, we found that the expressions of Tbeta15 mRNA and protein were substantially increased in several brain regions including hippocampal formation and cerebral cortex, foll...

journal_title：Biochemical and biophysical research communications

authors： Kim YW,Kim Y,Kim EH,Koh D,Sun W,Kim H

更新日期：2008-07-11 00:00:00

abstract：:Protocols were defined that enable patch-clamp studies of the approximately 107 pS voltage dependent channel and a class of activity we refer to as MCC (multiconductance channel) which is characterized by multiple levels and transitions as high as 1 to 1.5 nS. If free calcium was kept at 10(-7) M or lower during mitoc...

journal_title：Biochemical and biophysical research communications

authors： Kinnally KW,Zorov D,Antonenko Y,Perini S

更新日期：1991-05-15 00:00:00

abstract：:Different groups including ours have shown that curcumin induces melanoma cell apoptosis, here we focused the role of mammalian Sterile 20-like kinase 1 (MST1) in it. We observed that curcumin activated MST1-dependent apoptosis in cultured melanoma cells. MST1 silencing by RNA interference (RNAi) suppressed curcumin-i...

journal_title：Biochemical and biophysical research communications

authors： Yu T,Ji J,Guo YL

更新日期：2013-11-08 00:00:00

abstract：:Nuclear-Factor-kappaB (NF-kappaBeta can counteract transforming growth factor-beta1 (TGF-beta1)-induced apoptosis in malignant hepatocytes through up-regulation of its downstream genes, such as X-linked inhibitor of apoptosis protein (XIAP). Reports have demonstrated that TGF-beta1 can induce oxidative stress, and c-J...

journal_title：Biochemical and biophysical research communications

authors： Wang F,Kaur S,Cavin LG,Arsura M

更新日期：2008-12-26 00:00:00

abstract：:By DNA sequence analysis, we have determined a spectrum of 61 spontaneous mutations occurring in the endogenous tonB gene in the polA1 strain of Escherichia coli. The overall mutation frequency was approximately 2.4-fold higher in the polA1 strain and this was attributable to enhanced rates of deletion and frameshift ...

journal_title：Biochemical and biophysical research communications

authors： Agemizu Y,Uematsu N,Yamamoto K

更新日期：1999-08-11 00:00:00

abstract：:Osteoclastogenesis is dependent on distinct stimuli that prime and activate osteoclast differentiation. One cytokine needed to prime monocytes for osteoclastogenesis is TGF-beta, which enables and augments RANKL and TNF-alpha-induced osteoclast differentiation. However, the precise time-period during which this occurs...

journal_title：Biochemical and biophysical research communications

authors： Fox SW,Evans KE,Lovibond AC

更新日期：2008-02-01 00:00:00

abstract：:The maximal activity of the enzymes hexokinase and 6-phosphofructokinase were measured in interscapular brown adipose tissue during ageing in the rat. The activity of these glycolytic enzymes increased markedly during the suckling-weaning transition (20-22 days of age), but from 30 to 100 days of age the activities pe...

journal_title：Biochemical and biophysical research communications

authors： Simpson ML,Cooney GJ,Caterson ID,Newsholme EA

更新日期：1986-10-15 00:00:00

abstract：:Deregulated activation of protein tyrosine kinases, such as the epidermal growth factor receptor (EGFR) and Abl, is associated with human cancers including non-small cell lung cancer (NSCLC) and chronic myeloid leukemia (CML). Although inhibitors of such activated kinases have proved to be of therapeutic benefit in in...

journal_title：Biochemical and biophysical research communications

authors： Ozaki K,Kosugi M,Baba N,Fujio K,Sakamoto T,Kimura S,Tanimura S,Kohno M

更新日期：2010-01-22 00:00:00

abstract：:A melanin (melanosome) concentrating hormone, MCH, was synthesized and the methodology for its synthesis is detailed. This heptadecapeptide, H-Asp-Thr-Met-Arg-Cys-Met-Val-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Trp-Glu-Val-OH , stimulated melanosome concentration (centripetal aggregation) within melanophores of all species of tel...

journal_title：Biochemical and biophysical research communications

authors： Wilkes BC,Hruby VJ,Sherbrooke WC,Castrucci AM,Hadley ME

更新日期：1984-07-31 00:00:00

abstract：:Thyroid hormone (T3) responsiveness of the PEPCK promoter in vivo was examined in both PEPCK/bGH(460) and PEPCK/bGH(335) mouse lines. Transgenic and non-transgenic littermates were treated with methimazole or PTU for 6 or 4 weeks, respectively, then treated +/- T3 for 10 days. In PEPCK/bGH(460) and PEPCK/bGH(355) tran...

journal_title：Biochemical and biophysical research communications

authors： Xu C,McGrane MM

更新日期：1996-01-17 00:00:00

abstract：:Highly purified bovine heart protein phosphatase 2A catalytic subunit lost virtually all of its activity during storage at -70 degrees. When the enzyme was preincubated with Co2+, over 35% of the original activity was restored. Freshly prepared protein phosphatase 2A purified from bovine heart was stimulated at least ...

journal_title：Biochemical and biophysical research communications

authors： Cai L,Chu Y,Wilson SE,Schlender KK

更新日期：1995-03-08 00:00:00

abstract：:In our efforts to identify immunoreactive antigens in ovarian cancer, we used the method of immunoscreening of an ovarian carcinoma cDNA expression library with ascites fluid from ovarian cancer patients. Among many positive clones, one was found to contain partial sequence of a novel gene. By searching expressed sequ...

journal_title：Biochemical and biophysical research communications

authors： Luo LY,Soosaipillai A,Diamandis EP

更新日期：2001-01-12 00:00:00

abstract：:HSV-2 induces the transcription of c-fos gene in both human (diploid) cell strains and mouse (heteroploid) cell lines. HSV-1 is incapable of such induction. The induction of transcription is rapid and transient in both cell types. The product of transcriptional induction of c-fos in mouse cells is mainly a 4.5 kb fos ...

journal_title：Biochemical and biophysical research communications

authors： Goswami BB

更新日期：1987-03-30 00:00:00

abstract：:The characterization of the genomic organization of the B2 bradykinin receptor gene enabled us to systematically search for polymorphic markers in this gene in a South German cohort (N = 179). We identified at least three polymorphic sites in each of the three exons existing: (i) in exon 1 next to the promoter region,...

journal_title：Biochemical and biophysical research communications

authors： Braun A,Kammerer S,Böhme E,Müller B,Roscher AA

更新日期：1995-06-06 00:00:00

abstract：:Crystallographic studies have shown independent binding sites for sugar and peptide ligands of concanavalin A, although they were considered functional mimics based on biochemical experiments. The topological correlation of 12-residue peptide with different carbohydrate ligands of concanavalin A showed similarity betw...

journal_title：Biochemical and biophysical research communications

authors： Jain D,Kaur KJ,Goel M,Salunke DM

更新日期：2000-06-16 00:00:00

abstract：:In spite of intensive research, our understanding of the regulation of expression of 5-LO (the key enzyme in the leukotriene metabolism) remains fragmentary. We investigated the effects of dexamethasone on the expression of this gene in a binary model consisting of two clones of the human mast cell line HMC-1, one wit...

journal_title：Biochemical and biophysical research communications

authors： Colamorea T,Di Paola R,Macchia F,Guerrese MC,Tursi A,Butterfield JH,Caiaffa MF,Haeggström JZ,Macchia L

更新日期：1999-11-30 00:00:00

abstract：:Although chronic voluntary physical activity has been shown to enhance hippocampal brain-derived neurotrophic factor (BDNF) expression in animals, the effects of forced exercise on a treadmill have not been fully investigated. We assessed induction of c-fos and BDNF expression with acute exercise at different running ...

journal_title：Biochemical and biophysical research communications

authors： Soya H,Nakamura T,Deocaris CC,Kimpara A,Iimura M,Fujikawa T,Chang H,McEwen BS,Nishijima T

更新日期：2007-07-13 00:00:00