当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Tissue-specific expression of the prostatic acid phosphatase promoter constructs.

Tissue-specific expression of the prostatic acid phosphatase promoter constructs.

Abstract：

:Human prostatic acid phosphatase (hPAP) is intensely expressed in epithelial cells of the prostate gland following puberty. Its regulatory regions were analyzed in transgenic mice and cell line transfections, in order to clarify the mechanisms of tissue-specific gene expression. A construct containing the sequence of hPAP between the nucleotides -734 and +467 in front of the CAT reporter gene was significantly expressed in the prostate of transgenic mice, while the proximal promoter -734/+50 alone achieved low levels of CAT mRNA in all tissues analyzed. Five homologous sequences (A-E) for our previously identified prostatic GAAAATATGATA DNA-binding site were found in the area. The competitive reactions in electrophoretic mobility shift assays suggested that the same nuclear factor binds to the GAAAATATGATA and the sites C and E. The importance of the intronic area +57/+467 on the androgen-activated expression in prostatic cells was shown by the reporter construct containing heterologous promoter.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Shan J,Porvari K,Kivinen A,Patrikainen L,Halmekytö M,Jänne J,Vihko P

doi

10.1016/j.bbrc.2003.10.071

subject

Has Abstract

pub_date

2003-11-28 00:00:00

pages

864-9

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006291X03021703

journal_volume

311

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Monocyte-derived cells express CYP27A1 and convert vitamin D3 into its active metabolite.

    abstract：:CYP27A1 catalyses hydroxylations in the biosynthesis of bile acids and the bioactivation of vitamin D3. We investigated the expression of CYP27A1 in human monocytes, monocyte-derived macrophages, and dendritic cells on mRNA and protein levels as well as its enzymatic activity in comparison with the expression of CYP27...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.08.034

    authors： Gottfried E,Rehli M,Hahn J,Holler E,Andreesen R,Kreutz M

    更新日期：2006-10-13 00:00:00

  • VEGF-A and VEGF-F evoke distinct changes in vascular ultrastructure.

    abstract：:VEGF-induced vascular barrier disruptions, formation of fenestrae and vesiculo-vacuolar organelles (VVOs), are involved in enhancing vascular permeability in metastatic and edematous diseases. Here, we analyzed vascular permeability enhanced by VEGFs with different receptor selectivity using biological and ultrastruct...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.12.129

    authors： Matsunaga Y,Yamazaki Y,Suzuki H,Morita T

    更新日期：2009-02-20 00:00:00

  • Cloning of a mRNA preferentially expressed in chondrocytes by differential display-PCR from a human chondrocytic cell line that is identical with connective tissue growth factor (CTGF) mRNA.

    abstract：:Chondrocyte- or chondrosarcoma cell line (HCS)-specific DNA fragments were obtained using differential display-PCR. Nucleotide sequences of 32 species derived from HCS cells were determined. One of the sequence tags (tag no. 24) corresponded to the nucleotide sequence of connective tissue growth factor (CTGF). Norther...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.6528

    authors： Nakanishi T,Kimura Y,Tamura T,Ichikawa H,Yamaai Y,Sugimoto T,Takigawa M

    更新日期：1997-05-08 00:00:00

  • Applications of mass spectrometry-based targeted and non-targeted lipidomics.

    abstract：:Recent advances in mass spectrometry have expanded our knowledge of lipids and lipid metabolic pathways involved in many (patho)physiological events. Targeted and non-targeted lipidomics are powerful analytical strategies with distinct features, and a combination of these two approaches is often employed to maximize t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章,评审

    doi：10.1016/j.bbrc.2018.03.081

    authors： Lee HC,Yokomizo T

    更新日期：2018-10-07 00:00:00

  • DISC1, PDE4B, and NDE1 at the centrosome and synapse.

    abstract：:Disrupted-In-Schizophrenia 1 (DISC1) is a risk factor for schizophrenia and other major mental illnesses. Its protein binding partners include the Nuclear Distribution Factor E Homologs (NDE1 and NDEL1), LIS1, and phosphodiesterases 4B and 4D (PDE4B and PDE4D). We demonstrate that NDE1, NDEL1 and LIS1, together with t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.10.120

    authors： Bradshaw NJ,Ogawa F,Antolin-Fontes B,Chubb JE,Carlyle BC,Christie S,Claessens A,Porteous DJ,Millar JK

    更新日期：2008-12-26 00:00:00

  • Nested-polymerase chain reaction for the detection of Helicobacter pylori infection with novel primers designed by sequence analysis of urease A gene in clinically isolated bacterial strains.

    abstract：:We have established a highly sensitive semi-nested PCR assay for the detection of H. pylori infection using gastric juice samples, which can be aspirated with disposable nasogastric tubes. The primers targeting H. pylori urease A gene were designed based on the sequence conservation analysis of sixteen H. pylori strai...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.0216

    authors： Kawamata O,Yoshida H,Hirota K,Yoshida A,Kawaguchi R,Shiratori Y,Omata M

    更新日期：1996-02-06 00:00:00

  • Determination of the complete covalent structure of the gamma 2 subunit of bovine brain G proteins by mass spectrometry.

    abstract：:The complete covalent structure of the gamma 2 subunit of bovine brain G proteins was determined by peptide mapping using matrix-assisted laser desorption ionization and electrospray ionization mass spectrometry and by partial sequencing using tandem mass spectrometry. Fragments were identified in proteolytic digests ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1979

    authors： Wilcox MD,Schey KL,Busman M,Hildebrandt JD

    更新日期：1995-07-17 00:00:00

  • A malonyl-CoA-binding protein from liver.

    abstract：:A soluble protein that binds malonyl-CoA without requiring cofactors has been purified from rat liver. Until saturated, it competes with fatty acid synthetase for free malonyl-CoA, temporarily reducing the rate of fatty acid synthesis at low levels of malonyl-CoA, as in fatty acid synthetase--coupled assays for acetyl...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(87)80111-0

    authors： Dugan RE,Osterlund BR,Drong RF,Swenson TL

    更新日期：1987-08-31 00:00:00

  • A unique low frequency Raman band associated with metal binding to metallothionein.

    abstract：:We find that the low frequency Raman spectrum of Zn(II) metallothionein has a single prominent band at 138 cm-1 which is absent from the Raman spectrum of the metal-free protein. This feature is also found for Cd(II) binding to both of the independent metallothionein domains and the metallothionein from Neurospora cra...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)92333-4

    authors： Elgren TE,Wilcox DE

    更新日期：1989-09-15 00:00:00

  • Increased copper toxicity in Saccharomyces cerevisiae lacking VPS35, a component of the retromer and monogenic Parkinson disease gene in humans.

    abstract：:The Saccharomyces cerevisiae gene VPS35 encodes a component of the retromer complex which is involved in vesicle transport from endosomes to the trans-Golgi network. Yeast and human VPS35 orthologs are highly conserved and mutations in human VPS35 cause an autosomal dominant form of late-onset Parkinson disease (PD). ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.05.157

    authors： Sowada N,Stiller B,Kubisch C

    更新日期：2016-08-05 00:00:00

  • Dihydromyricetin sensitizes human acute myeloid leukemia cells to retinoic acid-induced myeloid differentiation by activating STAT1.

    abstract：:The success of all-trans retinoic acid (ATRA) in differentiation therapy for patients with acute promyelocytic leukemia (APL) highly encourages researches to apply a new combination therapy based on ATRA. Therefore, research strategies to further sensitize cells to retinoids are urgently needed. In this study, we show...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.12.030

    authors： He MH,Zhang Q,Shu G,Lin JC,Zhao L,Liang XX,Yin L,Shi F,Fu HL,Yuan ZX

    更新日期：2018-01-08 00:00:00

  • Identification and characterization of a unique leucine-rich repeat protein (LRRC33) that inhibits Toll-like receptor-mediated NF-κB activation.

    abstract：:Toll-like receptors (TLRs) are important initiators in innate immune responses against pathogenic microbes such as viruses, intracellular bacteria or parasites. Although the innate immune system is designed to fight infectious pathogens, excessive activation of TLR signaling may lead to unwarranted inflammation with h...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.03.071

    authors： Liu J,Zhang Z,Chai L,Che Y,Min S,Yang R

    更新日期：2013-04-26 00:00:00

  • Mature adipocyte-derived dedifferentiated fat cells can transdifferentiate into skeletal myocytes in vitro.

    abstract：:We have previously reported the establishment of preadipocyte cell lines, termed dedifferentiated fat (DFAT) cells, from mature adipocytes of various animals. DFAT cells possess long-term viability and can redifferentiate into adipocytes both in vivo and in vitro. Furthermore, DFAT cells can transdifferentiate into os...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.10.046

    authors： Kazama T,Fujie M,Endo T,Kano K

    更新日期：2008-12-19 00:00:00

  • Targeted disruption of inducible 6-phosphofructo-2-kinase results in embryonic lethality.

    abstract：:Inducible 6-phosphofructo-2-kinase (iPFK-2; PFKFB3) produces fructose-2,6-bisphosphate (F2,6BP), which is a potent allosteric activator of 6-phosphofructo-1-kinase (PFK-1), the rate-limiting step in glycolysis. iPFK-2 functions as an activator of anaerobic glycolysis within the hypoxic microenvironment of growing tumo...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.02.193

    authors： Chesney J,Telang S,Yalcin A,Clem A,Wallis N,Bucala R

    更新日期：2005-05-27 00:00:00

  • Interaction of peptide substrates of fibroblast collagenase with divalent cations: Ca2+ binding by substrate as a suggested recognition signal for collagenase action.

    abstract：:To correlate structural data on substrates of human fibroblast collagenase with their interaction with the enzyme, we have studied: Ac-PLG-s-LLG-O-ethyl ester (I), Dnp-PLGLWA(d-Arg)-NH2 (II), AcGPEGLRVG-O-ethyl ester (III) and Succ-GPLGP-O-amidomethylcoumaryl ester (IV). Peptides I and II represent collagenase cleavag...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.2489

    authors： Upadhye S,Ananthanarayanan VS

    更新日期：1995-10-13 00:00:00

  • Identification of the metal associated with the insulin degrading enzyme.

    abstract：:Insulin degrading enzyme (IDE) is a thiol-dependent metalloendoprotease that is responsible for initiation of cellular insulin degradation. However, its exact mode of action and the factors controlling it are poorly understood. Since IDE is a metal requiring enzyme, we have examined which metal(s) is(are) endogenously...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(91)92094-z

    authors： Ebrahim A,Hamel FG,Bennett RG,Duckworth WC

    更新日期：1991-12-31 00:00:00

  • Morin suppresses cachexia-induced muscle wasting by binding to ribosomal protein S10 in carcinoma cells.

    abstract：:Cachexia, observed in most cancer patients, is a syndrome that includes wasting of bodily energy reserves and is characterized by muscle atrophy and fat loss. We have previously demonstrated that isoflavones, such as genistein and daidzein, prevent muscle wasting in tumor-bearing mice. In this study, we examined the e...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.10.184

    authors： Yoshimura T,Saitoh K,Sun L,Wang Y,Taniyama S,Yamaguchi K,Uchida T,Ohkubo T,Higashitani A,Nikawa T,Tachibana K,Hirasaka K

    更新日期：2018-12-02 00:00:00

  • A single nucleotide polymorphism of CYP2b6 found in Japanese enhances catalytic activity by autoactivation.

    abstract：:A single nucleotide polymorphism (SNP) resulting in a substitution from Gln to His was found in exon 4 of the CYP2B6 gene in Japanese. The frequency of the variant allele was found to be 19.9%. The mutant- and the wild-type enzymes were expressed in Escherichia coli, and the effects of the single amino acid substituti...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.4524

    authors： Ariyoshi N,Miyazaki M,Toide K,Sawamura Yi,Kamataki T

    更新日期：2001-03-01 00:00:00

  • KSHV RTA induces a transcriptional repressor, HEY1 that represses rta promoter.

    abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) is a gamma-herpesvirus that is frequently associated with the formation of tumors like Kaposi's sarcoma and primary effusion lymphomas. KSHV RTA is required for lytic replication/reactivation in KSHV-infected cells. We developed an inducible RTA expression cell line to se...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.04.092

    authors： Yada K,Do E,Sakakibara S,Ohsaki E,Ito E,Watanabe S,Ueda K

    更新日期：2006-06-23 00:00:00

  • Sortilin facilitates VLDL-B100 secretion by insulin sensitive McArdle RH7777 cells.

    abstract：:Studies examining the relationship between cellular sortilin and VLDL-B100 secretion demonstrate inconsistent results. Current studies explore the possibility that discrepancies may be related to insulin sensitivity. McArdle RH7777 cells (McA cells) cultured under serum enriched conditions lose sensitivity to insulin....

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.07.096

    authors： Sparks RP,Guida WC,Sowden MP,Jenkins JL,Starr ML,Fratti RA,Sparks CE,Sparks JD

    更新日期：2016-09-16 00:00:00

  • Relative spectral response as a function of sequential ligand binding.

    abstract：:A unique method is presented for the determination of the critical number of ligands that must bind to a macromolecule to elicit a spectroscopic response. This method is based on analysis of ligand binding data. For example, four Ca2+ and two Mg2+ ions are necessary for mirroring the relative decrease in the intrinsic...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(86)80173-5

    authors： Deerfield DW 2nd,Hoke RA,Pedersen LG,Darden T,Hiskey RG

    更新日期：1986-12-30 00:00:00

  • Involvement of WNK1-mediated potassium channels in the sexual dimorphism of blood pressure.

    abstract：:Potassium homeostasis plays an essential role in the control of blood pressure. It is unknown, however, whether potassium balance is involved in the gender-associated blood pressure differences. We therefore investigated the possible mechanism of sexual dimorphism in blood pressure regulation by measuring the blood pr...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.02.098

    authors： Yu G,Cheng M,Wang W,Zhao R,Liu Z

    更新日期：2017-04-01 00:00:00

  • SNAP-23 and SNAP-25 are palmitoylated in vivo.

    abstract：:The neuronal presynaptic membrane t-SNARE complex consists of the transmembrane protein syntaxin with the palmitoylated protein SNAP-25. In non-neuronal tissues, SNAP-23 replaces SNAP-25 in the t-SNARE complex, although the mechanism of membrane anchoring of SNAP-23 has not been determined. We now report that like SNA...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.0652

    authors： Vogel K,Roche PA

    更新日期：1999-05-10 00:00:00

  • The Foxc2 transcription factor regulates tumor angiogenesis.

    abstract：:The Forkhead/Fox transcription factor Foxc2 is a critical regulator of vascular development. However, the role of Foxc2 in pathological angiogenesis in cancer remains unknown. Here we show that FoxC2 is highly expressed in human breast and colonic tumors and in the tumor endothelium in human and mouse melanomas. Using...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.01.015

    authors： Sano H,Leboeuf JP,Novitskiy SV,Seo S,Zaja-Milatovic S,Dikov MM,Kume T

    更新日期：2010-02-05 00:00:00

  • Up-regulation of p21- and RhoA-activated protein kinases in human pregnant myometrium.

    abstract：:The role of small ras homologous GTP-binding proteins in the regulation of smooth muscle contractility has become increasingly apparent but there is still little information about the presence of these proteins in human uterine smooth muscle. Messenger RNAs for p21-activated protein kinase isoforms (PAK1, PAK2, and PA...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.2290

    authors： Moore F,Da Silva C,Wilde JI,Smarason A,Watson SP,López Bernal A

    更新日期：2000-03-16 00:00:00

  • Activated p53 induces NF-kappaB DNA binding but suppresses its transcriptional activation.

    abstract：:NF-kappaB plays an important role in oncogenesis. Recently, we have demonstrated that loss of p53 function enhances DNA binding and transcriptional activities of NF-kappaB via IKKalpha and IKKbeta, and that glycolysis, activated by NF-kappaB, has an integral role in oncogene-induced cell transformation. Here, we show ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.05.021

    authors： Kawauchi K,Araki K,Tobiume K,Tanaka N

    更新日期：2008-07-18 00:00:00

  • Dietary cholesterol affects expression of prostatic acid phosphatase in reproductive organs of male rats.

    abstract：:Cholesterol homeostasis is strictly maintained to prevent abnormal biological processes that arise from excessive accumulation of cholesterol in tissues. Although dyslipidemia causes reproductive dysfunction and endocrine disruption in male rats, regulatory factors and mechanisms have not been clearly demonstrated. Th...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.11.100

    authors： Lim W,Bae H,Sohn JY,Jeong W,Kim SH,Song G

    更新日期：2015-01-02 00:00:00

  • Rapid cloning of rearranged immunoglobulin heavy chain genes from human B-cell lines using anchored polymerase chain reaction.

    abstract：:A general method to obtain the variable region DNA sequence of the immunoglobulin heavy chain using anchored polymerase chain reaction is described. Based on this DNA sequence, clone-specific oligonucleotides were designed to anneal to the complementarity determining regions. These were used to identify the original B...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(92)91867-p

    authors： Ratech H

    更新日期：1992-02-14 00:00:00

  • DRG: a novel developmentally regulated GTP-binding protein.

    abstract：:Using a subtraction cloning approach we had previously isolated a series of murine cDNA clones representing the genes predominantly expressed in the embryonic brain and down-regulated during development. We now report that one of these cDNA clones encodes a novel type of GTP-binding protein. The predicted protein of 4...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(92)91567-a

    authors： Sazuka T,Tomooka Y,Ikawa Y,Noda M,Kumar S

    更新日期：1992-11-30 00:00:00

  • Mechanisms of ascorbic acid stimulation of norepinephrine synthesis in neuronal cells.

    abstract：:Ascorbic acid is well known to acutely stimulate norepinephrine synthesis in neurosecretory cells, but it has also been shown over several days to increase tyrosine hydroxylase mRNA and norepinephrine synthesis in cultured neurons. Since tyrosine hydroxylase is the rate-limiting step in catecholamine synthesis, an eff...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.08.054

    authors： May JM,Qu ZC,Meredith ME

    更新日期：2012-09-14 00:00:00