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VEGF-A and VEGF-F evoke distinct changes in vascular ultrastructure.

Abstract：

:VEGF-induced vascular barrier disruptions, formation of fenestrae and vesiculo-vacuolar organelles (VVOs), are involved in enhancing vascular permeability in metastatic and edematous diseases. Here, we analyzed vascular permeability enhanced by VEGFs with different receptor selectivity using biological and ultrastructural methods. VEGF-A(165), which stimulates both Flt-1 and KDR, induced the formation of both fenestrae and VVOs at a similar rate, while VEGF-F, a KDR-specific VEGF vammin, predominantly induced the formation of fenestrae with an approximately 5-fold more potent vascular permeability response than VEGF-A(165). This is the first report showing that VEGFs with different receptor selectivity evoke distinct changes in vascular ultrastructure.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Matsunaga Y,Yamazaki Y,Suzuki H,Morita T

doi

10.1016/j.bbrc.2008.12.129

subject

Has Abstract

pub_date

2009-02-20 00:00:00

pages

872-5

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(08)02552-7

journal_volume

379

pub_type

杂志文章

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