Adiponectin increases bone mass by suppressing osteoclast and activating osteoblast.

abstract：:TRPA1 of insects and several tetrapod vertebrates except for those of rodents have been reported to be activated by noxious chemicals and also by high temperature with a relatively clear threshold. We previously analyzed the characteristics of two TRPA1 paralogs of zebrafish (zTRPA1a, b) and demonstrated that zTRPA1a ...

journal_title：Biochemical and biophysical research communications

authors： Oda M,Saito K,Hatta S,Kubo Y,Saitoh O

更新日期：2017-12-09 00:00:00

abstract：:The Ca(2+)-binding S100A1 protein displays a specific and high expression level in the human myocardium and is considered to be an important regulator of heart contractility. Diminished protein levels detected in dilated cardiomyopathy possibly contribute to impaired Ca(2+) handling and contractility in heart failure....

journal_title：Biochemical and biophysical research communications

authors： Kiewitz R,Acklin C,Schäfer BW,Maco B,Uhrík B,Wuytack F,Erne P,Heizmann CW

更新日期：2003-06-27 00:00:00

abstract：:CYP153 a cytochrome P450 from Acinetobacter sp. EB104 catalyzes the hydroxylation of unsubstituted n-alkanes. We have decided to use the CYP153 system as a model for mechanistic studies on regioselective n-alkane oxidation and the interaction of hydrophobic substrates with soluble enzymes. Here the molecular cloning o...

journal_title：Biochemical and biophysical research communications

authors： Maier T,Förster HH,Asperger O,Hahn U

更新日期：2001-08-24 00:00:00

abstract：:Fluorescent ubiquitination-based cell cycle indicator (Fucci) technology utilizing the cell cycle-dependent proteolysis of ubiquitin oscillators enables visualization of cell cycle progression in living cells. The Fucci probe consists of two chimeric fluorescent proteins, FucciS/G2/M and FucciG1, which label the nucle...

journal_title：Biochemical and biophysical research communications

authors： Yo M,Sakaue-Sawano A,Noda S,Miyawaki A,Miyoshi H

更新日期：2015-01-30 00:00:00

abstract：:Uncoupling proteins (UCPs) are mitochondrial membrane proton transporters that uncouple oxidative phosphorylation by dissipating the proton gradient across the membrane. We have investigated regulation of the UCP3 gene in skeletal muscle and C2C12 muscle cells. UCP3 mRNA in mouse skeletal muscle is markedly increased ...

journal_title：Biochemical and biophysical research communications

authors： Hwang CS,Lane MD

更新日期：1999-05-10 00:00:00

abstract：:Overexpression in Escherichia coli of the fdx4 gene from Aquifex aeolicus has allowed isolation and characterization of the first hyperthermophilic [2Fe-2S](Scys)(4) protein, a homodimer of M = 2 x 12.4 kDa with one [2Fe-2S] cluster per subunit. This protein is undamaged by heating to 100 degrees C for at least three ...

journal_title：Biochemical and biophysical research communications

authors： Chatelet C,Gaillard J,Pétillot Y,Louwagie M,Meyer J

更新日期：1999-08-11 00:00:00

abstract：:The fusion of myoblasts to myotubes requires an endogenous soluble metalloendoprotease. To determine whether this protease is released by fusing myoblasts, or stays within the cell, we examined the effects of membrane-impermeant and a membrane-permeant metalloendoprotease inhibitors. Membrane-permeant 1,10-phenanthrol...

journal_title：Biochemical and biophysical research communications

authors： Farach HA Jr,Strittmatter WJ

更新日期：1987-08-31 00:00:00

abstract：:The detergent (Triton X-100, 4°C)-resistant membrane (DRM)-associated membrane proteins stomatin, sorcin, and synexin (anexin VII) exposed on the cytoplasmic side of membrane were investigated for their lateral distribution in relation to induced ganglioside(M1) (GM1) raft patches in flat (discocytic) and curved (echi...

journal_title：Biochemical and biophysical research communications

authors： Mrówczyńska L,Salzer U,Perutková S,Iglič A,Hägerstrand H

更新日期：2010-10-22 00:00:00

abstract：:Th2 type immune responses are essential for protective immunity against parasites and play crucial roles in allergic disorders. Helminth parasites secrete a variety of proteases for their infectious cycles including for host entry, tissue migration, and suppression of host immune effector cell function. Furthermore, a...

journal_title：Biochemical and biophysical research communications

authors： Nishikado H,Fujimura T,Taka H,Mineki R,Ogawa H,Okumura K,Takai T

更新日期：2015-05-01 00:00:00

abstract：:Angiotensin II (Ang II) and oxidized LDL (Ox-LDL) are risk factors for atherosclerosis, and both of them contribute to macrophage cholesterol accumulation, the hallmark of early atherosclerosis. As Ang II was shown to increase macrophage uptake of Ox-LDL, we investigated the effect of losartan, an Ang II receptor anta...

journal_title：Biochemical and biophysical research communications

authors： Hayek T,Aviram M,Heinrich R,Sakhnini E,Keidar S

更新日期：2000-07-05 00:00:00

abstract：:Platelet-derived growth factor (PDGF)-BB elicits a migratory response including reorganization of the actin cytoskeleton in different cell types. Here we have investigated the effects of PDGF-BB stimulation on beta(1) integrin containing focal adhesions in human diploid fibroblasts adhered to collagen type I. Stimulat...

journal_title：Biochemical and biophysical research communications

authors： Ahlén K,Ring P,Tomasini-Johansson B,Holmqvist K,Magnusson KE,Rubin K

更新日期：2004-01-30 00:00:00

abstract：:Disturbances of serotonergic pathways have been implicated in a wide variety of neuropsychiatric disorders such as depression, anxiety, migraine, and substance abuse. Genetic variation in genes coding for serotonin receptor proteins might well be involved in the genetic predisposition to these diseases and/or of pharm...

journal_title：Biochemical and biophysical research communications

authors： Nöthen MM,Erdmann J,Shimron-Abarbanell D,Propping P

更新日期：1994-12-15 00:00:00

abstract：:Expression of the nm23/NDP-K gene correlates with reduced metastasis in some tumors and with increased proliferation in both nontransformed and transformed cells in culture. Decreased nm23/NDP-K expression results in mitotic arrest in neuroblasts of developing Drosophila. In order to better understand the biological r...

journal_title：Biochemical and biophysical research communications

authors： Sorscher SM,Steeg P,Feramisco JR,Buckmaster C,Boss GR,Meinkoth J

更新日期：1993-08-31 00:00:00

abstract：:Secretion of growth hormone (GH) exhibits marked sexual dimorphism in the rat. To examine the underlying mechanism that involves hypothalamic GH-releasing factor (GRF), we determined pituitary GRF receptor mRNA levels in male and female rats and compared their in vitro abilities to release GRF, an endogenous ligand fo...

journal_title：Biochemical and biophysical research communications

authors： Ono M,Miki N,Murata Y,Osaki E,Tamitsu K,Ri T,Yamada M,Demura H

更新日期：1995-11-22 00:00:00

abstract：:Male rats were exposed to freshly generated cigarette smoke once daily for 4 to 8 weeks. Inhalation of smoke was verified by elevated level of carboxyhemoglobin. Arachidonate metabolism through lipoxygenase and cyclooxygenase pathways in platelets was determined. Cigarette smoking increased 12-lipoxygenase activity si...

journal_title：Biochemical and biophysical research communications

authors： Chang WC,Fukuda S,Tai HH

更新日期：1983-09-15 00:00:00

abstract：:Angiogenesis is critical to a wide range of physiological and pathological processes. Scutellarin, a major flavonoid of a Chinese herbal medicine Erigeron breviscapus (Vant.) Hand. Mazz. has been shown to offer beneficial effects on cardiovascular and cerebrovascular functions. However, scutellarin's effects on angiog...

journal_title：Biochemical and biophysical research communications

authors： Gao ZX,Huang DY,Li HX,Zhang LN,Lv YH,Cui HD,Zheng JH

更新日期：2010-09-10 00:00:00

abstract：:Streptavidin, which is one of the most widely used proteins in biotechnological application field and is active only in tetrameric form, was surface expressed on the surface of Bacillus subtilis spore. Spore coat protein of B. subtilis, CotG, was used as an anchoring motif to display streptavidin. FACS using anti-stre...

journal_title：Biochemical and biophysical research communications

authors： Kim JH,Lee CS,Kim BG

更新日期：2005-05-27 00:00:00

abstract：:Hepatitis A virus (HAV) protein 3AB is a membrane-interacting protein containing a stretch of 21 hydrophobic amino acid residues. The nature of its membrane association was studied in detail by analysing various deletion mutants. In vivo and in vitro expression of the wild-type protein and its mutants allowed to demon...

journal_title：Biochemical and biophysical research communications

authors： Ciervo A,Beneduce F,Morace G

更新日期：1998-08-10 00:00:00

abstract：:We previously showed that p21-activated kinase 2 (PAK2), a major PAK isoform expressed in PC12 cells, mediates neurite outgrowth via Rac1 GTPase. RhoGDI1 forms a complex with Rac1, resulting in its inhibition. Rac1 activation requires dissociation from RhoGDI1. Here, we show that PAK2 mediates basic fibroblast growth ...

journal_title：Biochemical and biophysical research communications

authors： Shin EY,Shim ES,Lee CS,Kim HK,Kim EG

更新日期：2009-02-06 00:00:00

abstract：:Myofibrillogenesis regulator-1(MR-1) can aggravate cardiac hypertrophy induced by angiotensin(Ang) II in mice through activation of NF-kappaB signaling pathway, and nuclear transcription factor (NF)-kappaB and activator protein-1(AP-1) regulate inflammatory and immune responses by increasing the expression of specific...

journal_title：Biochemical and biophysical research communications

authors： Dai W,Chen H,Jiang J,Kong W,Wang Y

更新日期：2010-01-15 00:00:00

abstract：:Transforming growth factor beta (TGFbeta) is a critical immunosuppressive cytokine that inhibits the cell-mediated immune responses partly via inhibition of immunostimulatory cytokine production from T cells, NK cells, and macrophages. Here we investigated the effect of TGFbeta on NK cell activation induced by interle...

journal_title：Biochemical and biophysical research communications

authors： Hayashi H,Inoue Y,Tsutsui H,Okamura H,Nakanishi K,Onozaki K

更新日期：2003-01-24 00:00:00

abstract：:The sarcoplasmic potassium concentration of a suspension of rat ventricular myocytes, prepared by collagenase-induced disruption of the myocardial mass, was determined by a null-point technique. Addition of digitonin resulted in a release of potassium from the cells which was interpreted as a flux from the sarcoplasm....

journal_title：Biochemical and biophysical research communications

authors： Fry CH,Ward JP,Twist VW,Powell T

更新日期：1986-05-29 00:00:00

abstract：:Human lymphocyte growth response to mitogen was examined in vitro under different conditions to monitor aspects of carbohydrate utilization in three groups: obese nondiabetic, obese/NIDDM, and normal-weight individuals. Although lymphocyte growth capacity in minimal medium for these three groups was found to be simila...

journal_title：Biochemical and biophysical research communications

authors： Tu KY,Matthews R,Topek NH,Matthews KS

更新日期：1994-07-29 00:00:00

abstract：:Our previous study on the dynamic transcriptomes activated during human erythropoiesis suggested that transcription factor forkhead box O3 (FOXO3) possibly plays a role in erythroid differentiation. Functional studies in human cell line TF-1 indicated that FOXO3 knockdown repressed erythropoietin (EPO)-induced erythro...

journal_title：Biochemical and biophysical research communications

authors： Wang H,Li Y,Wang S,Zhang Q,Zheng J,Yang Y,Qi H,Qu H,Zhang Z,Liu F,Fang X

更新日期：2015-05-15 00:00:00

abstract：:Protein kinase C (PKC) is the receptor for tumor promoting phorbol esters, which are potent activators of conventional and novel PKCs, but persistent treatment with phorbol esters leads to downregulation of these PKCs. However, PKCη, a novel PKC isozyme, resists downregulation by tumor-promoting phorbol esters, but li...

journal_title：Biochemical and biophysical research communications

authors： Pal D,Outram SP,Basu A

更新日期：2012-09-07 00:00:00

abstract：:Butein, a plant polyphenol, was shown to be a specific protein tyrosine kinase inhibitor. This compound inhibited not only the epidermal growth factor (EGF)-stimulated auto-phosphotyrosine level of EGF receptor in HepG2 cells but also tyrosine-specific protein kinase activities of EGF receptor (IC50 = 65 microM) and p...

journal_title：Biochemical and biophysical research communications

authors： Yang EB,Zhang K,Cheng LY,Mack P

更新日期：1998-04-17 00:00:00

abstract：BACKGROUND:Cell fusion is a phenomenon that is observed in various tissues in vivo, resulting in acquisition of physiological functions such as liver regeneration. Fused cells such as hybridomas have also been produced artificially in vitro. Furthermore, it has been reported that cellular reprogramming can be induced b...

journal_title：Biochemical and biophysical research communications

authors： Imai H,Kusakabe KT,Kiso Y,Hattori S,Kai C,Ono E,Kano K

更新日期：2020-01-01 00:00:00

abstract：:Seleno compounds such as selenocystamine and seleno-D, L-cystine were found to catalyze the decomposition of S-nitrosothiols (e.g. S-nitroso-glutathione and S-nitroso-N-acetyl-D, L-penicillamine) in the presence of different thiols (e.g. glutathione, N-acetyl-D-penicillamine and 2-mercaptoethanol), and liberate nitric...

journal_title：Biochemical and biophysical research communications

authors： Hou Y,Guo Z,Li J,Wang PG

更新日期：1996-11-01 00:00:00

abstract：:Monomethylethanolamine (1 mM) and dimethylethanolamine (1 mM) stimulated DNA synthesis 10- and 15-fold, respectively, in NIH 3T3 fibroblasts. In addition, simultaneous treatments with insulin (500 nM) and methylated ethanolamine analogues (1 mM or less) resulted in synergistic activation of DNA synthesis. The order of...

journal_title：Biochemical and biophysical research communications

authors： Kiss Z,Crilly KS,Anderson WB

更新日期：1996-03-07 00:00:00

abstract：:15(S)-15-methyl-prostaglandin E1 and prostaglandin I2 rapidly and reversibly inhibit formyl-methionyl-leucyl-phenylalanine induced superoxide production by human neutrophils. In contrast, 15(S)-15-methyl-prostaglandin E1 and prostaglandin I2 did not alter the rate or the total amount of superoxide production by human ...

journal_title：Biochemical and biophysical research communications

authors： Fantone JC,Kinnes DA

更新日期：1983-06-15 00:00:00