A [2Fe-2S] protein from the hyperthermophilic bacterium Aquifex aeolicus.

abstract：:It has been shown that adipose tissue hyperplasia (increased adipocyte number or adipogenesis) has beneficial effects on metabolic health. The aim of the present study was to determine whether phytol could modulate hyperplasia/adipogenesis and glucose homeostasis, and to explore the underlying mechanisms in mice fed h...

journal_title：Biochemical and biophysical research communications

authors： Wang J,Hu X,Ai W,Zhang F,Yang K,Wang L,Zhu X,Gao P,Shu G,Jiang Q,Wang S

更新日期：2017-08-05 00:00:00

abstract：:Regarding the molecular mechanism of dynamin in receptor-mediated endocytosis, GTPase activity of dynamin has been thought to have a critical role in endocytic vesicle internalization. However, a recent report suggested that GTP-binding to dynamin itself activates the dynamin to recruit molecular machinery necessary f...

journal_title：Biochemical and biophysical research communications

authors： Jeong MJ,Yoo J,Lee SS,Lee KI,Cho A,Kwon BM,Moon MJ,Park YM,Han MY

更新日期：2001-04-27 00:00:00

abstract：:Pentoxyresorufin O-depentylase activity, mainly associated with phenobarbital-inducible cytochrome P450IIB1 (designated CYP2B1), was increased after a single treatment of pyridine (250 mg/kg, i.p.), and further increased by repeated treatments for 5 days. The catalytic activity and immunoreactive protein of CYP2B reco...

journal_title：Biochemical and biophysical research communications

authors： Park KS,Sohn DH,Veech RL,Song BJ

更新日期：1992-06-15 00:00:00

abstract：:Colorectal carcinoma (CRC) is one of the most frequently diagnosed cancers and the leading cause of cancer-related death for both men and women. Recent studies have revealed that a small sub-population of cancer cells, termed cancer stem-like cells (CSCs)/cancer-initiating cells (CICs), are endowed with tumor-initiati...

journal_title：Biochemical and biophysical research communications

authors： Wang L,Hirohashi Y,Ogawa T,Shen M,Takeda R,Murai A,Yamamoto E,Kubo T,Nakatsugawa M,Kanaseki T,Tsukahara T,Nishidate T,Okita K,Kutomi G,Sato N,Takemasa I,Torigoe T

更新日期：2017-04-29 00:00:00

abstract：:Hepatocytes isolated from normal adult rats were maintained at sub-confluent density in a defined medium in primary culture. In control cultures with added epidermal growth factor and low concentrations of dexamethasone, the rate of DNA synthesis was initially low but increased after about 30 hours in culture. Additio...

journal_title：Biochemical and biophysical research communications

authors： Edwards AM,Lucas CM

更新日期：1985-08-30 00:00:00

abstract：:Recent studies have demonstrated homology between bone-derived growth factor and beta 2 microglobulin. We have shown that beta 2 microglobulin has proliferative actions on human bone-derived cells in vitro and that these cells also show immunogenicity for beta 2 microglobulin. beta 2 microglobulin stimulated the incor...

journal_title：Biochemical and biophysical research communications

authors： Evans DB,Thavarajah M,Kanis JA

更新日期：1991-03-29 00:00:00

abstract：:In the present study, we demonstrated that there is a direct relationship between scratching behaviors induced by itch and functional changes in the brain reward system. Using a conditional place preference test, the rewarding effect was clearly evoked by scratching under both acute and chronic itch stimuli. The induc...

journal_title：Biochemical and biophysical research communications

authors： Setsu T,Hamada Y,Oikawa D,Mori T,Ishiuji Y,Sato D,Narita M,Miyazaki S,Furuta E,Suda Y,Sakai H,Ochiya T,Tezuka H,Iseki M,Inada E,Yamanaka A,Kuzumaki N,Narita M

更新日期：2021-01-01 00:00:00

abstract：:Glucagon-like peptide-1 (GLP-1) receptor agonists have been used to treat type 2 diabetic patients and shown to reduce food intake and body weight. The anorexigenic effects of GLP-1 and GLP-1 receptor agonists are thought to be mediated primarily via the hypothalamic paraventricular nucleus (PVN). GLP-1, an intestinal...

journal_title：Biochemical and biophysical research communications

authors： Katsurada K,Maejima Y,Nakata M,Kodaira M,Suyama S,Iwasaki Y,Kario K,Yada T

更新日期：2014-08-22 00:00:00

abstract：:Glutamate receptor delta2 (GluD2) is selectively expressed on the postsynaptic spines at parallel-fiber (PF)-Purkinje neuron (PN) synapses. GluD2 knockout mice show a reduced number of PF-PN synapses, suggesting that GluD2 is involved in synapse formation. Recent studies revealed that GluD2 induces presynaptic differe...

journal_title：Biochemical and biophysical research communications

authors： Kuroyanagi T,Hirano T

更新日期：2010-07-30 00:00:00

abstract：:As a model host, the nematode Caenorhabditis elegans has been used for studying unknown pathogen-host interactions and identifying novel virulence factors in bacterial pathogens. Among the bacterial pathogens that can induce death of C. elegans is enterohemorrhagic Escherichia coli (EHEC) O157:H7, a major serotype of ...

journal_title：Biochemical and biophysical research communications

authors： Youn M,Lee KM,Kim SH,Lim J,Yoon JW,Park S

更新日期：2013-07-05 00:00:00

abstract：:Autophagy is a biological recycling process via the self-digestion of organelles, proteins, and lipids for energy-consuming differentiation and homeostasis. The Golgi serves as a donor of the double-membraned phagophore for autophagosome assembly. In addition, recent studies have demonstrated that pulmonary and hepati...

journal_title：Biochemical and biophysical research communications

authors： Park S,Kim S,Kim MJ,Hong Y,Lee AY,Lee H,Tran Q,Kim M,Cho H,Park J,Kim KP,Park J,Cho MH

更新日期：2018-01-01 00:00:00

abstract：:Bone is one of the essential target tissues of growth hormone (GH). In bone remodeling, cell-matrix attachment is important where focal adhesion kinase (FAK) is involved. FAK plays a central role in determining the shape and motility of cells in response to the extracellular matrix stimuli. In the present study, we ha...

journal_title：Biochemical and biophysical research communications

authors： Takahashi MO,Takahashi Y,Iida K,Okimura Y,Kaji H,Abe H,Chihara K

更新日期：1999-09-16 00:00:00

abstract：:Sulfate plays an essential role in human growth and development. Here, we characterized the functional properties of the human Na(+)-sulfate cotransporter (hNaS2), determined its tissue distribution, and identified its gene (SLC13A4) structure. Expression of hNaS2 protein in Xenopus oocytes led to a Na(+)-dependent tr...

journal_title：Biochemical and biophysical research communications

authors： Markovich D,Regeer RR,Kunzelmann K,Dawson PA

更新日期：2005-01-28 00:00:00

abstract：:Oxytocin binding activity of myoepithelial cell membranes from mammary tissue was measured under a variety of different experimental conditions. Mammary tissue from non-lactating rats bound oxytocin with a Kd of 9.2 +/- 1.6 nM (+/- S.E.) and indicates that receptors are retained by the myoepithelial cells in a non-lac...

journal_title：Biochemical and biophysical research communications

authors： Ruberti A,Olins GM,Eakle KA,Bremel RD

更新日期：1983-04-29 00:00:00

abstract：:The maximal activity of the enzymes hexokinase and 6-phosphofructokinase were measured in interscapular brown adipose tissue during ageing in the rat. The activity of these glycolytic enzymes increased markedly during the suckling-weaning transition (20-22 days of age), but from 30 to 100 days of age the activities pe...

journal_title：Biochemical and biophysical research communications

authors： Simpson ML,Cooney GJ,Caterson ID,Newsholme EA

更新日期：1986-10-15 00:00:00

abstract：:We have constructed two phagemid vectors containing the gene coding for human Prostate Specific Antigen (PSA) translationally fused to a pelB signal sequence and minor coat protein III of phage fd leading to phage particles that carry PSA on their tips. Phages were characterized by Western blotting and by panning, usi...

journal_title：Biochemical and biophysical research communications

authors： Eerola R,Saviranta P,Lilja H,Pettersson K,Lövgren T,Karp M

更新日期：1994-05-16 00:00:00

abstract：:It has been shown that MDM2 inhibits the transcriptional and pro-apoptotic activities of p73 but does not promote its proteasomal degradation. In this study, we found that MDM2 indirectly induces the degradation of p73 through the interaction with Itch in HeLa cells. During adriamycin (ADR)-mediated apoptosis, p53 and...

journal_title：Biochemical and biophysical research communications

authors： Kubo N,Okoshi R,Nakashima K,Shimozato O,Nakagawara A,Ozaki T

更新日期：2010-12-17 00:00:00

abstract：:Tumor necrosis factor (TNF)alpha is considered to play a key pathogenetic role in inflammatory bowel diseases. In this study we analyzed the mechanisms by which TNFalpha induces intestinal epithelial cell apoptosis. TNFalpha alone, and more potently in combination with IFNgamma, induced a high degree of IEC-6 cell apo...

journal_title：Biochemical and biophysical research communications

authors： Ruemmele FM,Dionne S,Levy E,Seidman EG

更新日期：1999-06-24 00:00:00

abstract：:We report that the human 1,25-dihydroxyvitamin D3 receptor is an efficient substrate for cAMP-dependent protein kinase, in vitro. This phosphorylation reaction is rapid and neither dependent upon nor significantly affected by the presence of the 1,25-dihydroxyvitamin D3 ligand. Preliminary mapping experiments utilizin...

journal_title：Biochemical and biophysical research communications

authors： Jurutka PW,Hsieh JC,Haussler MR

更新日期：1993-03-31 00:00:00

abstract：:The phosphatidylinositol-3-kinase (PI3K)/AKT axis and the Nuclear Factor kappa B (NFκB) pathway play critical roles in macrophage survival. In cells other than macrophages proper operation of those two pathways requires Ca²(+) influx into the cell, but if that is the case in macrophages remains unexplored. In the pres...

journal_title：Biochemical and biophysical research communications

authors： Tano JY,Vazquez G

更新日期：2011-04-08 00:00:00

abstract：:Embryo development proceeds under strict temporal control and an embryonic molecular clock (EC), evidenced by cyclic gene expression, is operating during somite formation and limb development, providing temporal information to precursor cells. In somite precursor cells, EC gene expression and periodicity depends on Re...

journal_title：Biochemical and biophysical research communications

authors： Sheeba CJ,Palmeirim I,Andrade RP

更新日期：2012-07-13 00:00:00

abstract：:XAF1 (XIAP-associated factor 1) binds to XIAP and blocks its anti-apoptotic activity. It has been reported that XAF1 is mainly expressed in normal tissues but is missing or present at low levels in most cancer cell lines, which implies a tumor-suppressing function. In the present study we describe the identification o...

journal_title：Biochemical and biophysical research communications

authors： Yin W,Cheepala S,Clifford JL

更新日期：2006-01-27 00:00:00

abstract：:Interleukin 6 is a cytokine with growth and differentiation activities on a number of cell types. Human articular chondrocytes produce interleukin 6 and this production appears to be constitutive but can be stimulated in a dose-dependent manner by interleukin 1. Other stimulators of interleukin 6 production in chondro...

journal_title：Biochemical and biophysical research communications

authors： Bunning RA,Russell RG,Van Damme J

更新日期：1990-02-14 00:00:00

abstract：:Plasma membrane fractions from mouse livers were examined for the presence of growth regulatory peptides. Both growth inhibitory and growth stimulatory factors were found on these membranes. The growth inhibitory component could be enriched by extractions with both dimethylmaleic anhydride and octylglucoside. The grow...

journal_title：Biochemical and biophysical research communications

authors： Lieberman MA

更新日期：1984-05-16 00:00:00

abstract：:Cells from patients with acute myeloid leukaemia (AML) contain an abnormally high UDP-GlcNAc: Gal beta 1-3GalNAc-R (GlcNAc to GalNAc) beta 6-N-acetylglucosaminyltransferase (core 2 beta 6-Gn-T) activity. Upon UV irradiation at 350 nm, the substrate Gal beta 1-3GalNAc alpha-p-nitrophenyl acted as an effective inhibitor...

journal_title：Biochemical and biophysical research communications

authors： Toki D,Granovsky MA,Reck F,Kuhns W,Baker MA,Matta KL,Brockhausen I

更新日期：1994-01-28 00:00:00

abstract：:The cell surface of Candida albicans is enriched with highly glycosylated mannoproteins that are involved in the interaction with host tissues. N- and O-glycosylation are post-translational modifications that initiate in the endoplasmic reticulum, and finalize in the Golgi. The KRE2/MNT1 family encode a set of multifu...

journal_title：Biochemical and biophysical research communications

authors： Díaz-Jiménez DF,Mora-Montes HM,Hernández-Cervantes A,Luna-Arias JP,Gow NA,Flores-Carreón A

更新日期：2012-03-02 00:00:00

abstract：:Oxidative stress contributes to tissue injury and cell death during the development of various diseases. The present study aims at investigating whether oxidative stress triggered by the exposure to hydrogen peroxide (H(2)O(2)) can induce apoptosis of induced pluripotent stem cells (iPS cells) in a mechanism mediated ...

journal_title：Biochemical and biophysical research communications

authors： Li Y,Shelat H,Geng YJ

更新日期：2012-10-05 00:00:00

abstract：:Thrombin induced tyrosine phosphorylation of 41-kDa and 43-kDa mitogen-activated protein (MAP) kinases in human platelets which was detectable at 1 min and peaked at 2 min after thrombin stimulation as assessed by immunoprecipitation and immunoblotting. The kinase activity, measured by phosphorylation of myelin basic ...

journal_title：Biochemical and biophysical research communications

authors： Nakashima S,Chatani Y,Nakamura M,Miyoshi N,Kohno M,Nozawa Y

更新日期：1994-01-28 00:00:00

abstract：:The phenothiazine antipsychotic drug chlorpromazine, a potent calmodulin antagonist, inhibited human natural killer cell-mediated cytotoxicity in a dose-dependent manner. This inhibition of natural killer cell activity was not due to interference with conjugate formation, nor was it due to toxicity to the natural kill...

journal_title：Biochemical and biophysical research communications

authors： Steele TA,Brahmi Z

更新日期：1988-09-15 00:00:00

abstract：:Osteoarthritis (OA) is the most common form of joint disease. The development of inflammation have been considered to play a key role during the progression of OA. Regulatory pathways are known to play crucial roles in many pathogenic processes. Thus, deciphering these risk regulatory pathways is critical for elucidat...

journal_title：Biochemical and biophysical research communications

authors： Song Z,Zhang C,He L,Sui Y,Lin X,Pan J

更新日期：2018-06-12 00:00:00