Inhibition of UDP-GlcNAc:Gal beta 1-3GalNAc-R (GlcNAc to GalNAc) beta 6-N-acetylglucosaminyltransferase from acute myeloid leukaemia cells by photoreactive nitrophenyl substrate derivatives.

abstract：:Resveratrol (trans-3,5,4'-trihydroxystilbene), a polyphenolic compound found largely in the skins of red grapes, has been used as a nutritional supplement or an investigational new drug for prevention of cardiovascular diseases. Previous reports showed that resveratrol had a protective effect against oxidative agent-i...

journal_title：Biochemical and biophysical research communications

authors： Leong CW,Wong CH,Lao SC,Leong EC,Lao IF,Law PT,Fung KP,Tsang KS,Waye MM,Tsui SK,Wang YT,Lee SM

更新日期：2007-08-17 00:00:00

abstract：:The proB proA operons (which are blocked by the feedback inhibition of proline production) of Escherichia coli wild type or with the mutation proBosm, blocking feedback inhibition effect of proline production, were cloned in a broad host range shuttle vector pVA 12-2. The hybrid plasmids pLVA(proB+A+) and pNSA(proBosm...

journal_title：Biochemical and biophysical research communications

authors： Neumivakin LV,Solovjev VP,Sokhansanj A,Tilba VA,Moseiko NA,Shachbasian RV,Piruzian ES

更新日期：1995-12-26 00:00:00

abstract：:Arctigenin (ARC), a phenylpropanoid dibenzylbutyrolactone lignan derived from Arctium lappa L, has been reported to protect against cerebral ischemia injury in rats, but the underlying mechanism is unclear. In this study, we investigated whether ARC ameliorated ischemic stroke by inhibiting NLRP3 inflammasome-derived ...

journal_title：Biochemical and biophysical research communications

authors： Zhang S,Jiang L,Che F,Lu Y,Xie Z,Wang H

更新日期：2017-11-04 00:00:00

abstract：:Methylation-specific PCR (MSP) is frequently used to distinguish methylated alleles in the genome. Sequences that have been incompletely converted during bisulfite treatment are frequently co-amplified during MSP. For accurate MSP, it is important to detect methylated sequences in a background of unconverted DNA with ...

journal_title：Biochemical and biophysical research communications

authors： Sasaki M,Anast J,Bassett W,Kawakami T,Sakuragi N,Dahiya R

更新日期：2003-09-19 00:00:00

abstract：:XAF1 (XIAP-associated factor 1) binds to XIAP and blocks its anti-apoptotic activity. It has been reported that XAF1 is mainly expressed in normal tissues but is missing or present at low levels in most cancer cell lines, which implies a tumor-suppressing function. In the present study we describe the identification o...

journal_title：Biochemical and biophysical research communications

authors： Yin W,Cheepala S,Clifford JL

更新日期：2006-01-27 00:00:00

abstract：:In the present studies, cAMP, a secondary messenger historically viewed as a negative mediator of immune responses, was demonstrated to possess immunoenhancing activity at low concentrations. In parallel experiments the adenylate cyclase inhibitor, 2',3'-dideoxyadenosine, produced a marked inhibition of humoral and pr...

journal_title：Biochemical and biophysical research communications

authors： Koh WS,Yang KH,Kaminski NE

更新日期：1995-01-17 00:00:00

abstract：:The discovery of small molecule kinase inhibitors for use as drugs is a promising approach for the treatment of cancer and other diseases, but the discovery of highly specific agents is challenging because over 850 kinases are expressed in mammalian cells. Systematic modification of the 4-anilino functionality of a se...

journal_title：Biochemical and biophysical research communications

authors： Bhattacharya SK,Cox ED,Kath JC,Mathiowetz AM,Morris J,Moyer JD,Pustilnik LR,Rafidi K,Richter DT,Su C,Wessel MD

更新日期：2003-07-25 00:00:00

abstract：:The purpose of this study was to examine whether mechanical tensile forces affect estrogen regulation of collagen synthesis of anterior cruciate ligament fibroblasts at the mRNA level. Estrogen was studied at three physiologic levels, 10(-11), 10(-10), and 10(-9)M. The results revealed that estrogen alone stimulated T...

journal_title：Biochemical and biophysical research communications

authors： Lee CY,Smith CL,Zhang X,Hsu HC,Wang DY,Luo ZP

更新日期：2004-05-14 00:00:00

abstract：:Fiber X-ray diffraction and measurement of fibre dimensions yield information about the effects of a mechanical tension on hydration of DNA in fibres. At a given relative humidity, the mechanical tension changes the DNA conformation but does not modify the number of water molecules associated to a nucleotide. The numb...

journal_title：Biochemical and biophysical research communications

authors： Harmouchi M,Albiser G,Premilat S

更新日期：1992-10-15 00:00:00

abstract：:MH1C1 rat hepatoma cells express the alpha isoenzyme as the only phorbol-ester sensitive isoform of protein kinase C (PKC). In this cell line, phorbol 12-myristate 13-acetate (PMA) induced a marked, dose-dependent growth inhibition. The administration of the PKC inhibitor staurosporine was able to mimic the effect of ...

journal_title：Biochemical and biophysical research communications

authors： Perletti GP,Smeraldi C,Porro D,Piccinini F

更新日期：1994-12-30 00:00:00

abstract：:The Monte Carlo method has been used to simulate the equilibrium properties of a planar array of 94 saturated lipid chains and one monomer of Gramicidin A. Chains are free to move laterally in the layer plane and to change conformation via gauche rotations and long axis rotations in a continuum. All non-hydrogen atoms...

journal_title：Biochemical and biophysical research communications

authors： Xing J,Scott HL

更新日期：1989-11-30 00:00:00

abstract：:Analysis of a 67 kDa lipid-dependent Ca(2+)-binding protein from avian matrix vesicles revealed amino acid sequences homologous to mammalian annexin VI. PCR methods were used to identify a clone from an avian cDNA library that contained a full length copy of the 67-kDa annexin cDNA. This was restriction mapped, subclo...

journal_title：Biochemical and biophysical research communications

authors： Cao X,Genge BR,Wu LN,Buzzi WR,Showman RM,Wuthier RE

更新日期：1993-12-15 00:00:00

abstract：:Glycosylation of endothelin (ET) receptors was found to occur in rat cerebellar and atrial membranes. Specifically, we investigated whether the ETA and ETB receptor subtypes differed in their sensitivity to deglycosylation treatment and whether the two affinity states (nanomolar and picomolar) observed in each recepto...

journal_title：Biochemical and biophysical research communications

authors： Shraga-Levine Z,Sokolovsky M

更新日期：1998-05-19 00:00:00

abstract：:Microglia are central nervous system-resident immune cells that play a crucial role in brain development by interacting with neural precursor cells (NPCs). It has been reported that microglia regulate the number of NPC by phagocytosis, inducing apoptosis, and promoting proliferation. Microglia surrounding the subventr...

journal_title：Biochemical and biophysical research communications

authors： Yamamiya M,Tanabe S,Muramatsu R

更新日期：2019-06-11 00:00:00

abstract：BACKGROUND:- Tadalafil, a long-acting phosphodiesterase 5 (PDE5) inhibitor, alleviates preeclampsia (PE), and decreases the fetal and infant deaths associated with fetal growth restriction (FGR) in phase II clinical trial. Recently, we demonstrated that tadalafil alleviates FGR and hypertension in the dams with PE indu...

journal_title：Biochemical and biophysical research communications

authors： Sekimoto A,Tanaka K,Hashizume Y,Sato E,Sato H,Ikeda T,Takahashi N

更新日期：2020-01-15 00:00:00

abstract：:Partially purified preparations of O6-alkylguanine-DNA alkyltransferase from rat liver and E. coli were tested for their ability to repair O4-methylthymine in a methylated poly(dT) X poly(dA) substrate. The bacterial preparation readily carried out this reaction, but no loss of O4-methylthymine was obtained with the r...

journal_title：Biochemical and biophysical research communications

authors： Dolan ME,Scicchitano D,Singer B,Pegg AE

更新日期：1984-08-30 00:00:00

abstract：:The rate limiting step in 5-fluorouracil catabolism is catalyzed by the enzyme dihydropyrimidine dehydrogenase. Since degradation of 5-fluorouracil decreases its efficacy in chemotherapy, the inhibition of its catabolism is a promising tool. We investigated the formation of micronuclei in vitro in mouse L5178Y cells. ...

journal_title：Biochemical and biophysical research communications

authors： Stopper H,Kühnel A,Podschun B

更新日期：1994-09-15 00:00:00

abstract：:BA1544 from Bacillus anthracis was previously annotated as a transcription factor for the gene cluster ba1554 - ba1558, but has not been experimentally characterized. B. anthracis is an obligate pathogen causing fatal inhalational anthrax, and BA1544 is absolutely conserved in Bacillus species, including Bacillus cere...

journal_title：Biochemical and biophysical research communications

authors： Kim MI,Hong M

更新日期：2016-03-25 00:00:00

abstract：:A novel inhibitory receptor of immunoglobin superfamily (IgSF), IgSF member 13 (IgSF13), has been identified from human dendritic cells (DC). IgSF13 is a type I transmembrane protein containing an N-terminal signal peptide, a extracellular region with a single Ig V-like domain, a transmembrane region, and a cytoplasmi...

journal_title：Biochemical and biophysical research communications

authors： Sui L,Li N,Liu Q,Zhang W,Wan T,Wang B,Luo K,Sun H,Cao X

更新日期：2004-07-02 00:00:00

abstract：:Inositol 1,2,3,5,6-pentakisphosphate (Ins(1,2,3,5,6)P5) 5-phosphatase present in fetal calf thymus has been partially purified. This enzyme was inhibited dose-dependently by different thiol modifiers like N-ethylmaleimide (NEM), p-chloromercuribenzene sulfonate (PCMBS), diamide, and phenylarsine oxide (PAO). The inhib...

journal_title：Biochemical and biophysical research communications

authors： Bandyopadhyay U,Kaiser T,Rudolf MT,Schultz C,Guse AH,Mayr GW

更新日期：1997-11-07 00:00:00

abstract：:Huntington's disease (HD) is caused by mutations that expand a polyglutamine region in the amino-terminal domain of Huntingtin (Htt), leading to the accumulation of intracellular inclusions and progressive neurodegeneration. Recent reports indicate the engagement of endoplasmic reticulum (ER) stress responses in human...

journal_title：Biochemical and biophysical research communications

authors： Zuleta A,Vidal RL,Armentano D,Parsons G,Hetz C

更新日期：2012-04-13 00:00:00

abstract：:Isolated rat hepatocytes exposed to CCl4 showed a dramatic decrease in [32P] incorporation into proteins which was evident as early as 5 min after the haloalkane addition. DEAE cellulose separation of protein kinases present in both particulated and cytosolic fractions of hepatocytes revealed that only the calcium and...

journal_title：Biochemical and biophysical research communications

authors： Poli G,Albano E,Dianzani MU,Melloni E,Pontremoli S,Marinari UM,Pronzato MA,Cottalasso D

更新日期：1988-06-16 00:00:00

abstract：:Vibrio cholerae cytolysin (VCC) is a membrane-damaging beta-barrel pore-forming toxin (beta-PFT). VCC causes permeabilization of the target membranes by forming transmembrane oligomeric beta-barrel pores. Oligomerization is a key step in the mode of action of any beta-PFT, including that of VCC. Earlier studies have i...

journal_title：Biochemical and biophysical research communications

authors： Rai AK,Chattopadhyay K

更新日期：2016-06-03 00:00:00

abstract：:The fau gene is the cellular homolog of the fox sequence in the Finkel-Biskis-Reilly Murine Sarcoma Virus (FBR-MuSV). This virus acquired the fau sequence in its reversed transcriptional orientation. Human and mouse fau cDNA's were identified and both encode a new protein of 133 AA. We show that fau (for FBR-MuSV asso...

journal_title：Biochemical and biophysical research communications

authors： Kas K,Michiels L,Merregaert J

更新日期：1992-09-16 00:00:00

abstract：:Pyruvate carboxylase (PC) catalyzes the first committed step in gluconeogenesis. Here we investigated the effect of various hormones including cAMP, dexamethasone and insulin on the abundance of PC mRNA in the human hepatocyte cell line, HepG2. Treatment of HepG2 cells with 1 microM of glucagon increased the expressio...

journal_title：Biochemical and biophysical research communications

authors： Thonpho A,Sereeruk C,Rojvirat P,Jitrapakdee S

更新日期：2010-03-19 00:00:00

abstract：:We screened various isoprenoids to search for inducers of apoptosis-like cell death ("apoptosis") in the shoot primordia of Matricaria chamomilla and found that geraniol has the most potent apoptosis-inducing activity among terpenoids, as judged from DNA fragmentation in the cells. The apoptosis-inducing activity of g...

journal_title：Biochemical and biophysical research communications

authors： Izumi S,Takashima O,Hirata T

更新日期：1999-06-16 00:00:00

abstract：:miR-183 cluster, composed of miR-183/-96/-182 genes, is highly expressed in the adult retina, particularly in photoreceptors. It involves in development, maturation and normal function of neuroretina. Ectopic overexpression of miR-183/-96/-182 genes was performed to assess reprogramming of hRPE cells. They were amplif...

journal_title：Biochemical and biophysical research communications

authors： Davari M,Soheili ZS,Samiei S,Sharifi Z,Pirmardan ER

更新日期：2017-01-29 00:00:00

abstract：:In this report, we describe the expression and function of human Sp5, a member of the Sp family of zinc finger transcription factors. Like other family members, the Sp5 protein contains a Cys2His2 zinc finger DNA binding domain at the C-terminus. Our experiments employing Gal4-Sp5 fusion proteins reveal multiple trans...

journal_title：Biochemical and biophysical research communications

authors： Chen Y,Guo Y,Ge X,Itoh H,Watanabe A,Fujiwara T,Kodama T,Aburatani H

更新日期：2006-02-17 00:00:00

abstract：:Calpain was generally believed to exist and function only in the cytoplasm. However, m-calpain has now been detected in the extracellular spaces of some kinds of tissue. In this study, we demonstrated the existence of m-calpain in the medium surrounding MC3T3-E1 cultures, and its activity by zymography. At the same ti...

journal_title：Biochemical and biophysical research communications

authors： Nishihara H,Nakagawa Y,Ishikawa H,Ohba M,Shimizu K,Nakamura T

更新日期：2001-07-20 00:00:00

abstract：:At an early stage of apoptosis, Jurkat cells transiently become susceptible to binding and phagocytosis by macrophages through the polylactosamine-type carbohydrate chains of CD43 [J. Biol. Chem. 279 (2004) 5967]. Susceptibility of apoptotic Jurkat cells to macrophage recognition was studied over an extended time rang...

journal_title：Biochemical and biophysical research communications

authors： Yamanaka M,Eda S,Beppu M

更新日期：2005-03-04 00:00:00