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Carbon tetrachloride-induced inhibition of protein kinase C in isolated rat hepatocytes.

Abstract：

:Isolated rat hepatocytes exposed to CCl4 showed a dramatic decrease in [32P] incorporation into proteins which was evident as early as 5 min after the haloalkane addition. DEAE cellulose separation of protein kinases present in both particulated and cytosolic fractions of hepatocytes revealed that only the calcium and phospholipids dependent protein kinase C was affected by the treatment with CCl4, while kinases not requiring these factors for their activity were unmodified. Several 4-hydroxyunsaturated aldehydes known to be produced during CCl4-stimulated lipid peroxidation were found to inhibit protein kinase C at micromolar concentrations, suggesting the possibility that peroxidative events might be responsible for the impairment of protein kinase C during CCl4 intoxication.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Poli G,Albano E,Dianzani MU,Melloni E,Pontremoli S,Marinari UM,Pronzato MA,Cottalasso D

doi

10.1016/s0006-291x(88)81136-7

subject

Has Abstract

pub_date

1988-06-16 00:00:00

pages

591-7

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(88)81136-7

journal_volume

153

pub_type

杂志文章

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