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Biotransformation of 1-nitropyrene and 2-nitrofluorene to novel metabolites, the corresponding formylamino compounds, in animal bodies.

Abstract：

:The present study provides the first evidence that nitropolycyclic aromatic hydrocarbons such as 1-nitropyrene and 2-nitrofluorene are metabolized to the corresponding formylamino compounds in animal bodies. The study shows that the formation of such novel metabolites, 1-formylaminopyrene and 2-formylaminofluorene, is due to N-formylation of the nitroreduction products, 1-aminopyrene and 2-aminofluorene, by liver formamidase in the presence of N-formyl-L-kynurenine.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Tatsumi K,Amano H

doi

10.1016/0006-291x(87)90284-1

subject

Has Abstract

pub_date

1987-01-30 00:00:00

pages

376-82

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(87)90284-1

journal_volume

142

pub_type

杂志文章

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