Correlation between up-regulation of lymphokine mRNA and down-regulation of TcR, CD4, CD8 and lck mRNA as shown by the effect of CsA on activated T lymphocytes.

abstract：:To evaluate the immunomodulatory effects of histamine in vivo, we analyzed an experimental syngenic tumor model using a colon adenocarcinoma cell line, CT-26, in Balb/c mice. In this model, distinct tumor growth was observed around 6 days after inoculation. Daily administration of cimetidine (0.12 mg/kg/day) significa...

journal_title：Biochemical and biophysical research communications

authors： Takahashi K,Tanaka S,Ichikawa A

更新日期：2001-03-01 00:00:00

abstract：:The chemical industry has come under increasing pressure to make chemical production more eco-friendly and independent to fossil resources. The development of industrial processes based on micro-organisms can especially help to eliminate the use or the generation of hazardous substances and can support the transition ...

journal_title：Biochemical and biophysical research communications

authors： Saibi W,Abdeljalil S,Masmoudi K,Gargouri A

更新日期：2012-09-28 00:00:00

abstract：:Thioproline (Thiazolidine-4-carboxylic acid) and proline were nitrosated by stimulated mouse macrophages in vitro. A macrophage cell line (J774.1, 1.0 x 10(6)/well, 1 ml) was incubated with Escherichia coli lipopolysaccharide, interferon-gamma and thioproline (5 mM) or proline (5 mM). After 72 hr incubation at 37 degr...

journal_title：Biochemical and biophysical research communications

authors： Miwa M,Tsuda M,Kurashima Y,Hara H,Tanaka Y,Shinohara K

更新日期：1989-03-15 00:00:00

abstract：:Liver regeneration is regulated by several factors. Among these extracellular matrix plays a crucial role in the restoration of normal structure. Proteoglycans are major components of extracellular matrix and they are able to bind growth factors implicated in liver growth. We studied syndecan, perlecan, fibroglycan, a...

journal_title：Biochemical and biophysical research communications

authors： Gallai M,Sebestyén A,Nagy P,Kovalszky I,Onody T,Thorgeirsson SS

更新日期：1996-11-21 00:00:00

abstract：:Various gene delivery systems have been widely studied for the acute spinal cord injury (SCI) treatment. In the present study, a novel type of brain-derived neurotrophic factor (BDNF)-loaded cationic nanobubbles (CNBs) conjugated with MAP-2 antibody (mAbMAP-2/BDNF/CNBs) was prepared to provide low-intensity focused ul...

journal_title：Biochemical and biophysical research communications

authors： Song Z,Ye Y,Zhang Z,Shen J,Hu Z,Wang Z,Zheng J

更新日期：2018-02-12 00:00:00

abstract：:In RBL-2H3 rat basophilic leukemia cells, Fc epsilon R1 crosslinking by multivalent antigen stimulates phosphatidylinositol (PI) turnover and Ca2+ influx and causes functional responses that include secretion, membrane ruffling and actin polymerization. Here, we show that the tyrosine kinase inhibitor, genistein, inhi...

journal_title：Biochemical and biophysical research communications

authors： Deanin GG,Martinez AM,Pfeiffer JR,Gardner ME,Oliver JM

更新日期：1991-08-30 00:00:00

abstract：:[2-14C]-trans-2-hexadecenoyl CoA (16:1) and [2-14C]-trans-2-cis-8,11,14-eicosatetraenoyl CoA (20:4) were chemically synthesized and employed as competitive substrates for the liver microsomal trans-2-enoyl CoA reductase component of the fatty acid chain elongation system. Both 7.5 microM and 15 microM 20:4 competitive...

journal_title：Biochemical and biophysical research communications

authors： Nagi MN,Cook L,Prasad MR,Cinti DL

更新日期：1986-10-15 00:00:00

abstract：:During IFN alpha stimulation, p59(fyn) associates with the Type I IFNR-associated Tyk-2 kinase in several human hematopoietic cell lines in vivo. This interaction is direct, and is mediated by the SH2 domain in p59(fyn), as shown by binding studies using glutathione-S-transferase fusion proteins and far western blots....

journal_title：Biochemical and biophysical research communications

authors： Uddin S,Sher DA,Alsayed Y,Pons S,Colamonici OR,Fish EN,White MF,Platanias LC

更新日期：1997-06-09 00:00:00

abstract：:Based on our recent observation that enhanced IL-18 expression positively correlates with malignant skin tumors, such as SCC and melanoma, we examined the possible role of UVB, known to be associated with skin cancer development, in the enhancement of IL-18 production using primary human epidermal keratinocytes and hu...

journal_title：Biochemical and biophysical research communications

authors： Cho D,Seung Kang J,Hoon Park J,Kim YI,Hahm E,Lee J,Yang Y,Jeon J,Song H,Park H,Kim T,Pang S,Kim CW,Il Hwang Y,Jae Lee W

更新日期：2002-10-25 00:00:00

abstract：:Casein kinase II (CKII) activity in colorectal tumours was compared before and after heterotransplantation onto nude mice. The test revealed that the enzyme activity was about two-fold enhanced in the tumours isolated from the nude mice when compared to the respective primary tumours from which they were derived. Immu...

journal_title：Biochemical and biophysical research communications

authors： Seitz G,Münstermann U,Schneider HR,Issinger OG

更新日期：1989-08-30 00:00:00

abstract：:The nucleotide sequence of human Go alpha was determined from a partial human brain cDNA clone and the sequence of the first two 5' coding exons of a human genomic Go alpha clone. Comparison of this sequence with bovine and rat Go alpha shows greater than 90% homology at the nucleotide and deduced amino acid level. Th...

journal_title：Biochemical and biophysical research communications

authors： Lavu S,Clark J,Swarup R,Matsushima K,Paturu K,Moss J,Kung HF

更新日期：1988-01-29 00:00:00

abstract：:Methylglyoxal (MG) (pyruvaldehyde) is an endogenous metabolite which is present in increased concentrations in diabetics and implicated in formation of advanced glycosylation end-products (AGEs) and secondary diabetic complications. Carnosine (beta-alanyl-L-histidine) is normally present in long-lived tissues at conce...

journal_title：Biochemical and biophysical research communications

authors： Hipkiss AR,Chana H

更新日期：1998-07-09 00:00:00

abstract：:The gut-associated lymphoid tissues (GALTs), including Peyer's patches (PPs), cryptopatches (CPs) and isolated lymphoid follicles (ILFs), establish a host-microbe symbiosis by the promotion of immune reactions against gut microbes. Microfold cell inducer (MCi) cells in GALTs are the recently identified mesenchymal cel...

journal_title：Biochemical and biophysical research communications

authors： Nagashima K,Sawa S,Nitta T,Prados A,Koliaraki V,Kollias G,Nakashima T,Takayanagi H

更新日期：2017-11-04 00:00:00

abstract：:Previous investigations in our laboratory demonstrated the existence of an intrinsic mechanism, termed membrane modulation, capable of restoring sensitivity to aspirin treated platelets, resulting in irreversible aggregation in response to arachidonic acid (AA). The mechanism underlying correction of aspirin induced i...

journal_title：Biochemical and biophysical research communications

authors： Rao GH,Radha E,White JG

更新日期：1985-08-30 00:00:00

abstract：:SHPS-1 is a transmembrane protein that binds the protein tyrosine phosphatases SHP-1 and SHP-2 through its cytoplasmic region and is abundantly expressed on dendritic cells and macrophages. Here we show that mice expressing a mutant form of SHPS-1 fail to develop type-II collagen (CII)-induced arthritis (CIA), a model...

journal_title：Biochemical and biophysical research communications

authors： Okuzawa C,Kaneko Y,Murata Y,Miyake A,Saito Y,Okajo J,Tomizawa T,Kaneko Y,Okazawa H,Ohnishi H,Matozaki T,Nojima Y

更新日期：2008-07-04 00:00:00

abstract：:When several DNAs are amplified by PCR in one PCR tube, biased amplification is known to occur because amplification efficiency differs from one DNA to another. Therefore, we conducted PCR in the water in oil-emulsion (W/O emulsion) to examine whether the procedure allows the uniform amplification of several DNAs. In ...

journal_title：Biochemical and biophysical research communications

authors： Hori M,Fukano H,Suzuki Y

更新日期：2007-01-12 00:00:00

abstract：:Chemical modifiers (radiosensitizers) are used in order to increase the efficacy of radiotherapy. The use of Photodynamic Therapy for tumor treatment, especially with Photofrin II, is also known. At present, no chemical modifier has been found to act as a selective radiosensitizer. Experiments using several series of ...

journal_title：Biochemical and biophysical research communications

authors： Kulka U,Schaffer M,Siefert A,Schaffer PM,Olsner A,Kasseb K,Hofstetter A,Dühmke E,Jori G

更新日期：2003-11-07 00:00:00

abstract：:Receptor activator of NF-κB ligand (RANKL) is a member of the TNF superfamily. RANKL increases endothelial permeability and induces angiogenesis, suggesting its critical roles in the vasculature. Despite the evidence implicating RANKL in vascular pathology, its role in ischemic retinopathy has not been previously repo...

journal_title：Biochemical and biophysical research communications

authors： Ock S,Park S,Lee J,Kim J

更新日期：2019-08-20 00:00:00

abstract：:Metallothionein (MT) is believed to be a sensitive and effective "biomarker" for monitoring metal contamination in fish. Comparison of amino acid sequences between flounder MT and trout MT revealed that there is a conserved region at their N-terminals. Using oligonucleotides derived from this conserved region, reverse...

journal_title：Biochemical and biophysical research communications

authors： Chan KM

更新日期：1994-11-30 00:00:00

abstract：:Loaded under whole cell patch-clamp configuration, the caged Ca2+ molecule DM-nitrophen was used to increase [Ca2+]i rapidly and reversibly in isolated Deiters cells of the organ of Corti. Photolysis of DM-nitrophen increased [Ca2+]i from resting concentrations of 20-50 nM to values above microM, as measured with the ...

journal_title：Biochemical and biophysical research communications

authors： Dulon D,Blanchet C,Laffon E

更新日期：1994-06-30 00:00:00

abstract：:Monoclonal antibody BB1 was previously shown to recognize the CD80 protein as well as a putative B7.3 molecule, both ligands of the important T-cell receptors CD28 and CTLA-4. We report that BB1 coprecipitated from detergent lysates of human B- and pre-B-cell lines a protein kinase activity, as detected by solid phase...

journal_title：Biochemical and biophysical research communications

authors： Angelisová P,Cerný J,Horejsí V

更新日期：1996-11-12 00:00:00

abstract：:gamma-glutamyltranspeptidase (GGT) is a key enzyme implicated in the homeostasis of intracellular reduced glutathione (GSH) and hence in the regulation of the cellular redox state. Besides, the extracellular cleavage of GSH by GGT leads to reactive oxygen species (ROS) production, depending on the generation and enhan...

journal_title：Biochemical and biophysical research communications

authors： Accaoui MJ,Enoiu M,Mergny M,Masson C,Dominici S,Wellman M,Visvikis A

更新日期：2000-10-05 00:00:00

abstract：:To resolve a controversy in the literature concerning the affinity of Mg++ for ATP to be used in our noninvasive 31P NMR procedure for the determination of free Mg++ in living cells, we have reinvestigated the apparent dissociation constant of MgATP under physiologic ionic conditions and over the cellular range of ATP...

journal_title：Biochemical and biophysical research communications

authors： Gupta RK,Gupta P,Yushok WD,Rose ZB

更新日期：1983-11-30 00:00:00

abstract：:The proto-oncogene Akt is a potent inhibitor of apoptosis, and it is activated in many human cancers. A number of recent studies have highlighted the importance of the inositol 1,4,5-trisphosphate (IP3) receptor(IP3R) in mediating calcium (Ca2+) transfer from the endoplasmic reticulum (ER) to the mitochondriain severa...

journal_title：Biochemical and biophysical research communications

authors： Marchi S,Rimessi A,Giorgi C,Baldini C,Ferroni L,Rizzuto R,Pinton P

更新日期：2008-10-31 00:00:00

abstract：:Metabolic assay buffers often omit bicarbonate, which is susceptible to alkalinisation in an open environment. Here, we assessed the effect of including bicarbonate in respirometry experiments. By supplementing HEPES-buffered media with low concentrations of bicarbonate, we found increased respiration in adipocytes an...

journal_title：Biochemical and biophysical research communications

authors： Krycer JR,Fisher-Wellman KH,Fazakerley DJ,Muoio DM,James DE

更新日期：2017-08-05 00:00:00

abstract：:Enzymes belonging to the S9 family of prolyl oligopeptidases are of interest because of their pharmacological importance and have a non-catalytic β-propeller domain. In this study, we found that the oxidation of Met203, which lies on surface of the β-propeller domain, leads to change in the substrate specificity of er...

journal_title：Biochemical and biophysical research communications

authors： Tokai S,Bito T,Shimizu K,Arima J

更新日期：2017-05-27 00:00:00

abstract：:Human neuropeptide Y (NPY) analog ANA-NPY or [L17, Q19, A20, A23, L28, L31]NPY (13-36)-amide binds weakly to postjunctional receptors to raise blood pressure but binds tightly to prejunctional receptors to inhibit neurotransmitter release. ANA-NPY forms a well-conserved anti-parallel helical structure overlapping E23-...

journal_title：Biochemical and biophysical research communications

authors： Barden JA

更新日期：1995-10-04 00:00:00

abstract：:Human endothelial cell thrombin receptors were functionally expressed in Xenopus laevis oocytes by injection of RNA extracted from human umbilical vein endothelial cells. Oocytes injected with endothelial cell RNA responded to thrombin with a Ca2(+)-dependent depolarizing current whose size depended on the amount of R...

journal_title：Biochemical and biophysical research communications

authors： Pipili-Synetos E,Gershengorn MC,Jaffe EA

更新日期：1990-09-28 00:00:00

abstract：:Combined-modality treatment has improved the outcome in cases of various solid tumors, and radiosensitizers are used to enhance the radiotherapeutic efficiency. Rosiglitazone, a synthetic ligand of peroxisome proliferator-activated receptors gamma used in the treatment of type-2 diabetes, has been shown to reduce tumo...

journal_title：Biochemical and biophysical research communications

authors： Chiu SJ,Hsaio CH,Tseng HH,Su YH,Shih WL,Lee JW,Chuah JQ

更新日期：2010-04-09 00:00:00

abstract：:Action of protein kinases and phosphatases contributes to myocardial hypertrophy. PRL-3, a protein tyrosine phosphatase, was identified in a cDNA library from an explanted human heart obtained from a patient with idiopathic cardiomyopathy. PRL-3 is expressed in heart and skeletal muscle, exhibiting approximately 76% i...

journal_title：Biochemical and biophysical research communications

authors： Matter WF,Estridge T,Zhang C,Belagaje R,Stancato L,Dixon J,Johnson B,Bloem L,Pickard T,Donaghue M,Acton S,Jeyaseelan R,Kadambi V,Vlahos CJ

更新日期：2001-05-25 00:00:00