Measurement of the dissociation constant of MgATP at physiological nucleotide levels by a combination of 31P NMR and optical absorbance spectroscopy.

abstract：:The present study was performed to determine if interleukin-1 (IL-1) acts as a chemical messenger in the central nervous system (CNS) regulation of gastric secretion and ulcer formation, using male Wistar rats. The central injection of IL-1 dose-dependently inhibited gastric acid secretion in pylorus-ligated rats at 1...

journal_title：Biochemical and biophysical research communications

authors： Uehara A,Okumura T,Kitamori S,Takasugi Y,Namiki M

更新日期：1990-12-14 00:00:00

abstract：:The oxidative stress triggered by photodynamic therapy (PDT) involves generation of cytotoxic reactive oxygen species, including superoxide radical, accumulation of de novo-generated ceramide, and induction of apoptosis. Since PDT with the photosensitizer phthalocyanine Pc 4 induces mitochondrial damage and the supero...

journal_title：Biochemical and biophysical research communications

authors： Dolgachev V,Oberley LW,Huang TT,Kraniak JM,Tainsky MA,Hanada K,Separovic D

更新日期：2005-07-01 00:00:00

abstract：:The nuclear receptors for heme, REV-ERBα and REV-ERBβ, play important roles in the regulation of metabolism and inflammation. Recently it was demonstrated that reduced REV-ERBα expression in hematopoetic cells in LDL receptor null mice led to increased atherosclerosis. We sought to determine if synthetic REV-ERB agoni...

journal_title：Biochemical and biophysical research communications

authors： Sitaula S,Billon C,Kamenecka TM,Solt LA,Burris TP

更新日期：2015-05-08 00:00:00

abstract：:Recent findings identify the role of proliferation of pulmonary artery smooth muscle cells (PASMCs) in pulmonary vascular remodeling. Phosphoinositide 3 kinase (PI3K) and serine/threonine kinase (Akt) proteins are expressed in vascular smooth muscle cells. In addition, phosphatase and tensin homolog deleted on chromos...

journal_title：Biochemical and biophysical research communications

authors： Luo C,Yi B,Bai L,Xia Y,Wang G,Qian G,Feng H

更新日期：2010-07-02 00:00:00

abstract：:At an early stage of apoptosis, Jurkat cells transiently become susceptible to binding and phagocytosis by macrophages through the polylactosamine-type carbohydrate chains of CD43 [J. Biol. Chem. 279 (2004) 5967]. Susceptibility of apoptotic Jurkat cells to macrophage recognition was studied over an extended time rang...

journal_title：Biochemical and biophysical research communications

authors： Yamanaka M,Eda S,Beppu M

更新日期：2005-03-04 00:00:00

abstract：:Activated vascular endothelium inflammation under persistent hyperlipidemia is the initial step of atherogenesis. ATP-binding cassette G1 (ABCG1) is a crucial factor maintaining sterol and lipid homeostasis by transporting cholesterol efflux to high-density lipoprotein. In this study, we investigated the protective ef...

journal_title：Biochemical and biophysical research communications

authors： Xue S,Wang J,Zhang X,Shi Y,Li B,Bao Q,Pang W,Ai D,Zhu Y,He J

更新日期：2016-08-19 00:00:00

abstract：:To identify endoproteolytic activity that processes the enkephalin precursor, a novel approach was undertaken for the production of model substrate in the form of recombinant 35S-(Met)-preproenkephalin (35S-(Met)-PPE), generated by in vitro transcription and translation of the rat PPE cDNA. Endoproteolytic activity in...

journal_title：Biochemical and biophysical research communications

authors： Hook VY,Hegerle D,Affolter HU

更新日期：1990-03-16 00:00:00

abstract：:Clinicians successfully utilize high uptake of radiolabeled glucose via PET scanning to localize metastases in melanoma patients. To take advantage of this altered metabolome, 3-bromopyruvate (BrPA) was used to overcome the notorious resistance of melanoma to cell death. Using four melanoma cell lines, BrPA triggered ...

journal_title：Biochemical and biophysical research communications

authors： Qin JZ,Xin H,Nickoloff BJ

更新日期：2010-05-28 00:00:00

abstract：:A cDNA for tetrameric carbonyl reductase was cloned from a pig lung cDNA library. The cDNA had an open reading frame encoding a protein of 244 amino acid residues with a predicted monomer molecular weight of 25,985. The authenticity of the cDNA was confirmed by a perfect match of 80 amino acids determined from sequenc...

journal_title：Biochemical and biophysical research communications

authors： Nakanishi M,Deyashiki Y,Nakayama T,Sato K,Hara A

更新日期：1993-08-16 00:00:00

abstract：:Genomic DNA of the phytopathogenic Erwinia chrysanthemi PY35 was partially digested with Sau3AI, ligated into the BamHI site of pBluescript II SK+, and introduced into E. coli. One clone that was able to hydrolyse carboxymethylcellulose and polygalacturonic acid was selected. A 2.9 kb fragment containing the pelL1 gen...

journal_title：Biochemical and biophysical research communications

authors： Park SR,Kim MK,Kim JO,Bae DW,Cho SJ,Cho YU,Yun HD

更新日期：2000-02-16 00:00:00

abstract：:Conjugated linoleic acid (CLA), a group of minor fatty acids from ruminant origin, has long been recognized as a body fat lowering agent. Given the trans(t)10,cis(c)12-CLA well documented interference on lipolysis, we hypothesized for adipocytes altered permeation to glycerol when supplemented with this isomer. 3T3-L1...

journal_title：Biochemical and biophysical research communications

authors： Martins SV,Madeira A,Lopes PA,Pires VM,Alfaia CM,Prates JA,Moura T,Soveral G

更新日期：2015-03-06 00:00:00

abstract：:Release of soluble growth hormone binding protein (GHBP) corresponding to the extracellular domain of the GH receptor (GHR) occurs via distinct mechanisms depending on species. In human, proteolysis of full length GHR results in liberation of GHBP into the extracellular medium. A putative protease responsive for GHR c...

journal_title：Biochemical and biophysical research communications

authors： Conte F,Salles JP,Raynal P,Fernandez L,Molinas C,Tauber M,Bieth E

更新日期：2002-01-18 00:00:00

abstract：:The control of cellular adhesion to extracellular matrix proteins is poorly understood. In the present analyses, we set out to test the hypothesis that high galectin-3 concentration on the cell surface downregulates cellular adhesion to the extracellular matrix proteins. Various tumor cell lines were briefly incubated...

journal_title：Biochemical and biophysical research communications

authors： Ochieng J,Leite-Browning ML,Warfield P

更新日期：1998-05-29 00:00:00

abstract：:Labial grooves in maxillary incisors have been reported in several wild-type rodent species. Previous studies have reported age-dependent labial grooves occur in moderate prevalence in C57BL/6 mice; however, very little is known about the occurrence of such grooves. In the present study, we observed age-dependent groo...

journal_title：Biochemical and biophysical research communications

authors： Ota MS,Kondo K,Li Y,Iseki S,Yamashita A,Gibson CW,Kondo T

更新日期：2018-02-05 00:00:00

abstract：:Phosphofructokinase (PFK) from human polymorphonuclear leukocytes (PMN) was characterized by immunological titration with subunit specific antibodies, column chromatography on QAE-Sephadex and SDS-polyacrylamide gel electrophoresis. Two different isozymes, M-type and L-type, were found. The M(r) values of the M and L ...

journal_title：Biochemical and biophysical research communications

authors： Durante P,Raleigh X,Gómez ME,Campos G,Ryder E

更新日期：1995-11-22 00:00:00

abstract：:Proton release from HeLa cells is stimulated by external oxidants for the transplasmalemma electron transport enzymes. These oxidants, such as ferricyanide and diferric transferrin, also stimulate cell growth. We now present evidence that proton release associated with the reduction of ferricyanide and diferric transf...

journal_title：Biochemical and biophysical research communications

authors： Sun IL,Garcia-Cañero R,Liu W,Toole-Simms W,Crane FL,Morré DJ,Löw H

更新日期：1987-05-29 00:00:00

abstract：:STI-571 (imatinib, Gleevec, Glivec, CGP 57148) is an inhibitor of the Abl group of protein-tyrosine kinases. One of these enzymes, the Bcr-Abl oncoprotein, results from the fusion of the BCR and ABL genes that result from the reciprocal chromosomal translocation that forms the Philadelphia chromosome. The Philadelphia...

journal_title：Biochemical and biophysical research communications

authors： Roskoski R Jr

更新日期：2003-10-03 00:00:00

abstract：:Cyclin-dependent kinase-like 5 (CDKL5) is a Ser/Thr protein kinase primarily expressed in the central nervous system and is known to cause X-linked neurodevelopmental disorders such as Rett syndrome. However, the mechanisms regulating CDKL5 have not yet been fully clarified. Therefore, in this study, we investigated t...

journal_title：Biochemical and biophysical research communications

authors： Oi A,Katayama S,Hatano N,Sugiyama Y,Kameshita I,Sueyoshi N

更新日期：2017-01-08 00:00:00

abstract：:P-selectin is a cell adhesion molecule found in platelets and endothelial cells mediating binding of leukocytes. It is stored in secretory granules and expressed at the plasma membrane after cell activation. After rapid internalisation P-selectin recycles or is degraded. The 35 amino acid cytoplasmic domain of P-selec...

journal_title：Biochemical and biophysical research communications

authors： Florian V,Schlüter T,Bohnensack R

更新日期：2001-03-09 00:00:00

abstract：:Two alternatively spliced Caenorhabditis elegans G protein-coupled receptors, T19F4.1a and T19F4.1b, were cloned and functionally characterized. The T19F4.1b receptor protein is 30 amino acids longer than T19F4.1a, and the difference in amino acid constitution is exclusively conferred to the intracellular C-terminal r...

journal_title：Biochemical and biophysical research communications

authors： Mertens I,Meeusen T,Janssen T,Nachman R,Schoofs L

更新日期：2005-05-13 00:00:00

abstract：:Diffuse panbronchiolitis (DPB) is a chronic progressive disease of the respiratory bronchioles, and has been improved by low-dose, long-term erythromycin (EMC) treatment. The therapeutic benefits may be derived from its anti-inflammatory and immunomodulatory properties rather than antimicrobial effect. However, there ...

journal_title：Biochemical and biophysical research communications

authors： Park SJ,Lee YC,Rhee YK,Lee HB

更新日期：2004-11-05 00:00:00

abstract：:In virus-infected cells, viral RNA with non-self structural pattern is recognized by DExD/Hbox RNA helicase, RIG-I. Once RIG-I senses viral RNA, it triggers a signaling cascade, resulting in the activation of genes including type I interferon, which activates antiviral responses. Overexpression of N-terminal caspase a...

journal_title：Biochemical and biophysical research communications

authors： Kageyama M,Takahasi K,Narita R,Hirai R,Yoneyama M,Kato H,Fujita T

更新日期：2011-11-11 00:00:00

abstract：:Calcium is a key signaling molecule and ion involved in a variety of diverse processes in our central nervous system (CNS) which include gene expression, synaptic transmission and plasticity, neuronal excitability and cell maintenance. Proper control of calcium signaling is not only vital for neuronal physiology but a...

journal_title：Biochemical and biophysical research communications

authors： Mark MD,Schwitalla JC,Groemmke M,Herlitze S

更新日期：2017-02-19 00:00:00

abstract：:Vascular remodeling characterized by hyperproliferative neointima formation is an unfavorable repair process that is triggered by vascular damage. This process is characterized by an increased local inflammatory and proliferative response that critically involves the pro-inflammatory cytokine interleukin-1β (IL-1β). I...

journal_title：Biochemical and biophysical research communications

authors： Schlaweck S,Zimmer S,Struck R,Bartok E,Werner N,Bauernfeind F,Latz E,Nickenig G,Hornung V,Ghanem A

更新日期：2011-08-05 00:00:00

abstract：:The neuronal presynaptic membrane t-SNARE complex consists of the transmembrane protein syntaxin with the palmitoylated protein SNAP-25. In non-neuronal tissues, SNAP-23 replaces SNAP-25 in the t-SNARE complex, although the mechanism of membrane anchoring of SNAP-23 has not been determined. We now report that like SNA...

journal_title：Biochemical and biophysical research communications

authors： Vogel K,Roche PA

更新日期：1999-05-10 00:00:00

abstract：:PKM2 is an isoenzyme of the glycolytic enzyme pyruvate kinase that promotes aerobic glycolysis. Here, we describe an important role for PKM2 in regulating the survival of gastric cancer (GC) cells. We showed that PKM2 was overexpressed in gastric tumor tissues compared to normal tissues and its expression level was as...

journal_title：Biochemical and biophysical research communications

authors： Kwon OH,Kang TW,Kim JH,Kim M,Noh SM,Song KS,Yoo HS,Kim WH,Xie Z,Pocalyko D,Kim SY,Kim YS

更新日期：2012-06-22 00:00:00

abstract：:Prolactin, the Janus kinase 2 (JAK2) and the signal transducer and activator of transcription 5 (STAT5) are important for mammary gland development and have also been implicated in development and growth of breast tumors. In the present study we have investigated the role for JAK2 in proliferation, differentiation, an...

journal_title：Biochemical and biophysical research communications

authors： Olsen H,Hedengran Faulds MA,Saharinen P,Silvennoinen O,Haldosén LA

更新日期：2002-08-09 00:00:00

abstract：:The mitochondrial respiratory chain (MRC) supplies the majority of the energy requirements of most eucaryotic cells. A null mutation in the Caenorhabditis elegans nuo-1 gene encoding a subunit of complex I (NADH-ubiquinone oxidoreductase) is lethal, leading to a developmental arrest at the third larval stage. To ident...

journal_title：Biochemical and biophysical research communications

authors： Ndegwa S,Lemire BD

更新日期：2004-07-09 00:00:00

abstract：:Resistin, an adipocyte secreted cysteine rich hormone has been implicated as molecular link between obesity and type 2 diabetes in a murine model. Although, at the protein level mouse and human resistin show remarkable similarities with respect to conserved cysteine residues, the physiological role of human resistin i...

journal_title：Biochemical and biophysical research communications

authors： Raghu P,Ghosh S,Soundarya K,Haseeb A,Aruna B,Ehtesham NZ

更新日期：2004-01-16 00:00:00

abstract：:The concept of a glycolytic cancer cell was introduced by Warburg over 70 years ago. This perception has since become the rationale that drives a considerable proportion of basic research on cancer, and it influences the current strategies for the diagnosis, monitoring, and treatment of cancer. Here we review the data...

journal_title：Biochemical and biophysical research communications

authors： Zu XL,Guppy M

更新日期：2004-01-16 00:00:00