Proteoglycan gene expression in rat liver after partial hepatectomy.

Abstract:

:Liver regeneration is regulated by several factors. Among these extracellular matrix plays a crucial role in the restoration of normal structure. Proteoglycans are major components of extracellular matrix and they are able to bind growth factors implicated in liver growth. We studied syndecan, perlecan, fibroglycan, and decorin expression after partial hepatectomy in rats by Northern blot analysis. A strong early upregulation was observed at 30 min in decorin expression which was followed by the first syndecan and perlecan peaks at 2 and 4 hours after hepatectomy. At 24 hours, which is the peak of hepatocyte DNA synthesis, all these three proteoglycans had elevated steady state transcript level. Fibroglycan message decreased after partial hepatectomy and remained low during the experimental period. The different expression pattern of the proteoglycans suggests that these extracellular matrix components may selectively influence the regeneration process.

authors

Gallai M,Sebestyén A,Nagy P,Kovalszky I,Onody T,Thorgeirsson SS

doi

10.1006/bbrc.1996.1718

subject

Has Abstract

pub_date

1996-11-21 00:00:00

pages

690-4

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(96)91718-0

journal_volume

228

pub_type

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