Trichoplax, the simplest known animal, contains an estrogen-related receptor but no estrogen receptor: Implications for estrogen receptor evolution.

Abstract:

:Although, as their names imply, estrogen receptors [ERs] and estrogen-related receptors [ERRs] are related transcription factors, their evolutionary relationships to each other are not fully understood. To elucidate the origins and evolution of ERs and ERRs, we searched for their orthologs in the recently sequenced genome of Trichoplax, the simplest known animal, and in the genomes of three lophotrochozoans: Capitella, an annelid worm, Helobdella robusta, a leech, and Lottia gigantea, a snail. BLAST searches found an ERR in Trichoplax, but no ER. BLAST searches also found ERRs in all three lophotrochozoans and invertebrate-like ERs in Capitella and Lottia, but not in Helobdella. Unexpectedly we find that the Capitella ER sequence is closest to ERbeta, unlike the other invertebrate ER sequences, which are closest to ERalpha. Our database searches and phylogenetic analysis indicate that invertebrate ERs evolved in a lophotrochozoan and steroid-binding ERs evolved in a deuterostome.

authors

Baker ME

doi

10.1016/j.bbrc.2008.08.047

subject

Has Abstract

pub_date

2008-10-31 00:00:00

pages

623-7

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(08)01597-0

journal_volume

375

pub_type

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