Early plasma membrane depolarization by alpha interferon: biologic correlation with antiproliferative signal.

abstract：:In this study, we report the effect of endothelial progenitor cells (EPCs) on the biological behavior of osteoclast precursors in vitro by establishing an indirect co-culture system of mice EPCs and RAW 264.7 monocyte cells. Results show that the survival, migration, and differentiation of osteoclast precursors were g...

journal_title：Biochemical and biophysical research communications

authors： Pang H,Wu XH,Fu SL,Luo F,Zhang ZH,Hou TY,Li ZQ,Chang ZQ,Yu B,Xu JZ

更新日期：2013-01-11 00:00:00

abstract：:REG (Regenerating gene) Ialpha protein functions as a growth factor for gastrointestinal cancer cells, and its mRNA expression is strongly associated with a poor prognosis in gastrointestinal cancer patients. We here demonstrated that PPARgamma-agonist thiazolidinediones (TZDs) inhibited cell proliferation and REG Ial...

journal_title：Biochemical and biophysical research communications

authors： Yamauchi A,Takahashi I,Takasawa S,Nata K,Noguchi N,Ikeda T,Yoshikawa T,Shervani NJ,Suzuki I,Uruno A,Unno M,Okamoto H,Sugawara A

更新日期：2009-02-13 00:00:00

abstract：:Constitutive and PKC-regulated alpha-secretase pathways have been reported to produce the secreted form of alpha-secretase-derived APP (sAPPalpha). Here, we examined putative role of furin in the regulation of alpha-secretase activity in vitro and in vivo. Overexpression of the prodomain of furin and infection with a ...

journal_title：Biochemical and biophysical research communications

authors： Hwang EM,Kim SK,Sohn JH,Lee JY,Kim Y,Kim YS,Mook-Jung I

更新日期：2006-10-20 00:00:00

abstract：:Oxidative stress contributes to tissue injury and cell death during the development of various diseases. The present study aims at investigating whether oxidative stress triggered by the exposure to hydrogen peroxide (H(2)O(2)) can induce apoptosis of induced pluripotent stem cells (iPS cells) in a mechanism mediated ...

journal_title：Biochemical and biophysical research communications

authors： Li Y,Shelat H,Geng YJ

更新日期：2012-10-05 00:00:00

abstract：:An organic extract of Nitzschia alba cells possesses ionophoretic activity towards silicate, as it induces silicate transport across an organic phase or across synthetic lipid membranes. The activity is dependent upon Na+ and prefers silicon to germanium, a congener. The activity can be resolved into two apparently pu...

journal_title：Biochemical and biophysical research communications

authors： Bhattacharyya P,Volcani BE

更新日期：1983-07-18 00:00:00

abstract：:Colorectal cancer is one of the most common malignant tumors worldwide with rising incidence. MicroRNAs are small non-coding RNAs that implicate in multiple physiological or pathological processes. The aberrant expression of miRNA-215 (miR-215) has been illustrated in various types of cancers. However, the expression ...

journal_title：Biochemical and biophysical research communications

authors： Chen Z,Han S,Huang W,Wu J,Liu Y,Cai S,He Y,Wu S,Song W

更新日期：2016-10-21 00:00:00

abstract：:We show here a novel non-viral strategy to transduce human cells by using an EBV-based vector system. The EBV-based vectors, the plasmid vectors carrying EBV oriP (origin for plasmid replication) and EBNA (EBV nuclear antigen) 1 gene from EBV genome, were combined with 2 gene delivery systems, i.e., cationic liposome ...

journal_title：Biochemical and biophysical research communications

authors： Satoh E,Osawa M,Tomiyasu K,Hirai H,Shimazaki C,Oda Y,Nakagawa M,Kondo M,Kinoshita S,Mazda O,Imanishi J

更新日期：1997-09-29 00:00:00

abstract：:The cochlea in the mammalian inner ear is a sensitive and sharply organized sound-detecting structure. The proper specification of neurosensory-competent domain in the otic epithelium is required for the formation of mature neuronal and sensory domains. Genetic studies have provided many insights into inner ear develo...

journal_title：Biochemical and biophysical research communications

authors： Ma JH,Kim HP,Shin JO

更新日期：2019-05-14 00:00:00

abstract：:Enterolactone, a lignan that has been identified in biological samples from man and several mammals, shares with ascorbic acid and cardiac glycosides a gamma-butyrolactone. It displaces 3H-ouabain from its binding sites on cardiac digitalis receptor and inhibits, dose dependently, the Na+, K+-ATPase activity of human ...

journal_title：Biochemical and biophysical research communications

authors： Fagoo M,Braquet P,Robin JP,Esanu A,Godfraind T

更新日期：1986-02-13 00:00:00

abstract：:We identified 13 transcript isoforms of a trinucleotide-repeat-containing gene, cag-8, that is expressed almost exclusively in the mouse brain. The polypeptide deduced from the cDNA consists of 137 AAs, of which 74 are glutamines. The 130-kb gene is composed of 16 exons, from which at least 13 isoforms with variable U...

journal_title：Biochemical and biophysical research communications

authors： Ji JW,Yang HL,Kim SJ

更新日期：2006-08-11 00:00:00

abstract：:The Fragile X protein FMRP is an RNA binding protein whose targets are not well known; yet, these RNAs may play an integral role in the disease's etiology. Using a biotinylated-FMRP affinity resin, we isolated RNAs from the parietal cortex of a normal adult that bound FMRP. These RNAs were amplified by differential di...

journal_title：Biochemical and biophysical research communications

authors： Sung YJ,Conti J,Currie JR,Brown WT,Denman RB

更新日期：2000-09-07 00:00:00

abstract：:In this report we describe the initial characterization of murine, human, and Drosophila hesr-1 (for hairy and enhancer of split related-1) a novel evolutionary conserved family of hairy/enhancer of split homologs. Hesr-1 cDNAs display features typical of hairy and enhancer of split-type bHLH proteins including a N-te...

journal_title：Biochemical and biophysical research communications

authors： Kokubo H,Lun Y,Johnson RL

更新日期：1999-07-05 00:00:00

abstract：:Activins, TGF-beta superfamily members, have multiple functions in a variety of cells and tissues. Recently, additional activin beta subunit genes, betaC and betaE, have been identified. To explore the role of activin E, we created transgenic mice overexpressing human activin betaE subunit. There were pronounced diffe...

journal_title：Biochemical and biophysical research communications

authors： Hashimoto O,Ushiro Y,Sekiyama K,Yamaguchi O,Yoshioka K,Mutoh K,Hasegawa Y

更新日期：2006-03-10 00:00:00

abstract：:The 5'-flanking region of the human poly(ADP-ribose) polymerase gene was isolated and characterized. The nucleotide sequence of a part of the poly(ADP-ribose) polymerase gene completely matched that of the cDNA. The transcriptional initiation sites (cap sites) of this gene, located about 166-bp upstream from the trans...

journal_title：Biochemical and biophysical research communications

authors： Ogura T,Nyunoya H,Takahashi-Masutani M,Miwa M,Sugimura T,Esumi H

更新日期：1990-03-16 00:00:00

abstract：:Platelet aggregation plays a major role in thrombogenesis. This study was undertaken to examine the inhibition of platelet aggregation induced by adenosine diphosphate. It is known that cyclic AMP (adenosine monophosphate) and its dibutyryl derivative inhibit platelet aggregation. This study showed that prostagland...

journal_title：Biochemical and biophysical research communications

authors： Marquis NR,Vigdahl RL,Tavormina PA

更新日期：1969-09-10 00:00:00

abstract：:Cripto-1 (CR-1) is a transforming growth factor which has been associated with breast, colon, and pancreatic cancer. Overexpression of CR-1 in non-tumorigenic mouse mammary epithelial cells and fibroblasts results in an increase in anchorage-dependent and -independent growth in vitro. Reduction of CR-1 expression in h...

journal_title：Biochemical and biophysical research communications

authors： Kintner RL,Hosick HL

更新日期：1998-04-28 00:00:00

abstract：:Prolonged or repeated agonist activation of G-protein-coupled receptors (GPCRs) initiates their desensitization and internalization, rendering them unresponsive to agonist activation. We analyzed how gangliosides and chondroitin sulfate affect B2 bradykinin (BK) receptors (B2Rs). Gangliosides and chondroitin sulfate d...

journal_title：Biochemical and biophysical research communications

authors： Shimazaki A,Nakagawa T,Mitoma J,Higashi H

更新日期：2012-03-30 00:00:00

abstract：:Pro-aminopeptidase processing protease (PA protease) is an extracellular zinc metalloprotease produced by Aeromonas caviae T-64 and it is classified as M04.016 according to the MEROPS database. The precursor of PA protease consists of four regions; a signal peptide, an N-terminal propeptide, a C-terminal propeptide, a...

journal_title：Biochemical and biophysical research communications

authors： Tang B,Nirasawa S,Kitaoka M,Hayashi K

更新日期：2002-08-09 00:00:00

abstract：:Patient-derived xenografts (PDXs) are widely recognised as a more physiologically relevant preclinical model than standard cell lines, but are expensive and low throughput, have low engraftment rate and take a long time to develop. Our newly developed conditional reprogramming (CR) technology addresses many PDX drawba...

journal_title：Biochemical and biophysical research communications

authors： Mondal AM,Ma AH,Li G,Krawczyk E,Yuan R,Lu J,Schlegel R,Stamatakis L,Kowalczyk KJ,Philips GK,Pan CX,Liu X

更新日期：2019-09-10 00:00:00

abstract：:The functional importance of mitochondrial protein translation has been recently documented in the context of various cancers but not renal cell carcinoma (RCC). In lines with these efforts, our work demonstrates that mitochondrial translation inhibition by tigecycline or depletion of EF-Tu mitochondrial translation f...

journal_title：Biochemical and biophysical research communications

authors： Wang B,Ao J,Yu D,Rao T,Ruan Y,Yao X

更新日期：2017-08-26 00:00:00

abstract：:Our aim was to clarify the role of anti-phospholipid antibodies in the pathogenesis of monocyte tissue factor (TF) expression and thromboembolic complications (TE) in patients with SLE. We examined cell surface expression of TF on monocytes in 93 SLE patients. Monocyte TF expression was significantly higher in SLE pat...

journal_title：Biochemical and biophysical research communications

authors： Nojima J,Masuda Y,Iwatani Y,Suehisa E,Futsukaichi Y,Kuratsune H,Watanabe Y,Takano T,Hidaka Y,Kanakura Y

更新日期：2008-01-04 00:00:00

abstract：:The potential antiatherogenic actions of the angiotensin II receptor antagonist, losartan were investigated in apolipoprotein (apo) E deficient mice, an animal model with severe hypercholesterolemia and extensive atherosclerosis. In these animals accelerated atherosclerosis is associated with increased lipid peroxidat...

journal_title：Biochemical and biophysical research communications

authors： Keidar S,Attias J,Smith J,Breslow JL,Hayek T

更新日期：1997-07-30 00:00:00

abstract：:A novel mesenchymal protein, epimorphin, has been reported to play a key role in morphogenesis of fetal organs. The morphological and functional features of epimorphin in adult liver were entirely unknown. This study was performed to determine the distribution and function of this protein in the adult mouse liver. Epi...

journal_title：Biochemical and biophysical research communications

authors： Hirose M,Watanabe S,Oide H,Kitamura T,Miyazaki A,Sato N

更新日期：1996-08-05 00:00:00

abstract：:The application of Fast Atom Bombardment Mass Spectrometry to the measurement of small differences in molecular weight is discussed in relation to the spectra of bovine proinsulin and a genetic variant. ...

journal_title：Biochemical and biophysical research communications

authors： Cottrell JS,Frank BH

更新日期：1985-03-29 00:00:00

abstract：:Microinjection of inositol 1,3,4,5-tetrakisphosphate or inositol 1,4,5-trisphosphate induced distinct chloride membrane currents in defolliculated Xenopus laevis oocytes. To decide whether these Cl(-)-currents were due to the injected compounds or their metabolic products, [3H]Ins(1,3,4,5)P4 or [3H]Ins(1,4,5)P3 were i...

journal_title：Biochemical and biophysical research communications

authors： Guse AH,Gercken G,Boysen H,Schwarz JR,Meyerhof W

更新日期：1991-08-30 00:00:00

abstract：:The liver enriched transcription factors HNF-3 and HNF-4 are known to play major roles in development and differentiation of hepatocytes. STAT-3 and STAT-5 are signaling peptides activated by a variety of cytokines and growth factors including HGF and EGF. Their role in hepatocyte growth and differentiation is yet to ...

journal_title：Biochemical and biophysical research communications

authors： Runge D,Runge DM,Drenning SD,Bowen WC Jr,Grandis JR,Michalopoulos GK

更新日期：1998-09-29 00:00:00

abstract：:Cells from patients with acute myeloid leukaemia (AML) contain an abnormally high UDP-GlcNAc: Gal beta 1-3GalNAc-R (GlcNAc to GalNAc) beta 6-N-acetylglucosaminyltransferase (core 2 beta 6-Gn-T) activity. Upon UV irradiation at 350 nm, the substrate Gal beta 1-3GalNAc alpha-p-nitrophenyl acted as an effective inhibitor...

journal_title：Biochemical and biophysical research communications

authors： Toki D,Granovsky MA,Reck F,Kuhns W,Baker MA,Matta KL,Brockhausen I

更新日期：1994-01-28 00:00:00

abstract：:Linoleic acid, an omega-6 unsaturated fatty acid, stimulated growth of the MDA-MB-231 and MCF-7 human breast cancer cell lines in culture. Responses of the estrogen-independent MDA-MB-231 cells both in serum-free medium and with 1% fetal bovine serum added were positively correlated with linoleic acid concentration ov...

journal_title：Biochemical and biophysical research communications

authors： Rose DP,Connolly JM

更新日期：1989-10-16 00:00:00

abstract：:The eleven-nineteen lysine-rich leukemia protein (ELL) is a key regulator of RNA polymerase II mediated transcription. ELL facilitates RNA polymerase II transcription pause site entry and release by dynamically interacting with p300 and the positive transcription elongation factor b (P-TEFb). In this study, we investi...

journal_title：Biochemical and biophysical research communications

authors： Fufa TD,Byun JS,Wakano C,Fernandez AG,Pise-Masison CA,Gardner K

更新日期：2015-09-11 00:00:00

abstract：:Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that mediates rapid degradation of transcripts bearing premature translation termination codons (PTCs) and thereby limits the expression of unproductively processed mRNAs and the synthesis of C-terminally truncated peptides. Both its importance as a means to...

journal_title：Biochemical and biophysical research communications

authors： Boelz S,Neu-Yilik G,Gehring NH,Hentze MW,Kulozik AE

更新日期：2006-10-13 00:00:00