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Inositol tetrakisphosphates as second messengers induce Ca(++)-dependent chloride currents in Xenopus laevis oocytes.

Abstract：

:Microinjection of inositol 1,3,4,5-tetrakisphosphate or inositol 1,4,5-trisphosphate induced distinct chloride membrane currents in defolliculated Xenopus laevis oocytes. To decide whether these Cl(-)-currents were due to the injected compounds or their metabolic products, [3H]Ins(1,3,4,5)P4 or [3H]Ins(1,4,5)P3 were injected into oocytes and their metabolites were analyzed by HPLC. Our results indicate that Ins(1,3,4,5)P4 itself or its metabolite Ins(1,3,4,6)P4 is able to induce Cl(-)-membrane currents, most likely by increasing the cytosolic Ca(++)-concentration.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Guse AH,Gercken G,Boysen H,Schwarz JR,Meyerhof W

doi

10.1016/0006-291x(91)91420-h

subject

Has Abstract

pub_date

1991-08-30 00:00:00

pages

641-7

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(91)91420-H

journal_volume

179

pub_type

杂志文章

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